Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis
Identifieur interne : 000483 ( Pmc/Checkpoint ); précédent : 000482; suivant : 000484Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis
Auteurs : Nataliya Brytska ; Ho-Seong Han ; Ahmed Shehta ; Yoo-Seok Yoon ; Jai Young Cho ; Youngrok ChoiSource :
- Hepatobiliary Surgery and Nutrition [ 2304-3881 ] ; 2015.
Abstract
The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.
Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.
The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.
This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.
Url:
DOI: 10.3978/j.issn.2304-3881.2015.04.06
PubMed: 26734621
PubMed Central: 4689694
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis</title>
<author><name sortKey="Brytska, Nataliya" sort="Brytska, Nataliya" uniqKey="Brytska N" first="Nataliya" last="Brytska">Nataliya Brytska</name>
</author>
<author><name sortKey="Han, Ho Seong" sort="Han, Ho Seong" uniqKey="Han H" first="Ho-Seong" last="Han">Ho-Seong Han</name>
</author>
<author><name sortKey="Shehta, Ahmed" sort="Shehta, Ahmed" uniqKey="Shehta A" first="Ahmed" last="Shehta">Ahmed Shehta</name>
</author>
<author><name sortKey="Yoon, Yoo Seok" sort="Yoon, Yoo Seok" uniqKey="Yoon Y" first="Yoo-Seok" last="Yoon">Yoo-Seok Yoon</name>
</author>
<author><name sortKey="Cho, Jai Young" sort="Cho, Jai Young" uniqKey="Cho J" first="Jai Young" last="Cho">Jai Young Cho</name>
</author>
<author><name sortKey="Choi, Youngrok" sort="Choi, Youngrok" uniqKey="Choi Y" first="Youngrok" last="Choi">Youngrok Choi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis</title>
<author><name sortKey="Brytska, Nataliya" sort="Brytska, Nataliya" uniqKey="Brytska N" first="Nataliya" last="Brytska">Nataliya Brytska</name>
</author>
<author><name sortKey="Han, Ho Seong" sort="Han, Ho Seong" uniqKey="Han H" first="Ho-Seong" last="Han">Ho-Seong Han</name>
</author>
<author><name sortKey="Shehta, Ahmed" sort="Shehta, Ahmed" uniqKey="Shehta A" first="Ahmed" last="Shehta">Ahmed Shehta</name>
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<author><name sortKey="Yoon, Yoo Seok" sort="Yoon, Yoo Seok" uniqKey="Yoon Y" first="Yoo-Seok" last="Yoon">Yoo-Seok Yoon</name>
</author>
<author><name sortKey="Cho, Jai Young" sort="Cho, Jai Young" uniqKey="Cho J" first="Jai Young" last="Cho">Jai Young Cho</name>
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<author><name sortKey="Choi, Youngrok" sort="Choi, Youngrok" uniqKey="Choi Y" first="Youngrok" last="Choi">Youngrok Choi</name>
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<series><title level="j">Hepatobiliary Surgery and Nutrition</title>
<idno type="ISSN">2304-3881</idno>
<idno type="eISSN">2304-389X</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.</p>
</sec>
<sec><title>Methods</title>
<p>Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.</p>
</sec>
<sec><title>Results</title>
<p>The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hepatobiliary Surg Nutr</journal-id>
<journal-id journal-id-type="iso-abbrev">Hepatobiliary Surg Nutr</journal-id>
<journal-id journal-id-type="publisher-id">HBSN</journal-id>
<journal-title-group><journal-title>Hepatobiliary Surgery and Nutrition</journal-title>
</journal-title-group>
<issn pub-type="ppub">2304-3881</issn>
<issn pub-type="epub">2304-389X</issn>
<publisher><publisher-name>AME Publishing Company</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26734621</article-id>
<article-id pub-id-type="pmc">4689694</article-id>
<article-id pub-id-type="publisher-id">hbsn-04-06-373</article-id>
<article-id pub-id-type="doi">10.3978/j.issn.2304-3881.2015.04.06</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Brytska</surname>
<given-names>Nataliya</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Han</surname>
<given-names>Ho-Seong</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shehta</surname>
<given-names>Ahmed</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yoon</surname>
<given-names>Yoo-Seok</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cho</surname>
<given-names>Jai Young</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>YoungRok</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<aff><target id="aff1" target-type="aff"><sup>1</sup>
</target>
Department of Hepatobiliary and Pancreatic Surgery, State Institution “Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine”,<country>Ukraine</country>
;<target id="aff2" target-type="aff"><sup>2</sup>
</target>
Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul,<country>South Korea</country>
;<target id="aff3" target-type="aff"><sup>3</sup>
</target>
Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura,<country>Egypt</country>
</aff>
</contrib-group>
<author-notes><fn id="afn1"><p><italic>Contributions:</italic>
(I) Conception and design: HS Han, N Brytska; (II) Administrative support: None; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.</p>
</fn>
<corresp id="cor1"><italic>Correspondence to:</italic>
Ho-Seong Han, MD, Ph.D. Professor of Department of Surgery, Seoul National University Bundang Hospital, Seoul National University, College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do463-707, Seoul, South Korea. Email: <email xlink:href="hanhs@snubh.org">hanhs@snubh.org</email>
.</corresp>
</author-notes>
<pub-date pub-type="epub-ppub"><month>12</month>
<year>2015</year>
</pub-date>
<pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>12</month>
<year>2015</year>
</pub-date>
<volume>4</volume>
<issue>6</issue>
<fpage>373</fpage>
<lpage>378</lpage>
<history><date date-type="received"><day>04</day>
<month>12</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>02</day>
<month>3</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>2015 Hepatobiliary Surgery and Nutrition. All rights reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Hepatobiliary Surgery and Nutrition.</copyright-holder>
</permissions>
<abstract><sec><title>Background</title>
<p>The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.</p>
</sec>
<sec><title>Methods</title>
<p>Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.</p>
</sec>
<sec><title>Results</title>
<p>The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords: </title>
<kwd>Cirrhosis</kwd>
<kwd>hepatocellular carcinoma (HCC)</kwd>
<kwd>laparoscopic liver resection (LLR)</kwd>
<kwd>survival</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Brytska, Nataliya" sort="Brytska, Nataliya" uniqKey="Brytska N" first="Nataliya" last="Brytska">Nataliya Brytska</name>
<name sortKey="Cho, Jai Young" sort="Cho, Jai Young" uniqKey="Cho J" first="Jai Young" last="Cho">Jai Young Cho</name>
<name sortKey="Choi, Youngrok" sort="Choi, Youngrok" uniqKey="Choi Y" first="Youngrok" last="Choi">Youngrok Choi</name>
<name sortKey="Han, Ho Seong" sort="Han, Ho Seong" uniqKey="Han H" first="Ho-Seong" last="Han">Ho-Seong Han</name>
<name sortKey="Shehta, Ahmed" sort="Shehta, Ahmed" uniqKey="Shehta A" first="Ahmed" last="Shehta">Ahmed Shehta</name>
<name sortKey="Yoon, Yoo Seok" sort="Yoon, Yoo Seok" uniqKey="Yoon Y" first="Yoo-Seok" last="Yoon">Yoo-Seok Yoon</name>
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</affiliations>
</record>
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