Late onset muscle plasticity in the whisker pad of enucleated rats
Identifieur interne : 001532 ( Pmc/Corpus ); précédent : 001531; suivant : 001533Late onset muscle plasticity in the whisker pad of enucleated rats
Auteurs : Brenda Toscano-Márquez ; Eduardo Martínez-Martínez ; Elías Manjarrez ; Lourdes Martínez ; Julieta Mendoza-Torreblanca ; Gabriel Gutiérrez-OspinaSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2008.
Abstract
Blindness leads to a major reorganization of neural pathways associated with touch. Because incoming somatosensory information influences motor output, it is plausible that motor plasticity occurs in the blind. In this work, we evaluated this issue at the peripheral level in enucleated rats. Whisker muscles in enucleated rats 160 days of age or older showed increased cytochrome oxidase activity, capillary density, motor plate size, and amplitude of evoked field potentials as compared with their control counterparts. Such differences were not observed at ages 10 and 60 days, the capillary density was the exception being greater in the enucleated rat at the latter age. Interestingly, there was a trend to increased neurotrophin-3 concentrations in the whisker pads of enucleated rats throughout postnatal development. Our results show that neonatal enucleation leads to late onset plasticity of the whisker's motor system.
Url:
DOI: 10.1073/pnas.0808431105
PubMed: 18838691
PubMed Central: 2572979
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