BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
Identifieur interne : 001332 ( Pmc/Corpus ); précédent : 001331; suivant : 001333BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
Auteurs : Stephanie A. Mchughen ; Paul F. Rodriguez ; Jeffrey A. Kleim ; Erin D. Kleim ; Laura Marchal Crespo ; Vincent Procaccio ; Steven C. CramerSource :
- Cerebral Cortex (New York, NY) [ 1047-3211 ] ; 2009.
Abstract
Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val66met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (
Url:
DOI: 10.1093/cercor/bhp189
PubMed: 19745020
PubMed Central: 2852510
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