Multisensory plasticity in adulthood: cross-modal experience enhances neuronal excitability and exposes silent inputs
Identifieur interne : 002315 ( Ncbi/Merge ); précédent : 002314; suivant : 002316Multisensory plasticity in adulthood: cross-modal experience enhances neuronal excitability and exposes silent inputs
Auteurs : Liping Yu ; Benjamin A. Rowland ; Jinghong Xu ; Barry E. SteinSource :
- Journal of Neurophysiology [ 0022-3077 ] ; 2012.
Abstract
Multisensory superior colliculus neurons in cats were found to retain substantial plasticity to short-term, site-specific experience with cross-modal stimuli well into adulthood. Following cross-modal exposure trials, these neurons substantially increased their sensitivity to the cross-modal stimulus configuration as well as to its individual component stimuli. In many cases, the exposure experience also revealed a previously ineffective or “silent” input channel, rendering it overtly responsive. These experience-induced changes required relatively few exposure trials and could be retained for more than 1 h. However, their induction was generally restricted to experience with cross-modal stimuli. Only rarely were they induced by exposure to a modality-specific stimulus and were never induced by stimulating a previously ineffective input channel. This short-term plasticity likely provides substantial benefits to the organism in dealing with ongoing and sequential events that take place at a given location in space and may reflect the ability of multisensory superior colliculus neurons to rapidly alter their response properties to accommodate to changes in environmental challenges and event probabilities.
Url:
DOI: 10.1152/jn.00739.2012
PubMed: 23114212
PubMed Central: 3545460
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PMC:3545460Le document en format XML
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<author><name sortKey="Yu, Liping" sort="Yu, Liping" uniqKey="Yu L" first="Liping" last="Yu">Liping Yu</name>
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<author><name sortKey="Rowland, Benjamin A" sort="Rowland, Benjamin A" uniqKey="Rowland B" first="Benjamin A." last="Rowland">Benjamin A. Rowland</name>
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<author><name sortKey="Xu, Jinghong" sort="Xu, Jinghong" uniqKey="Xu J" first="Jinghong" last="Xu">Jinghong Xu</name>
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<series><title level="j">Journal of Neurophysiology</title>
<idno type="ISSN">0022-3077</idno>
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<front><div type="abstract" xml:lang="en"><p>Multisensory superior colliculus neurons in cats were found to retain substantial plasticity to short-term, site-specific experience with cross-modal stimuli well into adulthood. Following cross-modal exposure trials, these neurons substantially increased their sensitivity to the cross-modal stimulus configuration as well as to its individual component stimuli. In many cases, the exposure experience also revealed a previously ineffective or “silent” input channel, rendering it overtly responsive. These experience-induced changes required relatively few exposure trials and could be retained for more than 1 h. However, their induction was generally restricted to experience with cross-modal stimuli. Only rarely were they induced by exposure to a modality-specific stimulus and were never induced by stimulating a previously ineffective input channel. This short-term plasticity likely provides substantial benefits to the organism in dealing with ongoing and sequential events that take place at a given location in space and may reflect the ability of multisensory superior colliculus neurons to rapidly alter their response properties to accommodate to changes in environmental challenges and event probabilities.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurophysiol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Neurophysiol</journal-id>
<journal-id journal-id-type="hwp">jn</journal-id>
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<issn pub-type="ppub">0022-3077</issn>
<issn pub-type="epub">1522-1598</issn>
<publisher><publisher-name>American Physiological Society</publisher-name>
<publisher-loc>Bethesda, MD</publisher-loc>
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<article-id pub-id-type="publisher-id">JN-00739-2012</article-id>
<article-id pub-id-type="doi">10.1152/jn.00739.2012</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Multisensory plasticity in adulthood: cross-modal experience enhances neuronal excitability and exposes silent inputs</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Liping</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Rowland</surname>
<given-names>Benjamin A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname>
<given-names>Jinghong</given-names>
</name>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Stein</surname>
<given-names>Barry E.</given-names>
</name>
</contrib>
<aff>Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina</aff>
</contrib-group>
<author-notes><corresp>Address for reprint requests and other correspondence: B. E. Stein, <addr-line>Dept. of Neurobiology and Anatomy, Wake Forest Univ. School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1010</addr-line>
(e-mail: <email>bestein@wakehealth.edu</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>1</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>31</day>
<month>10</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>1</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>109</volume>
<issue>2</issue>
<fpage>464</fpage>
<lpage>474</lpage>
<history><date date-type="received"><day>23</day>
<month>8</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>25</day>
<month>10</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 the American Physiological Society</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z9k00213000464.pdf"></self-uri>
<abstract><p>Multisensory superior colliculus neurons in cats were found to retain substantial plasticity to short-term, site-specific experience with cross-modal stimuli well into adulthood. Following cross-modal exposure trials, these neurons substantially increased their sensitivity to the cross-modal stimulus configuration as well as to its individual component stimuli. In many cases, the exposure experience also revealed a previously ineffective or “silent” input channel, rendering it overtly responsive. These experience-induced changes required relatively few exposure trials and could be retained for more than 1 h. However, their induction was generally restricted to experience with cross-modal stimuli. Only rarely were they induced by exposure to a modality-specific stimulus and were never induced by stimulating a previously ineffective input channel. This short-term plasticity likely provides substantial benefits to the organism in dealing with ongoing and sequential events that take place at a given location in space and may reflect the ability of multisensory superior colliculus neurons to rapidly alter their response properties to accommodate to changes in environmental challenges and event probabilities.</p>
</abstract>
<kwd-group><kwd>visual</kwd>
<kwd>auditory</kwd>
<kwd>multisensory integration</kwd>
<kwd>plasticity</kwd>
<kwd>sensory exposure</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source>
<award-id rid="CS100">EY016716</award-id>
<award-id rid="CS100">NS036916</award-id>
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<tree><noCountry><name sortKey="Rowland, Benjamin A" sort="Rowland, Benjamin A" uniqKey="Rowland B" first="Benjamin A." last="Rowland">Benjamin A. Rowland</name>
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<name sortKey="Xu, Jinghong" sort="Xu, Jinghong" uniqKey="Xu J" first="Jinghong" last="Xu">Jinghong Xu</name>
<name sortKey="Yu, Liping" sort="Yu, Liping" uniqKey="Yu L" first="Liping" last="Yu">Liping Yu</name>
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