Enzyme Closure and Nucleotide Binding Structurally Lock Guanylate Kinase
Identifieur interne : 001306 ( Pmc/Corpus ); précédent : 001305; suivant : 001307Enzyme Closure and Nucleotide Binding Structurally Lock Guanylate Kinase
Auteurs : Olivier Delalande ; Sophie Sacquin-Mora ; Marc BaadenSource :
- Biophysical Journal [ 0006-3495 ] ; 2011.
Abstract
We investigate the conformational dynamics and mechanical properties of guanylate kinase (GK) using a multiscale approach combining high-resolution atomistic molecular dynamics and low-resolution Brownian dynamics simulations. The GK enzyme is subject to large conformational changes, leading from an open to a closed form, which are further influenced by the presence of nucleotides. As suggested by recent work on simple coarse-grained models of
Url:
DOI: 10.1016/j.bpj.2011.07.048
PubMed: 21943425
PubMed Central: 3177050
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