Light-adjustable lens.
Identifieur interne : 002629 ( Pmc/Checkpoint ); précédent : 002628; suivant : 002630Light-adjustable lens.
Auteurs : Daniel M. SchwartzSource :
- Transactions of the American Ophthalmological Society [ 0065-9533 ] ; 2003.
Abstract
PURPOSE: First, to determine whether a silicone light-adjustable intraocular lens (IOL) can be fabricated and adjusted precisely with a light delivery device (LDD). Second, to determine the biocompatibility of an adjustable IOL and whether the lens can be adjusted precisely in vivo. METHODS: After fabrication of a light-adjustable silicone formulation, IOLs were made and tested in vitro for cytotoxicity, leaching, precision of adjustment, optical quality after adjustment, and mechanical properties. Light-adjustable IOLs were then tested in vivo for biocompatibility and precision of adjustment in a rabbit model. In collaboration with Zeiss-Meditec, a digital LDD was developed and tested to correct for higher-order aberrations in light-adjustable IOLs. RESULTS: The results establish that a biocompatible silicone IOL can be fabricated and adjusted using safe levels of light. There was no evidence of cytotoxicity or leaching. Testing of mechanical properties revealed no significant differences from commercial controls. Implantation of light-adjustable lenses in rabbits demonstrated- excellent biocompatibility after 6 months, comparable to a commercially available IOL. In vivo spherical (hyperopic and myopic) adjustment in rabbits was achieved using an analog light delivery system. The digital light delivery system was tested and achieved correction of higher-order aberrations. CONCLUSION: A silicone light-adjustable IOL and LDD have been developed to enable postoperative, noninvasive adjustment of lens power. The ability to correct higher-order aberrations in these materials has broad potential applicability for optimization of vision in patients undergoing cataract and refractive surgery.
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PubMed: 14971588
PubMed Central: 1358999
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Light-adjustable lens.</title><author><name sortKey="Schwartz, Daniel M" sort="Schwartz, Daniel M" uniqKey="Schwartz D" first="Daniel M" last="Schwartz">Daniel M. Schwartz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">14971588</idno><idno type="pmc">1358999</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1358999</idno><idno type="RBID">PMC:1358999</idno><date when="2003">2003</date><idno type="wicri:Area/Pmc/Corpus">000B02</idno><idno type="wicri:Area/Pmc/Curation">000B02</idno><idno type="wicri:Area/Pmc/Checkpoint">002629</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Light-adjustable lens.</title><author><name sortKey="Schwartz, Daniel M" sort="Schwartz, Daniel M" uniqKey="Schwartz D" first="Daniel M" last="Schwartz">Daniel M. Schwartz</name></author></analytic><series><title level="j">Transactions of the American Ophthalmological Society</title><idno type="ISSN">0065-9533</idno><idno type="eISSN">1545-6110</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>PURPOSE: First, to determine whether a silicone light-adjustable intraocular lens (IOL) can be fabricated and adjusted precisely with a light delivery device (LDD). Second, to determine the biocompatibility of an adjustable IOL and whether the lens can be adjusted precisely in vivo. METHODS: After fabrication of a light-adjustable silicone formulation, IOLs were made and tested in vitro for cytotoxicity, leaching, precision of adjustment, optical quality after adjustment, and mechanical properties. Light-adjustable IOLs were then tested in vivo for biocompatibility and precision of adjustment in a rabbit model. In collaboration with Zeiss-Meditec, a digital LDD was developed and tested to correct for higher-order aberrations in light-adjustable IOLs. RESULTS: The results establish that a biocompatible silicone IOL can be fabricated and adjusted using safe levels of light. There was no evidence of cytotoxicity or leaching. Testing of mechanical properties revealed no significant differences from commercial controls. Implantation of light-adjustable lenses in rabbits demonstrated- excellent biocompatibility after 6 months, comparable to a commercially available IOL. In vivo spherical (hyperopic and myopic) adjustment in rabbits was achieved using an analog light delivery system. The digital light delivery system was tested and achieved correction of higher-order aberrations. CONCLUSION: A silicone light-adjustable IOL and LDD have been developed to enable postoperative, noninvasive adjustment of lens power. The ability to correct higher-order aberrations in these materials has broad potential applicability for optimization of vision in patients undergoing cataract and refractive surgery.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Trans Am Ophthalmol Soc</journal-id><journal-title>Transactions of the American Ophthalmological Society</journal-title><issn pub-type="ppub">0065-9533</issn><issn pub-type="epub">1545-6110</issn></journal-meta><article-meta><article-id pub-id-type="pmid">14971588</article-id><article-id pub-id-type="pmc">1358999</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Light-adjustable lens.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schwartz</surname><given-names>Daniel M</given-names></name></contrib></contrib-group><aff>University of California, San Francisco, USA.</aff><pub-date pub-type="ppub"><year>2003</year></pub-date><volume>101</volume><fpage>417</fpage><lpage>436</lpage><abstract><p>PURPOSE: First, to determine whether a silicone light-adjustable intraocular lens (IOL) can be fabricated and adjusted precisely with a light delivery device (LDD). Second, to determine the biocompatibility of an adjustable IOL and whether the lens can be adjusted precisely in vivo. METHODS: After fabrication of a light-adjustable silicone formulation, IOLs were made and tested in vitro for cytotoxicity, leaching, precision of adjustment, optical quality after adjustment, and mechanical properties. Light-adjustable IOLs were then tested in vivo for biocompatibility and precision of adjustment in a rabbit model. In collaboration with Zeiss-Meditec, a digital LDD was developed and tested to correct for higher-order aberrations in light-adjustable IOLs. RESULTS: The results establish that a biocompatible silicone IOL can be fabricated and adjusted using safe levels of light. There was no evidence of cytotoxicity or leaching. Testing of mechanical properties revealed no significant differences from commercial controls. Implantation of light-adjustable lenses in rabbits demonstrated- excellent biocompatibility after 6 months, comparable to a commercially available IOL. In vivo spherical (hyperopic and myopic) adjustment in rabbits was achieved using an analog light delivery system. The digital light delivery system was tested and achieved correction of higher-order aberrations. CONCLUSION: A silicone light-adjustable IOL and LDD have been developed to enable postoperative, noninvasive adjustment of lens power. The ability to correct higher-order aberrations in these materials has broad potential applicability for optimization of vision in patients undergoing cataract and refractive surgery.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Schwartz, Daniel M" sort="Schwartz, Daniel M" uniqKey="Schwartz D" first="Daniel M" last="Schwartz">Daniel M. Schwartz</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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