Hydrophilic acrylic intraocular lens optic and haptics Opacification in a diabetic patient bilateral case report and clinicopathologic correlation
Identifieur interne : 000F68 ( PascalFrancis/Checkpoint ); précédent : 000F67; suivant : 000F69Hydrophilic acrylic intraocular lens optic and haptics Opacification in a diabetic patient bilateral case report and clinicopathologic correlation
Auteurs : Suresh K. Pandey [États-Unis] ; Liliana Werner [États-Unis] ; David J. Apple [États-Unis] ; Mahmut Kaskaloglu [Turquie]Source :
- Ophthalmology : (Rochester, MN) [ 0161-6420 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Diabète, Biomatériau, Personne âgée.
English descriptors
- KwdEn :
Abstract
Objective: To report clinicopathologic and ultrastructural features of two opacified single-piece hydrophilic acrylic intraocular lenses (lOLs) explanted from a diabetic patient. Design: Interventional case report with clinicopathologic correlation. Setting: A 64-year-old white female underwent phacoemulsification and implantation of a single-piece hydrophilic acrylic lens (SC60B-OUV; Medical Developmental Research, Inc., Clear Water, FL) in October 1998 in the left eye and in July 1999 in the right eye. The best-corrected visual acuity after surgery was 20/60 in the left eye and 20/50 in the right eye. The patient had a marked decrease in visual acuity in June 2000 as a result of a milky, white opalescence of both lenses. Intraocular lens explantation and exchange was performed in both eyes and the explanted lOLs were submitted to our center for detailed pathologic, histochemical, and ultrastructural evaluation. They were stained with alizarin red and the von Kossa method for calcium, and also underwent scanning electron microscopy and energy dispersive radiograph spectroscopy to ascertain the nature of the deposits leading to opacification. Main Outcome Measures: Documentation of calcium deposits confirmed by histochemical stains and surface analyses. Results: Opacification of the IOL was found to be the cause of decreased visual acuity. The opacification involved both the IOL optic and the haptics in the left eye and was confined to the IOL optic in the right eye. Histochemical and ultrastructural analyses revealed that the opacity was caused by deposition of calcium and phosphate within the lens optic and haptics. Conclusions: There are two features that distinguish this case from those reported earlier. This is the first clinicopathologic report of lens opacification that has involved completely the lens optic and the haptics. Second, these two explanted lOLs document the first bilateral case. This process of intraoptic and haptic opacification represents dystrophic calcification of unknown cause. Diabetic patients appear to be more severely and more often affected by lens opacification. Long-term follow-up of diabetic patients implanted with this IOL design should be maintained by surgeons and manufacturers.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:03-0137391Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Hydrophilic acrylic intraocular lens optic and haptics Opacification in a diabetic patient bilateral case report and clinicopathologic correlation</title><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J." last="Apple">David J. Apple</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Kaskaloglu, Mahmut" sort="Kaskaloglu, Mahmut" uniqKey="Kaskaloglu M" first="Mahmut" last="Kaskaloglu">Mahmut Kaskaloglu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ege University</s1><s2>Alsancak Izmir</s2><s3>TUR</s3><sZ>4 aut.</sZ></inist:fA14><country>Turquie</country><wicri:noRegion>Ege University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0137391</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 03-0137391 INIST</idno><idno type="RBID">Pascal:03-0137391</idno><idno type="wicri:Area/PascalFrancis/Corpus">001198</idno><idno type="wicri:Area/PascalFrancis/Curation">000313</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hydrophilic acrylic intraocular lens optic and haptics Opacification in a diabetic patient bilateral case report and clinicopathologic correlation</title><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J." last="Apple">David J. Apple</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Kaskaloglu, Mahmut" sort="Kaskaloglu, Mahmut" uniqKey="Kaskaloglu M" first="Mahmut" last="Kaskaloglu">Mahmut Kaskaloglu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ege University</s1><s2>Alsancak Izmir</s2><s3>TUR</s3><sZ>4 aut.</sZ></inist:fA14><country>Turquie</country><wicri:noRegion>Ege University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Ophthalmology : (Rochester, MN)</title><title level="j" type="abbreviated">Ophthalmology : (Rochester MN)</title><idno type="ISSN">0161-6420</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Ophthalmology : (Rochester, MN)</title><title level="j" type="abbreviated">Ophthalmology : (Rochester MN)</title><idno type="ISSN">0161-6420</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylic polymer</term><term>Biomaterial</term><term>Case study</term><term>Cataract</term><term>Complication</term><term>Diabetes mellitus</term><term>Elderly</term><term>Hydrophilic compound</term><term>Implantation</term><term>Intraocular</term><term>Intraocular lens</term><term>Opacification</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Diabète</term><term>Traitement</term><term>Cataracte</term><term>Implantation</term><term>Intraoculaire</term><term>Lentille