Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis
Identifieur interne : 000483 ( Pmc/Checkpoint ); précédent : 000482; suivant : 000484Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis
Auteurs : Nataliya Brytska ; Ho-Seong Han ; Ahmed Shehta ; Yoo-Seok Yoon ; Jai Young Cho ; Youngrok ChoiSource :
- Hepatobiliary Surgery and Nutrition [ 2304-3881 ] ; 2015.
Abstract
The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.
Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.
The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.
This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.
Url:
DOI: 10.3978/j.issn.2304-3881.2015.04.06
PubMed: 26734621
PubMed Central: 4689694
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis</title><author><name sortKey="Brytska, Nataliya" sort="Brytska, Nataliya" uniqKey="Brytska N" first="Nataliya" last="Brytska">Nataliya Brytska</name></author><author><name sortKey="Han, Ho Seong" sort="Han, Ho Seong" uniqKey="Han H" first="Ho-Seong" last="Han">Ho-Seong Han</name></author><author><name sortKey="Shehta, Ahmed" sort="Shehta, Ahmed" uniqKey="Shehta A" first="Ahmed" last="Shehta">Ahmed Shehta</name></author><author><name sortKey="Yoon, Yoo Seok" sort="Yoon, Yoo Seok" uniqKey="Yoon Y" first="Yoo-Seok" last="Yoon">Yoo-Seok Yoon</name></author><author><name sortKey="Cho, Jai Young" sort="Cho, Jai Young" uniqKey="Cho J" first="Jai Young" last="Cho">Jai Young Cho</name></author><author><name sortKey="Choi, Youngrok" sort="Choi, Youngrok" uniqKey="Choi Y" first="Youngrok" last="Choi">Youngrok Choi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26734621</idno><idno type="pmc">4689694</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689694</idno><idno type="RBID">PMC:4689694</idno><idno type="doi">10.3978/j.issn.2304-3881.2015.04.06</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000095</idno><idno type="wicri:Area/Pmc/Curation">000095</idno><idno type="wicri:Area/Pmc/Checkpoint">000483</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis</title><author><name sortKey="Brytska, Nataliya" sort="Brytska, Nataliya" uniqKey="Brytska N" first="Nataliya" last="Brytska">Nataliya Brytska</name></author><author><name sortKey="Han, Ho Seong" sort="Han, Ho Seong" uniqKey="Han H" first="Ho-Seong" last="Han">Ho-Seong Han</name></author><author><name sortKey="Shehta, Ahmed" sort="Shehta, Ahmed" uniqKey="Shehta A" first="Ahmed" last="Shehta">Ahmed Shehta</name></author><author><name sortKey="Yoon, Yoo Seok" sort="Yoon, Yoo Seok" uniqKey="Yoon Y" first="Yoo-Seok" last="Yoon">Yoo-Seok Yoon</name></author><author><name sortKey="Cho, Jai Young" sort="Cho, Jai Young" uniqKey="Cho J" first="Jai Young" last="Cho">Jai Young Cho</name></author><author><name sortKey="Choi, Youngrok" sort="Choi, Youngrok" uniqKey="Choi Y" first="Youngrok" last="Choi">Youngrok Choi</name></author></analytic><series><title level="j">Hepatobiliary Surgery and Nutrition</title><idno type="ISSN">2304-3881</idno><idno type="eISSN">2304-389X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.</p></sec><sec><title>Methods</title><p>Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.</p></sec><sec><title>Results</title><p>The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.</p></sec><sec><title>Conclusions</title><p>This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hepatobiliary Surg Nutr</journal-id><journal-id journal-id-type="iso-abbrev">Hepatobiliary Surg Nutr</journal-id><journal-id journal-id-type="publisher-id">HBSN</journal-id><journal-title-group><journal-title>Hepatobiliary Surgery and Nutrition</journal-title></journal-title-group><issn pub-type="ppub">2304-3881</issn><issn pub-type="epub">2304-389X</issn><publisher><publisher-name>AME Publishing Company</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26734621</article-id><article-id pub-id-type="pmc">4689694</article-id><article-id pub-id-type="publisher-id">hbsn-04-06-373</article-id><article-id pub-id-type="doi">10.3978/j.issn.2304-3881.2015.04.06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Brytska</surname><given-names>Nataliya</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Han</surname><given-names>Ho-Seong</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shehta</surname><given-names>Ahmed</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yoon</surname><given-names>Yoo-Seok</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Jai Young</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>YoungRok</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff><target id="aff1" target-type="aff"><sup>1</sup></target>Department of Hepatobiliary and Pancreatic Surgery, State Institution “Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine”,<country>Ukraine</country>;<target id="aff2" target-type="aff"><sup>2</sup></target>Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul,<country>South Korea</country>;<target id="aff3" target-type="aff"><sup>3</sup></target>Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura,<country>Egypt</country></aff></contrib-group><author-notes><fn id="afn1"><p><italic>Contributions:</italic> (I) Conception and design: HS Han, N Brytska; (II) Administrative support: None; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.</p></fn><corresp id="cor1"><italic>Correspondence to:</italic> Ho-Seong Han, MD, Ph.D. Professor of Department of Surgery, Seoul National University Bundang Hospital, Seoul National University, College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do463-707, Seoul, South Korea. Email: <email xlink:href="hanhs@snubh.org">hanhs@snubh.org</email>.</corresp></author-notes><pub-date pub-type="epub-ppub"><month>12</month><year>2015</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2015</year></pub-date><volume>4</volume><issue>6</issue><fpage>373</fpage><lpage>378</lpage><history><date date-type="received"><day>04</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>02</day><month>3</month><year>2015</year></date></history><permissions><copyright-statement>2015 Hepatobiliary Surgery and Nutrition. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Hepatobiliary Surgery and Nutrition.</copyright-holder></permissions><abstract><sec><title>Background</title><p>The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.</p></sec><sec><title>Methods</title><p>Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.</p></sec><sec><title>Results</title><p>The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.</p></sec><sec><title>Conclusions</title><p>This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.</p></sec></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>Cirrhosis</kwd><kwd>hepatocellular carcinoma (HCC)</kwd><kwd>laparoscopic liver resection (LLR)</kwd><kwd>survival</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Brytska, Nataliya" sort="Brytska, Nataliya" uniqKey="Brytska N" first="Nataliya" last="Brytska">Nataliya Brytska</name><name sortKey="Cho, Jai Young" sort="Cho, Jai Young" uniqKey="Cho J" first="Jai Young" last="Cho">Jai Young Cho</name><name sortKey="Choi, Youngrok" sort="Choi, Youngrok" uniqKey="Choi Y" first="Youngrok" last="Choi">Youngrok Choi</name><name sortKey="Han, Ho Seong" sort="Han, Ho Seong" uniqKey="Han H" first="Ho-Seong" last="Han">Ho-Seong Han</name><name sortKey="Shehta, Ahmed" sort="Shehta, Ahmed" uniqKey="Shehta A" first="Ahmed" last="Shehta">Ahmed Shehta</name><name sortKey="Yoon, Yoo Seok" sort="Yoon, Yoo Seok" uniqKey="Yoon Y" first="Yoo-Seok" last="Yoon">Yoo-Seok Yoon</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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