Activity of Somatosensory-Responsive Neurons in High Subdivisions of SI Cortex during Locomotion
Identifieur interne : 000758 ( Pmc/Checkpoint ); précédent : 000757; suivant : 000759Activity of Somatosensory-Responsive Neurons in High Subdivisions of SI Cortex during Locomotion
Auteurs : Oleg V. Favorov [États-Unis] ; Wijitha U. Nilaweera [États-Unis] ; Alexandre A. Miasnikov [États-Unis] ; Irina N. Beloozerova [États-Unis]Source :
- The Journal of Neuroscience [ 0270-6474 ] ; 2015.
Abstract
Responses of neurons in the primary somatosensory cortex during movements are poorly understood, even during such simple tasks as walking on a flat surface. In this study, we analyzed spike discharges of neurons in the rostral bank of the ansate sulcus (areas 1–2) in 2 cats while the cats walked on a flat surface or on a horizontal ladder, a complex task requiring accurate stepping. All neurons (
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DOI: 10.1523/JNEUROSCI.3545-14.2015
PubMed: 25995465
PubMed Central: 4438126
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Responses of neurons in the primary somatosensory cortex during movements are poorly understood, even during such simple tasks as walking on a flat surface. In this study, we analyzed spike discharges of neurons in the rostral bank of the ansate sulcus (areas 1–2) in 2 cats while the cats walked on a flat surface or on a horizontal ladder, a complex task requiring accurate stepping. All neurons (<italic>n</italic>
= 82) that had receptive fields (RFs) on the contralateral forelimb exhibited frequency modulation of their activity that was phase locked to the stride cycle during simple locomotion. Neurons with proximal RFs (upper arm/shoulder) and pyramidal tract-projecting neurons (PTNs) with fast-conducting axons tended to fire at peak rates in the middle of the swing phase, whereas neurons with RFs on the distal limb (wrist/paw) and slow-conducting PTNs typically showed peak firing at the transition between swing and stance phases. Eleven of 12 neurons with tactile RFs on the volar forepaw began firing toward the end of swing, with peak activity occurring at the moment of foot contact with floor, thereby preceding the evoked sensory volley from touch receptors. Requirement to step accurately on the ladder affected 91% of the neurons, suggesting their involvement in control of accuracy of stepping. During both tasks, neurons exhibited a wide variety of spike distributions within the stride cycle, suggesting that, during either simple or ladder locomotion, they represent the cycling somatosensory events in their activity both predictively before and reflectively after these events take place.</p>
</div>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurosci</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Neurosci</journal-id>
<journal-id journal-id-type="hwp">jneuro</journal-id>
<journal-id journal-id-type="pmc">jneurosci</journal-id>
<journal-id journal-id-type="publisher-id">J. Neurosci</journal-id>
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<article-id pub-id-type="doi">10.1523/JNEUROSCI.3545-14.2015</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
<subj-group><subject>Systems/Circuits</subject>
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<title-group><article-title>Activity of Somatosensory-Responsive Neurons in High Subdivisions of SI Cortex during Locomotion</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Favorov</surname>
<given-names>Oleg V.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
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<contrib contrib-type="author"><name><surname>Nilaweera</surname>
<given-names>Wijitha U.</given-names>
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<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
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<contrib contrib-type="author"><name><surname>Miasnikov</surname>
<given-names>Alexandre A.</given-names>
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<xref ref-type="aff" rid="aff4"><sup>4</sup>
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<contrib contrib-type="author" corresp="yes"><name><surname>Beloozerova</surname>
<given-names>Irina N.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
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<aff id="aff1"><sup>1</sup>
Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599,</aff>
<aff id="aff2"><sup>2</sup>