intraoculaire</term><term>Complication</term><term>Opacification</term><term>Composé hydrophile</term><term>Acrylique dérivé polymère</term><term>Biomatériau</term><term>Etude cas</term><term>Personne âgée</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Diabète</term><term>Biomatériau</term><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To report clinicopathologic and ultrastructural features of two opacified single-piece hydrophilic acrylic intraocular lenses (lOLs) explanted from a diabetic patient. Design: Interventional case report with clinicopathologic correlation. Setting: A 64-year-old white female underwent phacoemulsification and implantation of a single-piece hydrophilic acrylic lens (SC60B-OUV; Medical Developmental Research, Inc., Clear Water, FL) in October 1998 in the left eye and in July 1999 in the right eye. The best-corrected visual acuity after surgery was 20/60 in the left eye and 20/50 in the right eye. The patient had a marked decrease in visual acuity in June 2000 as a result of a milky, white opalescence of both lenses. Intraocular lens explantation and exchange was performed in both eyes and the explanted lOLs were submitted to our center for detailed pathologic, histochemical, and ultrastructural evaluation. They were stained with alizarin red and the von Kossa method for calcium, and also underwent scanning electron microscopy and energy dispersive radiograph spectroscopy to ascertain the nature of the deposits leading to opacification. Main Outcome Measures: Documentation of calcium deposits confirmed by histochemical stains and surface analyses. Results: Opacification of the IOL was found to be the cause of decreased visual acuity. The opacification involved both the IOL optic and the haptics in the left eye and was confined to the IOL optic in the right eye. Histochemical and ultrastructural analyses revealed that the opacity was caused by deposition of calcium and phosphate within the lens optic and haptics. Conclusions: There are two features that distinguish this case from those reported earlier. This is the first clinicopathologic report of lens opacification that has involved completely the lens optic and the haptics. Second, these two explanted lOLs document the first bilateral case. This process of intraoptic and haptic opacification represents dystrophic calcification of unknown cause. Diabetic patients appear to be more severely and more often affected by lens opacification. Long-term follow-up of diabetic patients implanted with this IOL design should be maintained by surgeons and manufacturers.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0161-6420</s0></fA01><fA02 i1="01"><s0>OPHTDG</s0></fA02><fA03 i2="1"><s0>Ophthalmology : (Rochester MN)</s0></fA03><fA05><s2>109</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Hydrophilic acrylic intraocular lens optic and haptics Opacification in a diabetic patient bilateral case report and clinicopathologic correlation</s1></fA08><fA11 i1="01" i2="1"><s1>PANDEY (Suresh K.)</s1></fA11><fA11 i1="02" i2="1"><s1>WERNER (Liliana)</s1></fA11><fA11 i1="03" i2="1"><s1>APPLE (David J.)</s1></fA11><fA11 i1="04" i2="1"><s1>KASKALOGLU (Mahmut)</s1></fA11><fA14 i1="01"><s1>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina</s1><s2>Charleston, South Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Ege University</s1><s2>Alsancak Izmir</s2><s3>TUR</s3><sZ>4 aut.</sZ></fA14><fA20><s1>2042-2051</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18914</s2><s5>354000105167310230</s5></fA43><fA44><s0>0000</s0><s1>© 2003 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>27 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>03-0137391</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Ophthalmology : (Rochester, MN)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective: To report clinicopathologic and ultrastructural features of two opacified single-piece hydrophilic acrylic intraocular lenses (lOLs) explanted from a diabetic patient. Design: Interventional case report with clinicopathologic correlation. Setting: A 64-year-old white female underwent phacoemulsification and implantation of a single-piece hydrophilic acrylic lens (SC60B-OUV; Medical Developmental Research, Inc., Clear Water, FL) in October 1998 in the left eye and in July 1999 in the right eye. The best-corrected visual acuity after surgery was 20/60 in the left eye and 20/50 in the right eye. The patient had a marked decrease in visual acuity in June 2000 as a result of a milky, white opalescence of both lenses. Intraocular lens explantation and exchange was performed in both eyes and the explanted lOLs were submitted to our center for detailed pathologic, histochemical, and ultrastructural evaluation. They were stained with alizarin red and the von Kossa method for calcium, and also underwent scanning electron microscopy and energy dispersive radiograph spectroscopy to ascertain the nature of the deposits leading to opacification. Main Outcome Measures: Documentation of calcium deposits confirmed by histochemical stains and surface analyses. Results: Opacification of the IOL was found to be the cause of decreased visual acuity. The opacification involved both the IOL optic and the haptics in the left eye and was confined to the IOL optic in the right eye. Histochemical and ultrastructural analyses revealed that the opacity was caused by deposition of calcium and phosphate within the lens optic and haptics. Conclusions: There are two features that distinguish this case from those reported earlier. This is the first clinicopathologic report of lens opacification that has involved completely the lens optic and the haptics. Second, these two explanted lOLs document the first bilateral case. This process of intraoptic and haptic opacification represents dystrophic calcification of unknown cause. Diabetic patients appear to be more severely and more often affected by lens opacification. Long-term follow-up of diabetic patients implanted with this IOL design should be maintained by surgeons and manufacturers.