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Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model

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Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model

Auteurs : Liliana Werner ; Salwa Abdel-Aziz ; Carolee Cutler Peck ; Bryan Monson ; Ladan Espandar ; Brian Zaugg ; Jack Stringham ; Chris Wilcox ; Nick Mamalis

Source :

Journal of cataract and refractive surgery [ 0886-3350 ] ; 2011.

RBID : PMC:3033600

Abstract

PURPOSE

To assess the long-term biocompatibility and photochromic stability of a new photochromic hydrophobic acrylic intraocular lens (IOL) under extended ultraviolet (UV) light exposure.

SETTING

John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

DESIGN

Experimental study.

METHODS

A Matrix Aurium photochromic IOL was implanted in right eyes and a Matrix Acrylic IOL without photochromic properties (n = 6) or a single-piece AcrySof Natural SN60AT (N = 5) IOL in left eyes of 11 New Zealand rabbits. The rabbits were exposed to a UV light source of 5 mW/cm² for 3 hours during every 8-hour period, equivalent to 9 hours a day, and followed for up to 12 months. The photochromic changes were evaluated during slitlamp examination by shining a penlight UV source in the right eye. After the rabbits were humanely killed and the eyes enucleated, study and control IOLs were explanted and evaluated in vitro on UV exposure and studied histopathologically.

RESULTS

The photochromic IOL was as biocompatible as the control IOLs after 12 months under conditions simulating at least 20 years of UV exposure. In vitro evaluation confirmed the retained optical properties, with photochromic changes observed within 7 seconds of UV exposure. The rabbit eyes had clinical and histopathological changes expected in this model with a 12-month follow-up.

CONCLUSIONS

The new photochromic IOL turned yellow only on exposure to UV light. The photochromic changes were reversible, reproducible, and stable over time. The IOL was biocompatible with up to 12 months of accelerated UV exposure simulation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033600

DOI: 10.1016/j.jcrs.2010.08.052
PubMed: 21241924
PubMed Central: 3033600

Affiliations:

