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Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses

Identifieur interne : 000625 ( PascalFrancis/Curation ); précédent : 000624; suivant : 000626

Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses

Auteurs : Catherine J. Heatley [Royaume-Uni] ; David J. Spalton [Royaume-Uni] ; Anupma Kumar [Royaume-Uni] ; Romina Jose [Royaume-Uni] ; James Boyce [Royaume-Uni] ; Lloyd E. Bender [Royaume-Uni]

Source :

RBID : Pascal:05-0285212

Descripteurs français

English descriptors

Abstract

Purpose: To determine the effect of intraocular lens (IOL) material on the development of posterior capsule opacification (PCO) at 1 year. Setting: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. Methods: One hundred six eyes of 53 patients with bilateral cataract and no other ocular comorbidity were prospectively randomized to receive a hydrophobic acrylic or hydrophilic acrylic single-piece IOL in the first eye to have surgery. The alternate IOL was implanted in the fellow eye 4 to 6 weeks later. All surgery was performed by a single surgeon. Postoperative follow-up was 1 day, 1 and 6 months, and 1 year. At each visit, the best corrected high- and low-contrast visual acuities were assessed and a high-intensity digital retroillumination photograph was taken. Posterior capsule opacification was assessed from the digital images by a single operator using a dedicated software program and calculated as the percentage area of opacified capsule. Results: One year postoperatively, the median percentage area of PCO was 50.3% in the hydrophilic IOL group and 4.9% in the hydrophobic IOL group (P<.001). The difference in PCO was not accounted for by loss of contact between the capsulorhexis and IOL surface. Further analysis showed that lens epithelial cells tended to invade the posterior capsule at the haptic-optic junction. This was more marked in the hydrophilic IOL group. Conclusions: The rate of PCO was significantly higher with the hydrophilic IOL. However, the results cannot be attributed to the IOL material alone as they show the importance of both IOL material and design.
pA  
A01 01  1    @0 0886-3350
A02 01      @0 JCSUEV
A03   1    @0 J. cataract refractive surg.
A05       @2 31
A06       @2 4
A08 01  1  ENG  @1 Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses
A11 01  1    @1 HEATLEY (Catherine J.)
A11 02  1    @1 SPALTON (David J.)
A11 03  1    @1 KUMAR (Anupma)
A11 04  1    @1 JOSE (Romina)
A11 05  1    @1 BOYCE (James)
A11 06  1    @1 BENDER (Lloyd E.)
A14 01      @1 Department of Ophthalmology, St. Thomas' Hospital @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 6 aut.
A14 02      @1 Department of Physics, Kings College London @2 London @3 GBR @Z 4 aut. @Z 5 aut.
A20       @1 718-724
A21       @1 2005
A23 01      @0 ENG
A43 01      @1 INIST @2 20937 @5 354000138053470100
A44       @0 0000 @1 © 2005 INIST-CNRS. All rights reserved.
A45       @0 28 ref.
A47 01  1    @0 05-0285212
A60       @1 P
A61       @0 A
A64 01  1    @0 Journal of cataract and refractive surgery
A66 01      @0 USA
C01 01    ENG  @0 Purpose: To determine the effect of intraocular lens (IOL) material on the development of posterior capsule opacification (PCO) at 1 year. Setting: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. Methods: One hundred six eyes of 53 patients with bilateral cataract and no other ocular comorbidity were prospectively randomized to receive a hydrophobic acrylic or hydrophilic acrylic single-piece IOL in the first eye to have surgery. The alternate IOL was implanted in the fellow eye 4 to 6 weeks later. All surgery was performed by a single surgeon. Postoperative follow-up was 1 day, 1 and 6 months, and 1 year. At each visit, the best corrected high- and low-contrast visual acuities were assessed and a high-intensity digital retroillumination photograph was taken. Posterior capsule opacification was assessed from the digital images by a single operator using a dedicated software program and calculated as the percentage area of opacified capsule. Results: One year postoperatively, the median percentage area of PCO was 50.3% in the hydrophilic IOL group and 4.9% in the hydrophobic IOL group (P<.001). The difference in PCO was not accounted for by loss of contact between the capsulorhexis and IOL surface. Further analysis showed that lens epithelial cells tended to invade the posterior capsule at the haptic-optic junction. This was more marked in the hydrophilic IOL group. Conclusions: The rate of PCO was significantly higher with the hydrophilic IOL. However, the results cannot be attributed to the IOL material alone as they show the importance of both IOL material and design.
C02 01  X    @0 002B25B
C03 01  X  FRE  @0 Etude comparative @5 02
C03 01  X  ENG  @0 Comparative study @5 02
C03 01  X  SPA  @0 Estudio comparativo @5 02
C03 02  X  FRE  @0 Postérieur @5 03
C03 02  X  ENG  @0 Posterior @5 03
C03 02  X  SPA  @0 Posterior @5 03
C03 03  X  FRE  @0 Capsule @5 05
C03 03  X  ENG  @0 Capsule @5 05
C03 03  X  SPA  @0 Cápsula @5 05
C03 04  X  FRE  @0 Opacification @5 06
C03 04  X  ENG  @0 Opacification @5 06
C03 04  X  SPA  @0 Opacificación @5 06
C03 05  X  FRE  @0 Taux @5 08
C03 05  X  ENG  @0 Rate @5 08
C03 05  X  SPA  @0 Tasa @5 08
C03 06  X  FRE  @0 Hydrophilie @5 09
C03 06  X  ENG  @0 Hydrophily @5 09
C03 06  X  SPA  @0 Hidrofilia @5 09
C03 07  X  FRE  @0 Lentille intraoculaire @5 11
C03 07  X  ENG  @0 Intraocular lens @5 11
C03 07  X  SPA  @0 Lente intraocular @5 11
C03 08  X  FRE  @0 Chirurgie @5 12
C03 08  X  ENG  @0 Surgery @5 12
C03 08  X  SPA  @0 Cirugía @5 12
C03 09  X  FRE  @0 Ophtalmologie @5 14
C03 09  X  ENG  @0 Ophthalmology @5 14
C03 09  X  SPA  @0 Oftalmología @5 14
N21       @1 199
N44 01      @1 OTO
N82       @1 OTO

