Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI
Identifieur interne : 000252 ( Pmc/Corpus ); précédent : 000251; suivant : 000253Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI
Auteurs : Victoria Kegel ; Elisa Pfeiffer ; Britta Burkhardt ; Jia L. Liu ; Katrin Zeilinger ; Andreas K. Nüssler ; Daniel Seehofer ; Georg DammSource :
- Mediators of Inflammation [ 0962-9351 ] ; 2015.
Abstract
Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI. Aim of the present study was to establish a human
Url:
DOI: 10.1155/2015/640631
PubMed: 26491234
PubMed Central: 4600928
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