Anterior capsule opacification : A histopathological study comparing different IOL styles
Identifieur interne : 001487 ( PascalFrancis/Corpus ); précédent : 001486; suivant : 001488Anterior capsule opacification : A histopathological study comparing different IOL styles
Auteurs : L. Werner ; S. K. Pandey ; M. Escobar-Gomez ; N. Visessook ; QUN PENG ; D. J. AppleSource :
- Ophthalmology : (Rochester, MN) [ 0161-6420 ] ; 2000.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: To compare the degree of anterior capsule opacification (ACO) in human eyes obtained post-mortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs. Design: Comparative autopsy tissue study with clinicopathologic correlations. Materials: Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50)r (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92). Testing: The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome stains; and examined by light microscopy. Main Outcome Measures: Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin. Results: The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52). Conclusions: Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone lOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.
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Format Inist (serveur)
NO : | PASCAL 00-0172600 INIST |
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ET : | Anterior capsule opacification : A histopathological study comparing different IOL styles |
AU : | WERNER (L.); PANDEY (S. K.); ESCOBAR-GOMEZ (M.); VISESSOOK (N.); QUN PENG; APPLE (D. J.) |
AF : | Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina/Charleston, South Carolina/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Ophthalmology : (Rochester, MN); ISSN 0161-6420; Coden OPHTDG; Etats-Unis; Da. 2000; Vol. 107; No. 3; Pp. 463-471; Bibl. 40 ref. |
LA : | Anglais |
EA : | Objective: To compare the degree of anterior capsule opacification (ACO) in human eyes obtained post-mortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs. Design: Comparative autopsy tissue study with clinicopathologic correlations. Materials: Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50)r (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92). Testing: The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome stains; and examined by light microscopy. Main Outcome Measures: Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin. Results: The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52). Conclusions: Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone lOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO. |
CC : | 002B25B |
FD : | Lentille intraoculaire; Oeil; Biomatériau; Siloxane polymère; Méthacrylate de méthyle polymère; Etude comparative; Opacification; Capsule; Antérieur; Histopathologie; Autopsie; Homme |
FG : | Chirurgie; Oeil pathologie |
ED : | Intraocular lens; Eye; Biomaterial; Siloxane polymer; Methyl methacrylate polymer; Comparative study; Opacification; Capsule; Anterior; Histopathology; Autopsy; Human |
EG : | Surgery; Eye disease |
SD : | Lente intraocular; Ojo; Biomaterial; Siloxano polímero; Metacrilato de metilo polímero; Estudio comparativo; Opacificación; Cápsula; Anterior; Histopatología; Autopsia; Hombre |
LO : | INIST-18914.354000081967510130 |
ID : | 00-0172600 |
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Pascal:00-0172600Le document en format XML
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<term>Eye</term>
<term>Histopathology</term>
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<term>Etude comparative</term>
<term>Opacification</term>
<term>Capsule</term>
<term>Antérieur</term>
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<front><div type="abstract" xml:lang="en">Objective: To compare the degree of anterior capsule opacification (ACO) in human eyes obtained post-mortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs. Design: Comparative autopsy tissue study with clinicopathologic correlations. Materials: Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50)<sub>r</sub>
(2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92). Testing: The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome stains; and examined by light microscopy. Main Outcome Measures: Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin. Results: The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52). Conclusions: Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone lOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</div>
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(2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92). Testing: The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome stains; and examined by light microscopy. Main Outcome Measures: Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin. Results: The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52). Conclusions: Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone lOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</s0>
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<fC03 i1="11" i2="X" l="SPA"><s0>Autopsia</s0>
<s5>11</s5>
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<fC03 i1="12" i2="X" l="FRE"><s0>Homme</s0>
<s5>13</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>37</s5>
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<fC07 i1="02" i2="X" l="FRE"><s0>Oeil pathologie</s0>
<s5>53</s5>
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<s5>53</s5>
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<server><NO>PASCAL 00-0172600 INIST</NO>
<ET>Anterior capsule opacification : A histopathological study comparing different IOL styles</ET>
<AU>WERNER (L.); PANDEY (S. K.); ESCOBAR-GOMEZ (M.); VISESSOOK (N.); QUN PENG; APPLE (D. J.)</AU>
<AF>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina/Charleston, South Carolina/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Ophthalmology : (Rochester, MN); ISSN 0161-6420; Coden OPHTDG; Etats-Unis; Da. 2000; Vol. 107; No. 3; Pp. 463-471; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: To compare the degree of anterior capsule opacification (ACO) in human eyes obtained post-mortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs. Design: Comparative autopsy tissue study with clinicopathologic correlations. Materials: Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50)<sub>r</sub>
(2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92). Testing: The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome stains; and examined by light microscopy. Main Outcome Measures: Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin. Results: The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52). Conclusions: Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone lOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</EA>
<CC>002B25B</CC>
<FD>Lentille intraoculaire; Oeil; Biomatériau; Siloxane polymère; Méthacrylate de méthyle polymère; Etude comparative; Opacification; Capsule; Antérieur; Histopathologie; Autopsie; Homme</FD>
<FG>Chirurgie; Oeil pathologie</FG>
<ED>Intraocular lens; Eye; Biomaterial; Siloxane polymer; Methyl methacrylate polymer; Comparative study; Opacification; Capsule; Anterior; Histopathology; Autopsy; Human</ED>
<EG>Surgery; Eye disease</EG>
<SD>Lente intraocular; Ojo; Biomaterial; Siloxano polímero; Metacrilato de metilo polímero; Estudio comparativo; Opacificación; Cápsula; Anterior; Histopatología; Autopsia; Hombre</SD>
<LO>INIST-18914.354000081967510130</LO>
<ID>00-0172600</ID>
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