Limb segment load inhibits post activation depression of soleus H-reflex in humans
Identifieur interne : 001679 ( Pmc/Checkpoint ); précédent : 001678; suivant : 001680Limb segment load inhibits post activation depression of soleus H-reflex in humans
Auteurs : Shih-Chiao Tseng ; Richard K. ShieldsSource :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [ 1388-2457 ] ; 2012.
Abstract
We investigated the effect of various doses of limb segment load on soleus H-reflex amplitude and post activation depression in healthy individuals. We also explored the influence of limb segment load on spinal circuitry in one individual with chronic SCI.
28 healthy adults and one SCI subject received compressive loads applied to the top of their knee at varied doses of load (10%, 25%, and 50% of the body weight). Soleus H-reflexes were measured before (baseline) and during the loading phase.
There were no significant differences in H-reflex amplitudes during the 50 % BW load-on phase as compared to either baseline session or the load-off phase. However, the post activation depression was decreased over 9% (p < 0.05) during the load-on phase compared to the load-off phase and scaled according to load (50%>25%>10%). The post activation depression ratio also appears less responsive to varying loads after chronic SCI.
Limb segment load decreases post-activation depression in humans. These findings suggest that the mechanism associated with post activation depression is modulated by limb segment load, and may be influenced by spinal reorganization after SCI.
Future studies will determine if various levels of spasticity modulate the response of limb segment load on post activation depression in those with acute and chronic SCI.
Url:
DOI: 10.1016/j.clinph.2012.02.068
PubMed: 22418592
PubMed Central: 3380139
Affiliations:
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<author><name sortKey="Tseng, Shih Chiao" sort="Tseng, Shih Chiao" uniqKey="Tseng S" first="Shih-Chiao" last="Tseng">Shih-Chiao Tseng</name>
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<author><name sortKey="Shields, Richard K" sort="Shields, Richard K" uniqKey="Shields R" first="Richard K." last="Shields">Richard K. Shields</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Limb segment load inhibits post activation depression of soleus H-reflex in humans</title>
<author><name sortKey="Tseng, Shih Chiao" sort="Tseng, Shih Chiao" uniqKey="Tseng S" first="Shih-Chiao" last="Tseng">Shih-Chiao Tseng</name>
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<author><name sortKey="Shields, Richard K" sort="Shields, Richard K" uniqKey="Shields R" first="Richard K." last="Shields">Richard K. Shields</name>
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<series><title level="j">Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</title>
<idno type="ISSN">1388-2457</idno>
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<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">We investigated the effect of various doses of limb segment load on soleus H-reflex amplitude and post activation depression in healthy individuals. We also explored the influence of limb segment load on spinal circuitry in one individual with chronic SCI.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">28 healthy adults and one SCI subject received compressive loads applied to the top of their knee at varied doses of load (10%, 25%, and 50% of the body weight). Soleus H-reflexes were measured before (baseline) and during the loading phase.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There were no significant differences in H-reflex amplitudes during the 50 % BW load-on phase as compared to either baseline session or the load-off phase. However, the post activation depression was decreased over 9% (p < 0.05) during the load-on phase compared to the load-off phase and scaled according to load (50%>25%>10%). The post activation depression ratio also appears less responsive to varying loads after chronic SCI.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Limb segment load decreases post-activation depression in humans. These findings suggest that the mechanism associated with post activation depression is modulated by limb segment load, and may be influenced by spinal reorganization after SCI.</p>
</sec>
<sec id="S5"><title>Significance</title>
<p id="P5">Future studies will determine if various levels of spasticity modulate the response of limb segment load on post activation depression in those with acute and chronic SCI.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883319</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21365</journal-id>
<journal-id journal-id-type="nlm-ta">Clin Neurophysiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin Neurophysiol</journal-id>
<journal-title-group><journal-title>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</journal-title>
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<issn pub-type="ppub">1388-2457</issn>
<issn pub-type="epub">1872-8952</issn>
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<article-meta><article-id pub-id-type="pmid">22418592</article-id>
<article-id pub-id-type="pmc">3380139</article-id>
<article-id pub-id-type="doi">10.1016/j.clinph.2012.02.068</article-id>
<article-id pub-id-type="manuscript">NIHMS360141</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Limb segment load inhibits post activation depression of soleus H-reflex in humans</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tseng</surname>
<given-names>Shih-Chiao</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Shields</surname>
<given-names>Richard K.</given-names>
</name>
</contrib>
<aff id="A1">Physical Therapy & Rehabilitation Science Department, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA.</aff>
</contrib-group>
<author-notes><corresp id="cor1"><bold>Corresponding Author:</bold>
Richard K. Shields, PT, PhD, Physical Therapy & Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 Medical Education Building, Iowa City, Iowa 52242, TEL: 319-335-9803, FAX: 319-335-9707, <email>richard-shields@uiowa.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>12</day>
<month>3</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>3</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>9</month>
<year>2013</year>
</pub-date>
<volume>123</volume>
<issue>9</issue>
<fpage>1836</fpage>
<lpage>1845</lpage>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">We investigated the effect of various doses of limb segment load on soleus H-reflex amplitude and post activation depression in healthy individuals. We also explored the influence of limb segment load on spinal circuitry in one individual with chronic SCI.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">28 healthy adults and one SCI subject received compressive loads applied to the top of their knee at varied doses of load (10%, 25%, and 50% of the body weight). Soleus H-reflexes were measured before (baseline) and during the loading phase.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There were no significant differences in H-reflex amplitudes during the 50 % BW load-on phase as compared to either baseline session or the load-off phase. However, the post activation depression was decreased over 9% (p < 0.05) during the load-on phase compared to the load-off phase and scaled according to load (50%>25%>10%). The post activation depression ratio also appears less responsive to varying loads after chronic SCI.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Limb segment load decreases post-activation depression in humans. These findings suggest that the mechanism associated with post activation depression is modulated by limb segment load, and may be influenced by spinal reorganization after SCI.</p>
</sec>
<sec id="S5"><title>Significance</title>
<p id="P5">Future studies will determine if various levels of spasticity modulate the response of limb segment load on post activation depression in those with acute and chronic SCI.</p>
</sec>
</abstract>
<kwd-group><kwd>Compression</kwd>
<kwd>homosynaptic depression</kwd>
<kwd>spinal neural modulation</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source>
<award-id>R01 HD062507-03 || HD</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
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<tree><noCountry><name sortKey="Shields, Richard K" sort="Shields, Richard K" uniqKey="Shields R" first="Richard K." last="Shields">Richard K. Shields</name>
<name sortKey="Tseng, Shih Chiao" sort="Tseng, Shih Chiao" uniqKey="Tseng S" first="Shih-Chiao" last="Tseng">Shih-Chiao Tseng</name>
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