</s0></fC01><fC02 i1="01" i2="X"><s0>002B21E01C</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Diabète</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Diabetes mellitus</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Diabetes</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Traitement</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Treatment</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tratamiento</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Cataracte</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Cataract</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Catarata</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Implantation</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Implantation</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Implantación</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Intraoculaire</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Intraocular</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Intraocular</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Lentille intraoculaire</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Intraocular lens</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Lente intraocular</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Complication</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Complication</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Complicación</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Opacification</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Opacification</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Opacificación</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Composé hydrophile</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Hydrophilic compound</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Compuesto hidrofilo</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Acrylique dérivé polymère</s0><s2>NK</s2><s5>11</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Acrylic polymer</s0><s2>NK</s2><s5>11</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Acrilico derivado polímero</s0><s2>NK</s2><s5>11</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Biomatériau</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Biomaterial</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Biomaterial</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Etude cas</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Case study</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Estudio caso</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Personne âgée</s0><s5>17</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Elderly</s0><s5>17</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Anciano</s0><s5>17</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Endocrinopathie</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Endocrinopathy</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Endocrinopatía</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Oeil pathologie</s0><s5>45</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Eye disease</s0><s5>45</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Ojo patología</s0><s5>45</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Cristallin pathologie</s0><s5>46</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Lens disease</s0><s5>46</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Cristalino patología</s0><s5>46</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Segment antérieur pathologie</s0><s2>NM</s2><s5>47</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Anterior segment disease</s0><s2>NM</s2><s5>47</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Segmento anterior patología</s0><s2>NM</s2><s5>47</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Chirurgie</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Surgery</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Cirugía</s0><s5>53</s5></fC07><fN21><s1>076</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Turquie</li><li>États-Unis</li></country><region><li>Caroline du Sud</li></region></list><tree><country name="États-Unis"><region name="Caroline du Sud"><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name></region><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J." last="Apple">David J. Apple</name><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name></country><country name="Turquie"><noRegion><name sortKey="Kaskaloglu, Mahmut" sort="Kaskaloglu, Mahmut" uniqKey="Kaskaloglu M" first="Mahmut" last="Kaskaloglu">Mahmut Kaskaloglu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F68 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000F68 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:03-0137391
|texte= Hydrophilic acrylic intraocular lens optic and haptics Opacification in a diabetic patient bilateral case report and clinicopathologic correlation
}}
| This area was generated with Dilib version V0.6.23. |  |