A Neural Implementation of Wald's Sequential Probability Ratio Test
Identifieur interne : 000786 ( Pmc/Checkpoint ); précédent : 000785; suivant : 000787A Neural Implementation of Wald's Sequential Probability Ratio Test
Auteurs : Shinichiro Kira [États-Unis] ; Tianming Yang [République populaire de Chine] ; Michael N. Shadlen [États-Unis]Source :
- Neuron [ 0896-6273 ] ; 2015.
Abstract
Difficult decisions often require evaluation of samples of evidence acquired sequentially. A sensible strategy is to accumulate evidence, weighted by its reliability, until sufficient support is attained. An optimal statistical approach would accumulate evidence in units of logarithms of likelihood ratios (logLR) to a desired level. Studies of perceptual decisions suggest that the brain approximates an analogous procedure, but a direct test of accumulation, in units of logLR, to a threshold in units of cumulative logLR is lacking. We trained rhesus monkeys to make decisions based on a sequence of evanescent, visual cues assigned different logLR, hence different reliability. Firing rates of neurons in the lateral intraparietal area (LIP) reflected the accumulation of logLR and reached a stereotyped level before the monkeys committed to a decision. The monkeys’ choices and reaction times, including their variability, were explained by LIP activity in the context of accumulation of logLR to a threshold.
Url:
DOI: 10.1016/j.neuron.2015.01.007
PubMed: 25661183
PubMed Central: 4365451
Affiliations:
- République populaire de Chine, États-Unis
- Washington (État), État de New York
- Université Columbia, Université de Washington
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A sensible strategy is to accumulate evidence, weighted by its reliability, until sufficient support is attained. An optimal statistical approach would accumulate evidence in units of logarithms of likelihood ratios (logLR) to a desired level. Studies of perceptual decisions suggest that the brain approximates an analogous procedure, but a direct test of accumulation, in units of logLR, to a threshold in units of cumulative logLR is lacking. We trained rhesus monkeys to make decisions based on a sequence of evanescent, visual cues assigned different logLR, hence different reliability. Firing rates of neurons in the lateral intraparietal area (LIP) reflected the accumulation of logLR and reached a stereotyped level before the monkeys committed to a decision. The monkeys’ choices and reaction times, including their variability, were explained by LIP activity in the context of accumulation of logLR to a threshold.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8809320</journal-id><journal-id journal-id-type="pubmed-jr-id">1600</journal-id><journal-id journal-id-type="nlm-ta">Neuron</journal-id><journal-id journal-id-type="iso-abbrev">Neuron</journal-id><journal-title-group><journal-title>Neuron</journal-title></journal-title-group><issn pub-type="ppub">0896-6273</issn><issn pub-type="epub">1097-4199</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25661183</article-id><article-id pub-id-type="pmc">4365451</article-id><article-id pub-id-type="doi">10.1016/j.neuron.2015.01.007</article-id><article-id pub-id-type="manuscript">NIHMS662834</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Neural Implementation of Wald's Sequential Probability Ratio Test</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kira</surname><given-names>Shinichiro</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">7</xref><xref ref-type="author-notes" rid="FN2">8</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Tianming</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="author-notes" rid="FN1">7</xref></contrib><contrib contrib-type="author"><name><surname>Shadlen</surname><given-names>Michael N.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Neurobiology & Behavior Program, University of Washington, Seattle, WA 98195, USA</aff><aff id="A2"><label>2</label>Department of Neuroscience, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA</aff><aff id="A3"><label>3</label>Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China</aff><aff id="A4"><label>4</label>Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA</aff><aff id="A5"><label>5</label>Zuckerman Mind Brain Behavior Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA</aff><aff id="A6"><label>6</label>Kavli Institute of Brain Science, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA</aff><author-notes><fn id="FN1"><label>7</label><p id="P1">Co-first author</p></fn><fn fn-type="present-address" id="FN2"><label>8</label><p id="P2">Present address: Department of Neurobiology, Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA</p></fn><corresp id="CR1"><label>*</label>Correspondence: <email>shadlen@columbia.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>05</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>18</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>2</month><year>2016</year></pub-date><volume>85</volume><issue>4</issue><fpage>861</fpage><lpage>873</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.neuron.2015.01.007</pmc-comment>
<permissions><copyright-statement>© 2015 Elsevier Inc.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><title>SUMMARY</title><p id="P3">Difficult decisions often require evaluation of samples of evidence acquired sequentially. A sensible strategy is to accumulate evidence, weighted by its reliability, until sufficient support is attained. An optimal statistical approach would accumulate evidence in units of logarithms of likelihood ratios (logLR) to a desired level. Studies of perceptual decisions suggest that the brain approximates an analogous procedure, but a direct test of accumulation, in units of logLR, to a threshold in units of cumulative logLR is lacking. We trained rhesus monkeys to make decisions based on a sequence of evanescent, visual cues assigned different logLR, hence different reliability. Firing rates of neurons in the lateral intraparietal area (LIP) reflected the accumulation of logLR and reached a stereotyped level before the monkeys committed to a decision. The monkeys’ choices and reaction times, including their variability, were explained by LIP activity in the context of accumulation of logLR to a threshold.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Washington (État)</li><li>État de New York</li></region><orgName><li>Université Columbia</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Kira, Shinichiro" sort="Kira, Shinichiro" uniqKey="Kira S" first="Shinichiro" last="Kira">Shinichiro Kira</name></region><name sortKey="Kira, Shinichiro" sort="Kira, Shinichiro" uniqKey="Kira S" first="Shinichiro" last="Kira">Shinichiro Kira</name><name sortKey="Shadlen, Michael N" sort="Shadlen, Michael N" uniqKey="Shadlen M" first="Michael N." last="Shadlen">Michael N. Shadlen</name><name sortKey="Shadlen, Michael N" sort="Shadlen, Michael N" uniqKey="Shadlen M" first="Michael N." last="Shadlen">Michael N. Shadlen</name><name sortKey="Shadlen, Michael N" sort="Shadlen, Michael N" uniqKey="Shadlen M" first="Michael N." last="Shadlen">Michael N. Shadlen</name><name sortKey="Shadlen, Michael N" sort="Shadlen, Michael N" uniqKey="Shadlen M" first="Michael N." last="Shadlen">Michael N. Shadlen</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Tianming" sort="Yang, Tianming" uniqKey="Yang T" first="Tianming" last="Yang">Tianming Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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