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PMC:3033600

Le document en format XML

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<author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
</author>
<author><name sortKey="Abdel Aziz, Salwa" sort="Abdel Aziz, Salwa" uniqKey="Abdel Aziz S" first="Salwa" last="Abdel-Aziz">Salwa Abdel-Aziz</name>
</author>
<author><name sortKey="Peck, Carolee Cutler" sort="Peck, Carolee Cutler" uniqKey="Peck C" first="Carolee Cutler" last="Peck">Carolee Cutler Peck</name>
</author>
<author><name sortKey="Monson, Bryan" sort="Monson, Bryan" uniqKey="Monson B" first="Bryan" last="Monson">Bryan Monson</name>
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<author><name sortKey="Espandar, Ladan" sort="Espandar, Ladan" uniqKey="Espandar L" first="Ladan" last="Espandar">Ladan Espandar</name>
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<author><name sortKey="Zaugg, Brian" sort="Zaugg, Brian" uniqKey="Zaugg B" first="Brian" last="Zaugg">Brian Zaugg</name>
</author>
<author><name sortKey="Stringham, Jack" sort="Stringham, Jack" uniqKey="Stringham J" first="Jack" last="Stringham">Jack Stringham</name>
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<author><name sortKey="Wilcox, Chris" sort="Wilcox, Chris" uniqKey="Wilcox C" first="Chris" last="Wilcox">Chris Wilcox</name>
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<author><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model</title>
<author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
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<author><name sortKey="Abdel Aziz, Salwa" sort="Abdel Aziz, Salwa" uniqKey="Abdel Aziz S" first="Salwa" last="Abdel-Aziz">Salwa Abdel-Aziz</name>
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<author><name sortKey="Peck, Carolee Cutler" sort="Peck, Carolee Cutler" uniqKey="Peck C" first="Carolee Cutler" last="Peck">Carolee Cutler Peck</name>
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<author><name sortKey="Monson, Bryan" sort="Monson, Bryan" uniqKey="Monson B" first="Bryan" last="Monson">Bryan Monson</name>
</author>
<author><name sortKey="Espandar, Ladan" sort="Espandar, Ladan" uniqKey="Espandar L" first="Ladan" last="Espandar">Ladan Espandar</name>
</author>
<author><name sortKey="Zaugg, Brian" sort="Zaugg, Brian" uniqKey="Zaugg B" first="Brian" last="Zaugg">Brian Zaugg</name>
</author>
<author><name sortKey="Stringham, Jack" sort="Stringham, Jack" uniqKey="Stringham J" first="Jack" last="Stringham">Jack Stringham</name>
</author>
<author><name sortKey="Wilcox, Chris" sort="Wilcox, Chris" uniqKey="Wilcox C" first="Chris" last="Wilcox">Chris Wilcox</name>
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<author><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name>
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<series><title level="j">Journal of cataract and refractive surgery</title>
<idno type="ISSN">0886-3350</idno>
<idno type="eISSN">1873-4502</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>PURPOSE</title>
<p id="P2">To assess the long-term biocompatibility and photochromic stability of a new photochromic hydrophobic acrylic intraocular lens (IOL) under extended ultraviolet (UV) light exposure.</p>
</sec>
<sec id="S2"><title>SETTING</title>
<p id="P3">John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.</p>
</sec>
<sec id="S3"><title>DESIGN</title>
<p id="P4">Experimental study.</p>
</sec>
<sec sec-type="methods" id="S4"><title>METHODS</title>
<p id="P5">A Matrix Aurium photochromic IOL was implanted in right eyes and a Matrix Acrylic IOL without photochromic properties (n = 6) or a single-piece AcrySof Natural SN60AT (N = 5) IOL in left eyes of 11 New Zealand rabbits. The rabbits were exposed to a UV light source of 5 mW/cm<sup>2</sup>
 for 3 hours during every 8-hour period, equivalent to 9 hours a day, and followed for up to 12 months. The photochromic changes were evaluated during slitlamp examination by shining a penlight UV source in the right eye. After the rabbits were humanely killed and the eyes enucleated, study and control IOLs were explanted and evaluated in vitro on UV exposure and studied histopathologically.</p>
</sec>
<sec id="S5"><title>RESULTS</title>
<p id="P6">The photochromic IOL was as biocompatible as the control IOLs after 12 months under conditions simulating at least 20 years of UV exposure. In vitro evaluation confirmed the retained optical properties, with photochromic changes observed within 7 seconds of UV exposure. The rabbit eyes had clinical and histopathological changes expected in this model with a 12-month follow-up.</p>
</sec>
<sec id="S6"><title>CONCLUSIONS</title>
<p id="P7">The new photochromic IOL turned yellow only on exposure to UV light. The photochromic changes were reversible, reproducible, and stable over time. The IOL was biocompatible with up to 12 months of accelerated UV exposure simulation.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8604171</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5175</journal-id>
<journal-id journal-id-type="nlm-ta">J Cataract Refract Surg</journal-id>
<journal-title>Journal of cataract and refractive surgery</journal-title>
<issn pub-type="ppub">0886-3350</issn>
<issn pub-type="epub">1873-4502</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21241924</article-id>
<article-id pub-id-type="pmc">3033600</article-id>
