Xenobiotic and Endobiotic Mediated Interactions between the Cytochrome P450 System and the Inflammatory Response In the Liver
Identifieur interne : 000192 ( Pmc/Checkpoint ); précédent : 000191; suivant : 000193Xenobiotic and Endobiotic Mediated Interactions between the Cytochrome P450 System and the Inflammatory Response In the Liver
Auteurs : Benjamin L. Woolbright ; Hartmut JaeschkeSource :
- Advances in pharmacology (San Diego, Calif.) [ 1054-3589 ] ; 2015.
Abstract
The liver is a unique organ in the body as it has significant roles in both metabolism and innate immune clearance. Hepatocytes in the liver carry a nearly complete complement of drug metabolizing enzymes, including numerous cytochrome P450s. While a majority of these enzymes effectively detoxify xenobiotics, or metabolize endobiotics, a sub-portion of these reactions result in accumulation of metabolites that can cause either direct liver injury or indirect liver injury through activation of inflammation. The liver also contains multiple populations of innate immune cells including the resident macrophages (Kupffer cells), a relatively large number of natural killer cells, and blood-derived neutrophils. While these cells are primarily responsible for clearance of pathogens, activation of these immune cells can result in significant tissue injury during periods of inflammation. When activated chronically, these inflammatory bouts can lead to fibrosis, cirrhosis, cancer or death. This Chapter will focus on interactions between how the liver processes xenobiotic and endobiotic compounds through the cytochrome P450 system, and how these processes can result in a response from the innate immune cells of the liver. A number of different clinically relevant diseases, as well as experimental models, are currently available to study mechanisms related to the interplay of innate immunity and cytochrome P450 mediated metabolism. A major focus of the chapter will be to evaluate currently understood mechanisms in the context of these diseases as a way of outlining mechanisms that dictate the interactions between the P450 system and innate immunity.
Url:
DOI: 10.1016/bs.apha.2015.04.001
PubMed: 26233906
PubMed Central: 4665978
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4665978Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Xenobiotic and Endobiotic Mediated Interactions between the Cytochrome P450 System and the Inflammatory Response In the Liver</title>
<author><name sortKey="Woolbright, Benjamin L" sort="Woolbright, Benjamin L" uniqKey="Woolbright B" first="Benjamin L." last="Woolbright">Benjamin L. Woolbright</name>
</author>
<author><name sortKey="Jaeschke, Hartmut" sort="Jaeschke, Hartmut" uniqKey="Jaeschke H" first="Hartmut" last="Jaeschke">Hartmut Jaeschke</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26233906</idno>
<idno type="pmc">4665978</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665978</idno>
<idno type="RBID">PMC:4665978</idno>
<idno type="doi">10.1016/bs.apha.2015.04.001</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001A63</idno>
<idno type="wicri:Area/Pmc/Curation">001A63</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000192</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Xenobiotic and Endobiotic Mediated Interactions between the Cytochrome P450 System and the Inflammatory Response In the Liver</title>
<author><name sortKey="Woolbright, Benjamin L" sort="Woolbright, Benjamin L" uniqKey="Woolbright B" first="Benjamin L." last="Woolbright">Benjamin L. Woolbright</name>
</author>
<author><name sortKey="Jaeschke, Hartmut" sort="Jaeschke, Hartmut" uniqKey="Jaeschke H" first="Hartmut" last="Jaeschke">Hartmut Jaeschke</name>
</author>
</analytic>
<series><title level="j">Advances in pharmacology (San Diego, Calif.)</title>
<idno type="ISSN">1054-3589</idno>
<idno type="eISSN">1557-8925</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The liver is a unique organ in the body as it has significant roles in both metabolism and innate immune clearance. Hepatocytes in the liver carry a nearly complete complement of drug metabolizing enzymes, including numerous cytochrome P450s. While a majority of these enzymes effectively detoxify xenobiotics, or metabolize endobiotics, a sub-portion of these reactions result in accumulation of metabolites that can cause either direct liver injury or indirect liver injury through activation of inflammation. The liver also contains multiple populations of innate immune cells including the resident macrophages (Kupffer cells), a relatively large number of natural killer cells, and blood-derived neutrophils. While these cells are primarily responsible for clearance of pathogens, activation of these immune cells can result in significant tissue injury during periods of inflammation. When activated chronically, these inflammatory bouts can lead to fibrosis, cirrhosis, cancer or death. This Chapter will focus on interactions between how the liver processes xenobiotic and endobiotic compounds through the cytochrome P450 system, and how these processes can result in a response from the innate immune cells of the liver. A number of different clinically relevant diseases, as well as experimental models, are currently available to study mechanisms related to the interplay of innate immunity and cytochrome P450 mediated metabolism. A major focus of the chapter will be to evaluate currently understood mechanisms in the context of these diseases as a way of outlining mechanisms that dictate the interactions between the P450 system and innate immunity.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9015397</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1826</journal-id>
