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Lesion Symptom Mapping of Manipulable Object Naming in Nonfluent Aphasia: Can a Brain be both Embodied and Disembodied?

Identifieur interne : 001998 ( Pmc/Corpus ); précédent : 001997; suivant : 001999

Lesion Symptom Mapping of Manipulable Object Naming in Nonfluent Aphasia: Can a Brain be both Embodied and Disembodied?

Auteurs : Jamie Reilly ; Stacy Harnish ; Amanda Garcia ; Jinyi Hung ; Amy D. Rodriguez ; Bruce Crosson

Source :

RBID : PMC:4091963

Abstract

Embodied cognition offers an approach to word meaning firmly grounded in action and perception. A strong prediction of embodied cognition is that sensorimotor simulation is a necessary component of lexical-semantic representation. One semantic distinction where motor imagery is likely to play a key role involves the representation of manufactured artifacts. Many questions remain with respect to the scope of embodied cognition. One dominant unresolved issue is the extent to which motor enactment is necessary for representing and generating words with high motor salience. We investigated lesion correlates of manipulable relative to non-manipulable name generation (e.g., name a school supply; name a mountain range) in patients with nonfluent aphasia (N=14). Lesion volumes within motor (BA4) and premotor (BA6) cortices were not predictive of category discrepancies. Lesion symptom mapping linked impairment for manipulable objects to polymodal convergence zones and to projections of the left, primary visual cortex specialized for motion perception (MT/V5+). Lesions to motor and premotor cortex were not predictive of manipulability impairment. This lesion correlation is incompatible with an embodied perspective premised on necessity of motor cortex for the enactment and subsequent production of motor-related words. These findings instead support a graded or ‘soft’ approach to embodied cognition premised on an ancillary role of modality-specific cortical regions in enriching modality-neutral representations. We discuss a dynamic, hybrid approach to the neurobiology of semantic memory integrating both embodied and disembodied components.


Url:
DOI: 10.1080/02643294.2014.914022
PubMed: 24839997
PubMed Central: 4091963

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