<article-id pub-id-type="doi">10.1016/j.jcrs.2010.08.052</article-id>
<article-id pub-id-type="manuscript">NIHMS261034</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Werner</surname>
<given-names>Liliana</given-names>
</name>
<degrees>MD, PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Abdel-Aziz</surname>
<given-names>Salwa</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Peck</surname>
<given-names>Carolee Cutler</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Monson</surname>
<given-names>Bryan</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Espandar</surname>
<given-names>Ladan</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Zaugg</surname>
<given-names>Brian</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Stringham</surname>
<given-names>Jack</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wilcox</surname>
<given-names>Chris</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mamalis</surname>
<given-names>Nick</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff id="A1">John A. Moran Eye Center (Werner, Abdel-Aziz, Cutler Peck, Monson, Espandar, Zaugg, Stringham, Mamalis), University of Utah, Salt Lake City, Utah, and Medennium, Inc. (Wilcox), Irvine, California, USA</aff>
</contrib-group>
<author-notes><fn id="FN1"><p id="P1">Mr. Wilcox is an employee of and Dr. Mamalis is a member of the scientific advisory board of Medennium, Inc.</p>
</fn>
<corresp id="CR1">Corresponding author: Liliana Werner, MD, PhD, John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, Utah 84132, USA. <email>liliana.werner@hsc.utah.edu</email>
.</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>14</day>
<month>1</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>2</month>
<year>2012</year>
</pub-date>
<volume>37</volume>
<issue>2</issue>
<fpage>378</fpage>
<lpage>385</lpage>
<permissions><copyright-statement>© 2010 American Society of Cataract and Refractive Surgery and European Society of Cataract and Refractive Surgeons. Published by Elsevier Inc. All rights reserved</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><sec id="S1"><title>PURPOSE</title>
<p id="P2">To assess the long-term biocompatibility and photochromic stability of a new photochromic hydrophobic acrylic intraocular lens (IOL) under extended ultraviolet (UV) light exposure.</p>
</sec>
<sec id="S2"><title>SETTING</title>
<p id="P3">John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.</p>
</sec>
<sec id="S3"><title>DESIGN</title>
<p id="P4">Experimental study.</p>
</sec>
<sec sec-type="methods" id="S4"><title>METHODS</title>
<p id="P5">A Matrix Aurium photochromic IOL was implanted in right eyes and a Matrix Acrylic IOL without photochromic properties (n = 6) or a single-piece AcrySof Natural SN60AT (N = 5) IOL in left eyes of 11 New Zealand rabbits. The rabbits were exposed to a UV light source of 5 mW/cm<sup>2</sup>
 for 3 hours during every 8-hour period, equivalent to 9 hours a day, and followed for up to 12 months. The photochromic changes were evaluated during slitlamp examination by shining a penlight UV source in the right eye. After the rabbits were humanely killed and the eyes enucleated, study and control IOLs were explanted and evaluated in vitro on UV exposure and studied histopathologically.</p>
</sec>
<sec id="S5"><title>RESULTS</title>
<p id="P6">The photochromic IOL was as biocompatible as the control IOLs after 12 months under conditions simulating at least 20 years of UV exposure. In vitro evaluation confirmed the retained optical properties, with photochromic changes observed within 7 seconds of UV exposure. The rabbit eyes had clinical and histopathological changes expected in this model with a 12-month follow-up.</p>
</sec>
<sec id="S6"><title>CONCLUSIONS</title>
<p id="P7">The new photochromic IOL turned yellow only on exposure to UV light. The photochromic changes were reversible, reproducible, and stable over time. The IOL was biocompatible with up to 12 months of accelerated UV exposure simulation.</p>
</sec>
</abstract>
<contract-num rid="EY1">R43 EY017796-01A1
				||EY</contract-num>
<contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Abdel Aziz, Salwa" sort="Abdel Aziz, Salwa" uniqKey="Abdel Aziz S" first="Salwa" last="Abdel-Aziz">Salwa Abdel-Aziz</name>
<name sortKey="Espandar, Ladan" sort="Espandar, Ladan" uniqKey="Espandar L" first="Ladan" last="Espandar">Ladan Espandar</name>
<name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name>
<name sortKey="Monson, Bryan" sort="Monson, Bryan" uniqKey="Monson B" first="Bryan" last="Monson">Bryan Monson</name>
<name sortKey="Peck, Carolee Cutler" sort="Peck, Carolee Cutler" uniqKey="Peck C" first="Carolee Cutler" last="Peck">Carolee Cutler Peck</name>
<name sortKey="Stringham, Jack" sort="Stringham, Jack" uniqKey="Stringham J" first="Jack" last="Stringham">Jack Stringham</name>
<name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
<name sortKey="Wilcox, Chris" sort="Wilcox, Chris" uniqKey="Wilcox C" first="Chris" last="Wilcox">Chris Wilcox</name>
<name sortKey="Zaugg, Brian" sort="Zaugg, Brian" uniqKey="Zaugg B" first="Brian" last="Zaugg">Brian Zaugg</name>
</noCountry>
</tree>
</affiliations>
</record>

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Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model

Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model

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