Magnetic resonance imaging of the anteroposterior position and thickness of the aging, accommodating, phakic, and pseudophakic ciliary muscle
Identifieur interne : 001439 ( Ncbi/Merge ); précédent : 001438; suivant : 001440Magnetic resonance imaging of the anteroposterior position and thickness of the aging, accommodating, phakic, and pseudophakic ciliary muscle
Auteurs : Susan A. Strenk ; Lawrence M. Strenk ; Suqin GuoSource :
- Journal of cataract and refractive surgery [ 0886-3350 ] ; 2010.
Abstract
To quantify accommodative and age-related changes in the anteroposterior position and thickness of the ciliary muscle in phakic and pseudophakic eyes.
Department of Surgery/Bioengineering, UMDNJ–Robert Wood Johnson Medical School, Piscataway; Institute of Ophthalmology and Visual Science UMDNJ–New Jersey Medical School, Newark, New Jersey; MRI Research, Inc., Middleburg Heights, Ohio, USA.
Magnetic resonance images were taken of phakic and pseudophakic eyes.
The cohort comprised 32 phakic volunteers and 8 volunteers with a monocular intraocular lens (IOL) aged 22 to 91 years. No anteroposterior accommodative movement of the ciliary muscle apex occurred in either group. The muscle moved closer to the cornea with advancing age in phakic eyes; IOL implantation returned the muscle to a youthful position. An age-dependent increase in ciliary muscle anteroposterior thickness occurred that was not mitigated by IOL implantation. Muscle thickness increased with accommodation only in phakic eyes.
Presbyopia-correction strategies cannot rely on accommodative anterior movement of the ciliary muscle. Forces on the uvea by crystalline lens–pupillary margin contact may increase with accommodation and lens growth, producing accommodative and age-dependent increases in muscle thickness and significant age-dependent anterior muscle displacement. Intraocular lens implantation removed these forces, allowing choroidal elasticity to restore the muscle to a youthful position; however, the increase in thickness was permanent and likely due to an age-dependent increase in connective tissue. This supports the geometric theory of presbyopia development and that the mechanical forces in human accommodation and presbyopia are very different from those in the rhesus monkey model.
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DOI: 10.1016/j.jcrs.2009.08.029
PubMed: 20152603
PubMed Central: 2826892
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8604171</journal-id><journal-id journal-id-type="pubmed-jr-id">5175</journal-id><journal-id journal-id-type="nlm-ta">J Cataract Refract Surg</journal-id><journal-title>Journal of cataract and refractive surgery</journal-title><issn pub-type="ppub">0886-3350</issn><issn pub-type="epub">1873-4502</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20152603</article-id><article-id pub-id-type="pmc">2826892</article-id><article-id pub-id-type="doi">10.1016/j.jcrs.2009.08.029</article-id><article-id pub-id-type="manuscript">NIHMS177037</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Magnetic resonance imaging of the anteroposterior position and thickness of the aging, accommodating, phakic, and pseudophakic ciliary muscle</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Strenk</surname><given-names>Susan A.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Strenk</surname><given-names>Lawrence M.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Suqin</given-names></name><degrees>MD</degrees></contrib><aff id="A1">Department of Surgery/Bioengineering (S.A. Strenk), UMDNJ–Robert Wood Johnson Medical School, Piscataway, and the Institute of Ophthalmology and Visual Science (Guo), UMDNJ–New Jersey Medical School, Newark, New Jersey; MRI Research, Inc. (S.A. Strenk, L.M. Strenk), Middleburg Heights, Ohio, USA.</aff></contrib-group><author-notes><corresp id="CR1">Corresponding author: S.A. Strenk, PhD, MRI Research, Inc., Middleburg Heights, Ohio, USA. <email>sstrenk@wowway.com</email>.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2011</year></pub-date><volume>36</volume><issue>2</issue><fpage>235</fpage><lpage>241</lpage><permissions><copyright-statement>© 2009 American Society of Cataract and Refractive Surgery and European Society of Cataract and Refractive Surgeons. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2009</copyright-year></permissions><abstract><sec id="S1"><title>PURPOSE</title><p id="P1">To quantify accommodative and age-related changes in the anteroposterior position and thickness of the ciliary muscle in phakic and pseudophakic eyes.</p></sec><sec id="S2"><title>SETTING</title><p id="P2">Department of Surgery/Bioengineering, UMDNJ–Robert Wood Johnson Medical School, Piscataway; Institute of Ophthalmology and Visual Science UMDNJ–New Jersey Medical School, Newark, New Jersey; MRI Research, Inc., Middleburg Heights, Ohio, USA.</p></sec><sec sec-type="methods" id="S3"><title>METHODS</title><p id="P3">Magnetic resonance images were taken of phakic and pseudophakic eyes.</p></sec><sec id="S4"><title>RESULTS</title><p id="P4">The cohort comprised 32 phakic volunteers and 8 volunteers with a monocular intraocular lens (IOL) aged 22 to 91 years. No anteroposterior accommodative movement of the ciliary muscle apex occurred in either group. The muscle moved closer to the cornea with advancing age in phakic eyes; IOL implantation returned the muscle to a youthful position. An age-dependent increase in ciliary muscle anteroposterior thickness occurred that was not mitigated by IOL implantation. Muscle thickness increased with accommodation only in phakic eyes.</p></sec><sec id="S5"><title>CONCLUSIONS</title><p id="P5">Presbyopia-correction strategies cannot rely on accommodative anterior movement of the ciliary muscle. Forces on the uvea by crystalline lens–pupillary margin contact may increase with accommodation and lens growth, producing accommodative and age-dependent increases in muscle thickness and significant age-dependent anterior muscle displacement. Intraocular lens implantation removed these forces, allowing choroidal elasticity to restore the muscle to a youthful position; however, the increase in thickness was permanent and likely due to an age-dependent increase in connective tissue. This supports the geometric theory of presbyopia development and that the mechanical forces in human accommodation and presbyopia are very different from those in the rhesus monkey model.</p></sec></abstract><contract-num rid="EY1">R43 EY015655-01
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||EY</contract-num><contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Guo, Suqin" sort="Guo, Suqin" uniqKey="Guo S" first="Suqin" last="Guo">Suqin Guo</name><name sortKey="Strenk, Lawrence M" sort="Strenk, Lawrence M" uniqKey="Strenk L" first="Lawrence M." last="Strenk">Lawrence M. Strenk</name><name sortKey="Strenk, Susan A" sort="Strenk, Susan A" uniqKey="Strenk S" first="Susan A." last="Strenk">Susan A. Strenk</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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