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<term>Rate</term>
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<div type="abstract" xml:lang="en">Purpose: To determine the effect of intraocular lens (IOL) material on the development of posterior capsule opacification (PCO) at 1 year. Setting: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. Methods: One hundred six eyes of 53 patients with bilateral cataract and no other ocular comorbidity were prospectively randomized to receive a hydrophobic acrylic or hydrophilic acrylic single-piece IOL in the first eye to have surgery. The alternate IOL was implanted in the fellow eye 4 to 6 weeks later. All surgery was performed by a single surgeon. Postoperative follow-up was 1 day, 1 and 6 months, and 1 year. At each visit, the best corrected high- and low-contrast visual acuities were assessed and a high-intensity digital retroillumination photograph was taken. Posterior capsule opacification was assessed from the digital images by a single operator using a dedicated software program and calculated as the percentage area of opacified capsule. Results: One year postoperatively, the median percentage area of PCO was 50.3% in the hydrophilic IOL group and 4.9% in the hydrophobic IOL group (P<.001). The difference in PCO was not accounted for by loss of contact between the capsulorhexis and IOL surface. Further analysis showed that lens epithelial cells tended to invade the posterior capsule at the haptic-optic junction. This was more marked in the hydrophilic IOL group. Conclusions: The rate of PCO was significantly higher with the hydrophilic IOL. However, the results cannot be attributed to the IOL material alone as they show the importance of both IOL material and design.</div>
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<s0>Purpose: To determine the effect of intraocular lens (IOL) material on the development of posterior capsule opacification (PCO) at 1 year. Setting: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. Methods: One hundred six eyes of 53 patients with bilateral cataract and no other ocular comorbidity were prospectively randomized to receive a hydrophobic acrylic or hydrophilic acrylic single-piece IOL in the first eye to have surgery. The alternate IOL was implanted in the fellow eye 4 to 6 weeks later. All surgery was performed by a single surgeon. Postoperative follow-up was 1 day, 1 and 6 months, and 1 year. At each visit, the best corrected high- and low-contrast visual acuities were assessed and a high-intensity digital retroillumination photograph was taken. Posterior capsule opacification was assessed from the digital images by a single operator using a dedicated software program and calculated as the percentage area of opacified capsule. Results: One year postoperatively, the median percentage area of PCO was 50.3% in the hydrophilic IOL group and 4.9% in the hydrophobic IOL group (P<.001). The difference in PCO was not accounted for by loss of contact between the capsulorhexis and IOL surface. Further analysis showed that lens epithelial cells tended to invade the posterior capsule at the haptic-optic junction. This was more marked in the hydrophilic IOL group. Conclusions: The rate of PCO was significantly higher with the hydrophilic IOL. However, the results cannot be attributed to the IOL material alone as they show the importance of both IOL material and design.</s0>
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