<journal-id journal-id-type="nlm-ta">Adv Pharmacol</journal-id>
<journal-id journal-id-type="iso-abbrev">Adv. Pharmacol.</journal-id>
<journal-title-group><journal-title>Advances in pharmacology (San Diego, Calif.)</journal-title>
</journal-title-group>
<issn pub-type="ppub">1054-3589</issn>
<issn pub-type="epub">1557-8925</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26233906</article-id>
<article-id pub-id-type="pmc">4665978</article-id>
<article-id pub-id-type="doi">10.1016/bs.apha.2015.04.001</article-id>
<article-id pub-id-type="manuscript">NIHMS733630</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Xenobiotic and Endobiotic Mediated Interactions between the Cytochrome P450 System and the Inflammatory Response In the Liver</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Woolbright</surname>
<given-names>Benjamin L.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jaeschke</surname>
<given-names>Hartmut</given-names>
</name>
<email>hjaeschke@kumc.edu</email>
</contrib>
<aff id="A1">Department of Pharmacology, Toxicology and Therapeutics, Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States of America</aff>
</contrib-group>
<author-notes><corresp id="cor1"><bold>For Correspondence:</bold>
Hartmut Jaeschke, Ph.D., Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, Tel. 913 588 7969, Fax 913 588 7501, <email>hjaeschke@kumc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>22</day>
<month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>19</day>
<month>5</month>
<year>2016</year>
</pub-date>
<volume>74</volume>
<fpage>131</fpage>
<lpage>161</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/bs.apha.2015.04.001</pmc-comment>
<abstract><p id="P1">The liver is a unique organ in the body as it has significant roles in both metabolism and innate immune clearance. Hepatocytes in the liver carry a nearly complete complement of drug metabolizing enzymes, including numerous cytochrome P450s. While a majority of these enzymes effectively detoxify xenobiotics, or metabolize endobiotics, a sub-portion of these reactions result in accumulation of metabolites that can cause either direct liver injury or indirect liver injury through activation of inflammation. The liver also contains multiple populations of innate immune cells including the resident macrophages (Kupffer cells), a relatively large number of natural killer cells, and blood-derived neutrophils. While these cells are primarily responsible for clearance of pathogens, activation of these immune cells can result in significant tissue injury during periods of inflammation. When activated chronically, these inflammatory bouts can lead to fibrosis, cirrhosis, cancer or death. This Chapter will focus on interactions between how the liver processes xenobiotic and endobiotic compounds through the cytochrome P450 system, and how these processes can result in a response from the innate immune cells of the liver. A number of different clinically relevant diseases, as well as experimental models, are currently available to study mechanisms related to the interplay of innate immunity and cytochrome P450 mediated metabolism. A major focus of the chapter will be to evaluate currently understood mechanisms in the context of these diseases as a way of outlining mechanisms that dictate the interactions between the P450 system and innate immunity.</p>
</abstract>
<kwd-group><kwd>Inflammation</kwd>
<kwd>cytochrome P450</kwd>
<kwd>CYP7A1</kwd>
<kwd>alcohol</kwd>
<kwd>neutrophil</kwd>
<kwd>acetaminophen</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Jaeschke, Hartmut" sort="Jaeschke, Hartmut" uniqKey="Jaeschke H" first="Hartmut" last="Jaeschke">Hartmut Jaeschke</name>
<name sortKey="Woolbright, Benjamin L" sort="Woolbright, Benjamin L" uniqKey="Woolbright B" first="Benjamin L." last="Woolbright">Benjamin L. Woolbright</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000192 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000192 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:4665978 |texte= Xenobiotic and Endobiotic Mediated Interactions between the Cytochrome P450 System and the Inflammatory Response In the Liver }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:26233906" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |