Left Parietal regions are critical for adaptive visuomotor control
Identifieur interne : 001A97 ( Pmc/Checkpoint ); précédent : 001A96; suivant : 001A98Left Parietal regions are critical for adaptive visuomotor control
Auteurs : Pratik K. Mutha [États-Unis] ; Robert L. Sainburg [États-Unis] ; Kathleen Y. Haaland [États-Unis]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 0270-6474 ] ; 2011.
Abstract
The question addressed in this study is whether parietal brain circuits involved in adaptation to novel visuomotor conditions, are lateralized. This information is critical for characterizing the neural mechanisms mediating adaptive behavior in humans, as well as for assessing the effects of unilateral brain damage on function. Moreover, previous research has been controversial in this regard. We compared visuomotor adaptation in 10 patients with focal, unilateral, left or right parietal lesions and healthy control participants. All subjects reached to each of eight targets over three experimental sessions: a baseline session, where the visually-displayed and actual hand motion were matched; an adaptation session where the visual feedback deviated from the actual movement direction by 30-degrees and an after-effect session where visual feedback was again matched to hand motion. Adaptation was primarily quantified as a change in initial movement direction throughout the adaptation session and the presence of after-effects when the rotation was removed. Patients with right parietal damage demonstrated normal adaptation and large after-effects, which was comparable to the performance of healthy controls. In contrast, patients with left parietal damage showed a clear deficit in adaptation and showed no after-effects. Thus, our results show that left, but not right parietal regions are critical for visuomotor adaptation. These findings are discussed in the context that left parietal regions are critical for the modification of stored representations of the relationship between movement commands and limb and environmental state, as is thought to occur during visuomotor adaptation.
Url:
DOI: 10.1523/JNEUROSCI.6432-10.2011
PubMed: 21562259
PubMed Central: 3107546
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3107546Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Left Parietal regions are critical for adaptive visuomotor control</title>
<author><name sortKey="Mutha, Pratik K" sort="Mutha, Pratik K" uniqKey="Mutha P" first="Pratik K." last="Mutha">Pratik K. Mutha</name>
<affiliation wicri:level="2"><nlm:aff id="A1">NM VA Healthcare System, Albuquerque, NM 87108</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>NM VA Healthcare System, Albuquerque</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Kinesiology, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Kinesiology, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sainburg, Robert L" sort="Sainburg, Robert L" uniqKey="Sainburg R" first="Robert L." last="Sainburg">Robert L. Sainburg</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Kinesiology, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Kinesiology, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Program in Neuroscience, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Program in Neuroscience, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haaland, Kathleen Y" sort="Haaland, Kathleen Y" uniqKey="Haaland K" first="Kathleen Y." last="Haaland">Kathleen Y. Haaland</name>
<affiliation wicri:level="2"><nlm:aff id="A1">NM VA Healthcare System, Albuquerque, NM 87108</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>NM VA Healthcare System, Albuquerque</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>Department of Psychiatry, University of New Mexico, Albuquerque</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Neurology, University of New Mexico, Albuquerque, NM 87131</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of New Mexico, Albuquerque</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21562259</idno>
<idno type="pmc">3107546</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107546</idno>
<idno type="RBID">PMC:3107546</idno>
<idno type="doi">10.1523/JNEUROSCI.6432-10.2011</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001184</idno>
<idno type="wicri:Area/Pmc/Curation">001184</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001A97</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Left Parietal regions are critical for adaptive visuomotor control</title>
<author><name sortKey="Mutha, Pratik K" sort="Mutha, Pratik K" uniqKey="Mutha P" first="Pratik K." last="Mutha">Pratik K. Mutha</name>
<affiliation wicri:level="2"><nlm:aff id="A1">NM VA Healthcare System, Albuquerque, NM 87108</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>NM VA Healthcare System, Albuquerque</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Kinesiology, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Kinesiology, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sainburg, Robert L" sort="Sainburg, Robert L" uniqKey="Sainburg R" first="Robert L." last="Sainburg">Robert L. Sainburg</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Kinesiology, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Kinesiology, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Program in Neuroscience, Pennsylvania State University, University Park, PA 16802</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Program in Neuroscience, Pennsylvania State University, University Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haaland, Kathleen Y" sort="Haaland, Kathleen Y" uniqKey="Haaland K" first="Kathleen Y." last="Haaland">Kathleen Y. Haaland</name>
<affiliation wicri:level="2"><nlm:aff id="A1">NM VA Healthcare System, Albuquerque, NM 87108</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>NM VA Healthcare System, Albuquerque</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>Department of Psychiatry, University of New Mexico, Albuquerque</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Neurology, University of New Mexico, Albuquerque, NM 87131</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of New Mexico, Albuquerque</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title>
<idno type="ISSN">0270-6474</idno>
