The aim of this study was to detect qualitative changes in the structure of coordinative variable (elbow angle) fluctuations during a quasi-isometric exercise performed until exhaustion. Seven physical education students performed a quasi-isometric arm-curl exercise holding an Olympic bar (weight: 80% 1RM) with an initial elbow flexion of 90° three times over a period of 4 weeks. They were encouraged to persist, even if the elbow angle was lost, until the fatigue-induced spontaneous termination point (FISTP). Changes in both elbow angles were registered during the task through an electrogoniometer. Detrended Fluctuation Analysis (DFA) was conducted on the initial and final 1024 data points of the series and the associated Hurst exponents were obtained. Multi-way RM ANOVA analyses revealed a significant main effect of the Time on task on the Hurst exponent values but also revealed a significant Trial × Time on task interaction. In the initial (non-fatigue) condition participants tended to produce anti-persistent fBm fluctuations. In the final part before exhaustion a tendency toward persistent fBm was dominant. The trial to trial differences in time-variability structure points to an existence of a long-term variability in control strategies during exercise. The changes in the temporal structure of the elbow angle variability as effort accumulated reflected an increase in low-frequency fluctuations signifying a change in psychobiological mechanisms used to negotiate the task demands. The variability properties of the coordinative variable during exercise may provide information about the dynamic mechanisms that lead to exhaustion.