Barrow Neurological Institute, Phoenix, Arizona 85258,</aff>
<aff id="aff3"><sup>3</sup>
Arizona State University–Barrow Neurological Institute Interdisciplinary Graduate Program in Neuroscience, Tempe, Arizona 85281, and</aff>
<aff id="aff4"><sup>4</sup>
Department of Neurobiology and Behavior, Francisco J. Ayala School of Biological Sciences, University of California Irvine, Irvine, California 92697</aff>
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<author-notes><corresp>Correspondence should be addressed to Irina Beloozerova,
<addr-line>Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 350 West Thomas Rd, Phoenix, AZ 85258.</addr-line>
<email>Irina.Beloozerova@thebni.org</email>
</corresp>
<fn fn-type="con"><p>Author contributions: O.V.F., W.U.N., and I.N.B. designed research; O.V.F., W.U.N., and I.N.B. performed research; O.V.F., W.U.N., A.A.M., and I.N.B. analyzed data; O.V.F., W.U.N., and I.N.B. wrote the paper.</p>
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<pub-date pub-type="ppub"><day>20</day>
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<volume>35</volume>
<issue>20</issue>
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<month>8</month>
<year>2014</year>
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<date date-type="rev-recd"><day>14</day>
<month>3</month>
<year>2015</year>
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<date date-type="accepted"><day>7</day>
<month>4</month>
<year>2015</year>
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<permissions><copyright-statement>Copyright © 2015 the authors 0270-6474/15/357763-14$15.00/0</copyright-statement>
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<abstract><p>Responses of neurons in the primary somatosensory cortex during movements are poorly understood, even during such simple tasks as walking on a flat surface. In this study, we analyzed spike discharges of neurons in the rostral bank of the ansate sulcus (areas 1–2) in 2 cats while the cats walked on a flat surface or on a horizontal ladder, a complex task requiring accurate stepping. All neurons (<italic>n</italic>
= 82) that had receptive fields (RFs) on the contralateral forelimb exhibited frequency modulation of their activity that was phase locked to the stride cycle during simple locomotion. Neurons with proximal RFs (upper arm/shoulder) and pyramidal tract-projecting neurons (PTNs) with fast-conducting axons tended to fire at peak rates in the middle of the swing phase, whereas neurons with RFs on the distal limb (wrist/paw) and slow-conducting PTNs typically showed peak firing at the transition between swing and stance phases. Eleven of 12 neurons with tactile RFs on the volar forepaw began firing toward the end of swing, with peak activity occurring at the moment of foot contact with floor, thereby preceding the evoked sensory volley from touch receptors. Requirement to step accurately on the ladder affected 91% of the neurons, suggesting their involvement in control of accuracy of stepping. During both tasks, neurons exhibited a wide variety of spike distributions within the stride cycle, suggesting that, during either simple or ladder locomotion, they represent the cycling somatosensory events in their activity both predictively before and reflectively after these events take place.</p>
</abstract>
<kwd-group><kwd>area 1</kwd>
<kwd>area 2</kwd>
<kwd>cat</kwd>
<kwd>neural coding</kwd>
<kwd>proprioception</kwd>
<kwd>tactile</kwd>
</kwd-group>
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</front>
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<affiliations><list><country><li>États-Unis</li>
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<region><li>Arizona</li>
<li>Californie</li>
<li>Caroline du Nord</li>
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<name sortKey="Beloozerova, Irina N" sort="Beloozerova, Irina N" uniqKey="Beloozerova I" first="Irina N." last="Beloozerova">Irina N. Beloozerova</name>
<name sortKey="Miasnikov, Alexandre A" sort="Miasnikov, Alexandre A" uniqKey="Miasnikov A" first="Alexandre A." last="Miasnikov">Alexandre A. Miasnikov</name>
<name sortKey="Nilaweera, Wijitha U" sort="Nilaweera, Wijitha U" uniqKey="Nilaweera W" first="Wijitha U." last="Nilaweera">Wijitha U. Nilaweera</name>
<name sortKey="Nilaweera, Wijitha U" sort="Nilaweera, Wijitha U" uniqKey="Nilaweera W" first="Wijitha U." last="Nilaweera">Wijitha U. Nilaweera</name>
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