<idno type="eISSN">1529-2401</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The question addressed in this study is whether parietal brain circuits involved in adaptation to novel visuomotor conditions, are lateralized. This information is critical for characterizing the neural mechanisms mediating adaptive behavior in humans, as well as for assessing the effects of unilateral brain damage on function. Moreover, previous research has been controversial in this regard. We compared visuomotor adaptation in 10 patients with focal, unilateral, left or right parietal lesions and healthy control participants. All subjects reached to each of eight targets over three experimental sessions: a baseline session, where the visually-displayed and actual hand motion were matched; an adaptation session where the visual feedback deviated from the actual movement direction by 30-degrees and an after-effect session where visual feedback was again matched to hand motion. Adaptation was primarily quantified as a change in initial movement direction throughout the adaptation session and the presence of after-effects when the rotation was removed. Patients with right parietal damage demonstrated normal adaptation and large after-effects, which was comparable to the performance of healthy controls. In contrast, patients with left parietal damage showed a clear deficit in adaptation and showed no after-effects. Thus, our results show that left, but not right parietal regions are critical for visuomotor adaptation. These findings are discussed in the context that left parietal regions are critical for the modification of stored representations of the relationship between movement commands and limb and environmental state, as is thought to occur during visuomotor adaptation.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8102140</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5035</journal-id>
<journal-id journal-id-type="nlm-ta">J Neurosci</journal-id>
<journal-title-group><journal-title>The Journal of neuroscience : the official journal of the Society for Neuroscience</journal-title>
</journal-title-group>
<issn pub-type="ppub">0270-6474</issn>
<issn pub-type="epub">1529-2401</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21562259</article-id>
<article-id pub-id-type="pmc">3107546</article-id>
<article-id pub-id-type="doi">10.1523/JNEUROSCI.6432-10.2011</article-id>
<article-id pub-id-type="manuscript">NIHMS297391</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Left Parietal regions are critical for adaptive visuomotor control</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Mutha</surname>
<given-names>Pratik K.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sainburg</surname>
<given-names>Robert L.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haaland</surname>
<given-names>Kathleen Y.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
NM VA Healthcare System, Albuquerque, NM 87108</aff>
<aff id="A2"><label>2</label>
Department of Kinesiology, Pennsylvania State University, University Park, PA 16802</aff>
<aff id="A3"><label>3</label>
Department of Neurology, Pennsylvania State University, University Park, PA 16802</aff>
<aff id="A4"><label>4</label>
Program in Neuroscience, Pennsylvania State University, University Park, PA 16802</aff>
<aff id="A5"><label>5</label>
Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131</aff>
<aff id="A6"><label>6</label>
Department of Neurology, University of New Mexico, Albuquerque, NM 87131</aff>
<author-notes><corresp id="CR1"><bold>Corresponding Author:</bold>
Pratik K. Mutha, PhD., NM VA Healthcare System, Research Service 151, 1501 San Pedro Dr. SE, Albuquerque, NM 87108, <email>pkm117@psu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>26</day>
<month>5</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><day>11</day>
<month>5</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>11</day>
<month>11</month>
<year>2011</year>
</pub-date>
<volume>31</volume>
<issue>19</issue>
<fpage>6972</fpage>
<lpage>6981</lpage>
<abstract><p id="P1">The question addressed in this study is whether parietal brain circuits involved in adaptation to novel visuomotor conditions, are lateralized. This information is critical for characterizing the neural mechanisms mediating adaptive behavior in humans, as well as for assessing the effects of unilateral brain damage on function. Moreover, previous research has been controversial in this regard. We compared visuomotor adaptation in 10 patients with focal, unilateral, left or right parietal lesions and healthy control participants. All subjects reached to each of eight targets over three experimental sessions: a baseline session, where the visually-displayed and actual hand motion were matched; an adaptation session where the visual feedback deviated from the actual movement direction by 30-degrees and an after-effect session where visual feedback was again matched to hand motion. Adaptation was primarily quantified as a change in initial movement direction throughout the adaptation session and the presence of after-effects when the rotation was removed. Patients with right parietal damage demonstrated normal adaptation and large after-effects, which was comparable to the performance of healthy controls. In contrast, patients with left parietal damage showed a clear deficit in adaptation and showed no after-effects. Thus, our results show that left, but not right parietal regions are critical for visuomotor adaptation. These findings are discussed in the context that left parietal regions are critical for the modification of stored representations of the relationship between movement commands and limb and environmental state, as is thought to occur during visuomotor adaptation.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source>
<award-id>R01 HD059783-02 || HD</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source>
<award-id>R01 HD039311-09 || HD</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Nouveau-Mexique</li>
<li>Pennsylvanie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Mutha, Pratik K" sort="Mutha, Pratik K" uniqKey="Mutha P" first="Pratik K." last="Mutha">Pratik K. Mutha</name>
</region>
<name sortKey="Haaland, Kathleen Y" sort="Haaland, Kathleen Y" uniqKey="Haaland K" first="Kathleen Y." last="Haaland">Kathleen Y. Haaland</name>
<name sortKey="Haaland, Kathleen Y" sort="Haaland, Kathleen Y" uniqKey="Haaland K" first="Kathleen Y." last="Haaland">Kathleen Y. Haaland</name>
<name sortKey="Haaland, Kathleen Y" sort="Haaland, Kathleen Y" uniqKey="Haaland K" first="Kathleen Y." last="Haaland">Kathleen Y. Haaland</name>
<name sortKey="Mutha, Pratik K" sort="Mutha, Pratik K" uniqKey="Mutha P" first="Pratik K." last="Mutha">Pratik K. Mutha</name>
<name sortKey="Sainburg, Robert L" sort="Sainburg, Robert L" uniqKey="Sainburg R" first="Robert L." last="Sainburg">Robert L. Sainburg</name>
<name sortKey="Sainburg, Robert L" sort="Sainburg, Robert L" uniqKey="Sainburg R" first="Robert L." last="Sainburg">Robert L. Sainburg</name>
<name sortKey="Sainburg, Robert L" sort="Sainburg, Robert L" uniqKey="Sainburg R" first="Robert L." last="Sainburg">Robert L. Sainburg</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A97 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001A97 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:3107546 |texte= Left Parietal regions are critical for adaptive visuomotor control }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:21562259" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |