Top-down approach to vestibular compensation: translational lessons from vestibular rehabilitation
Identifieur interne : 001511 ( Pmc/Checkpoint ); précédent : 001510; suivant : 001512Top-down approach to vestibular compensation: translational lessons from vestibular rehabilitation
Auteurs : Carey D. Balaban ; Michael E. Hoffer ; Kim R. GottshallSource :
- Brain research [ 0006-8993 ] ; 2012.
Abstract
This review examines vestibular compensation and vestibular rehabilitation from a unified translational research perspective. Laboratory studies illustrate neurobiological principles of vestibular compensation at the molecular, cellular and systems levels in animal models that inform vestibular rehabilitation practice. However, basic research has been hampered by an emphasis on ‘naturalistic’ recovery, with time after insult and drug interventions as primary dependent variables. The vestibular rehabilitation literature, on the other hand, provides information on how the degree of compensation can be shaped by specific activity regimens. The milestones of the early spontaneous static compensation mark the re-establishment of static gaze stability, which provides a common coordinate frame for the brain to interpret residual vestibular information in the context of visual, somatosensory and visceral signals that convey gravitoinertial information. Stabilization of the head orientation and the eye orientation (suppression of spontaneous nystagmus) appear to be necessary by not sufficient conditions for successful rehabilitation, and define a baseline for initiating retraining. The lessons from vestibular rehabilitation in animal models offer the possibility of shaping the recovery trajectory to identify molecular and genetic factors that can improve vestibular compensation.
Url:
DOI: 10.1016/j.brainres.2012.08.040
PubMed: 22981400
PubMed Central: 3490401
Affiliations:
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0045503</journal-id><journal-id journal-id-type="pubmed-jr-id">1920</journal-id><journal-id journal-id-type="nlm-ta">Brain Res</journal-id><journal-id journal-id-type="iso-abbrev">Brain Res.</journal-id><journal-title-group><journal-title>Brain research</journal-title></journal-title-group><issn pub-type="ppub">0006-8993</issn><issn pub-type="epub">1872-6240</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22981400</article-id><article-id pub-id-type="pmc">3490401</article-id><article-id pub-id-type="doi">10.1016/j.brainres.2012.08.040</article-id><article-id pub-id-type="manuscript">NIHMS405916</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Top-down approach to vestibular compensation: translational lessons from vestibular rehabilitation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balaban</surname><given-names>Carey D.</given-names></name><degrees>PhD</degrees><aff id="A1">Departments of Otolaryngology, Neurobiology, Communication Sciences & Disorders, and Bioengineering, University of Pittsburgh, Pittsburgh, PA USA</aff></contrib><contrib contrib-type="author"><name><surname>Hoffer</surname><given-names>Michael E.</given-names></name><degrees>CAPT MC USN, MD</degrees><aff id="A2">Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA USA</aff></contrib><contrib contrib-type="author"><name><surname>Gottshall</surname><given-names>Kim R.</given-names></name><degrees>PT PhD</degrees><aff id="A3">Director of Vestibular Assessment and Evaluation, Naval Medical Center San Diego, San Diego, CA USA</aff></contrib></contrib-group><author-notes><corresp id="FN1">Correspondence: Carey D. Balaban, PhD, Department of Otolaryngology, University of Pittsburgh, 107 Eye & Ear Institute, 203 Lothrop Street, Pittsburgh, PA 15213 USA, <email>cbalaban@pitt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>6</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="ppub"><day>30</day><month>10</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>10</month><year>2013</year></pub-date><volume>1482C</volume><fpage>101</fpage><lpage>111</lpage><permissions><copyright-statement>© 2012 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P2">This review examines vestibular compensation and vestibular rehabilitation from a unified translational research perspective. Laboratory studies illustrate neurobiological principles of vestibular compensation at the molecular, cellular and systems levels in animal models that inform vestibular rehabilitation practice. However, basic research has been hampered by an emphasis on ‘naturalistic’ recovery, with time after insult and drug interventions as primary dependent variables. The vestibular rehabilitation literature, on the other hand, provides information on how the degree of compensation can be shaped by specific activity regimens. The milestones of the early spontaneous static compensation mark the re-establishment of static gaze stability, which provides a common coordinate frame for the brain to interpret residual vestibular information in the context of visual, somatosensory and visceral signals that convey gravitoinertial information. Stabilization of the head orientation and the eye orientation (suppression of spontaneous nystagmus) appear to be necessary by not sufficient conditions for successful rehabilitation, and define a baseline for initiating retraining. The lessons from vestibular rehabilitation in animal models offer the possibility of shaping the recovery trajectory to identify molecular and genetic factors that can improve vestibular compensation.</p></abstract><kwd-group><kwd>Vestibular compensation</kwd><kwd>vestibular rehabilitation therapy</kwd><kwd>gaze control</kwd><kwd>head control</kwd><kwd>locomotion</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute on Deafness and Other Communication Disorders : NIDCD</funding-source><award-id>R01 DC000739 || DC</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Balaban, Carey D" sort="Balaban, Carey D" uniqKey="Balaban C" first="Carey D." last="Balaban">Carey D. Balaban</name><name sortKey="Gottshall, Kim R" sort="Gottshall, Kim R" uniqKey="Gottshall K" first="Kim R." last="Gottshall">Kim R. Gottshall</name><name sortKey="Hoffer, Michael E" sort="Hoffer, Michael E" uniqKey="Hoffer M" first="Michael E." last="Hoffer">Michael E. Hoffer</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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