Bioactive interpenetrating polymer network hydrogels that support corneal epithelial wound healing
Identifieur interne : 000E44 ( Ncbi/Merge ); précédent : 000E43; suivant : 000E45Bioactive interpenetrating polymer network hydrogels that support corneal epithelial wound healing
Auteurs : David Myung [États-Unis] ; Nabeel Farooqui [États-Unis] ; Luo Luo Zheng [États-Unis] ; Wongun Koh [Corée du Sud] ; Jaan Noolandi [États-Unis] ; Jennifer R. Cochran [États-Unis] ; Curtis W. Frank [États-Unis] ; Christopher N. Ta [États-Unis]Source :
- Journal of biomedical materials research. Part A [ 1549-3296 ] ; 2009.
Abstract
We describe the development and characterization of collagen-coupled poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) interpenetrating polymer network hydrogels. Quantitative amino acid analysis and FITC-labeling of collagen were used to determine the amount and distribution of collagen on the surface of the hydrogels. The bioactivity of the coupled collagen was detected by a conformation-specific antibody and was found to vary with the concentration of collagen reacted to the photochemically functionalized hydrogel surfaces. A wound healing assay based on an organ culture model demonstrated that this bioactive surface supports epithelial wound closure over the hydrogel but at a decreased rate relative to sham wounds. Implantation of the hydrogel into the corneas of live rabbits demonstrated that epithelial cell migration is supported by the material, although the rate of migration and morphology of the epithelium were not normal. The results from the study will be used as a guide toward the optimization of bioactive hydrogels with promise in corneal implant applications such as a corneal onlay and an artificial cornea.
Url:
DOI: 10.1002/jbm.a.32056
PubMed: 18481785
PubMed Central: 2856598
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PMC:2856598Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">We describe the development and characterization of collagen-coupled poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) interpenetrating polymer network hydrogels. Quantitative amino acid analysis and FITC-labeling of collagen were used to determine the amount and distribution of collagen on the surface of the hydrogels. The bioactivity of the coupled collagen was detected by a conformation-specific antibody and was found to vary with the concentration of collagen reacted to the photochemically functionalized hydrogel surfaces. A wound healing assay based on an organ culture model demonstrated that this bioactive surface supports epithelial wound closure over the hydrogel but at a decreased rate relative to sham wounds. Implantation of the hydrogel into the corneas of live rabbits demonstrated that epithelial cell migration is supported by the material, although the rate of migration and morphology of the epithelium were not normal. The results from the study will be used as a guide toward the optimization of bioactive hydrogels with promise in corneal implant applications such as a corneal onlay and an artificial cornea.</p>
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<journal-id journal-id-type="pubmed-jr-id">32207</journal-id>
<journal-id journal-id-type="nlm-ta">J Biomed Mater Res A</journal-id>
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<title-group><article-title>Bioactive interpenetrating polymer network hydrogels that support corneal epithelial wound healing</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Myung</surname>
<given-names>David</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="A2" ref-type="aff">2</xref>
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<contrib contrib-type="author"><name><surname>Farooqui</surname>
<given-names>Nabeel</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Luo Luo</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Koh</surname>
<given-names>Wongun</given-names>
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<xref rid="A3" ref-type="aff">3</xref>
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<given-names>Jaan</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="A2" ref-type="aff">2</xref>
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<contrib contrib-type="author"><name><surname>Cochran</surname>
<given-names>Jennifer R.</given-names>
</name>
<xref rid="A4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frank</surname>
<given-names>Curtis W.</given-names>
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<xref rid="A2" ref-type="aff">2</xref>
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<contrib contrib-type="author"><name><surname>Ta</surname>
<given-names>Christopher N.</given-names>
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<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">#</xref>
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<aff id="A1"><label>1</label>
Department of Ophthalmology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305–5080</aff>
<aff id="A2"><label>2</label>
Department of Chemical Engineering, Stanford University, 381 North-South Mall, Stauffer III, Stanford, CA 94305</aff>
<aff id="A3"><label>3</label>
Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong, Seodaemoon-ku, Seoul 120–749, South Korea</aff>
<aff id="A4"><label>4</label>
Department of Bioengineering, Stanford University, 318 Campus Drive, Clark Center, Stanford, CA 94305</aff>
<author-notes><corresp id="FN1"><label>#</label>
Author to whom correspondence should be addressed. Department of Ophthalmology, Stanford University, 900 Blake Wilbur Drive, W3036, Stanford, CA 94304–5353. <email>cta@stanford.edu</email>
, Phone: (650) 498–4791, Fax: (650) 498–4222</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>19</day>
<month>4</month>
<year>2010</year>
</pub-date>
<volume>90</volume>
<issue>1</issue>
<fpage>70</fpage>
<lpage>81</lpage>
<abstract><p id="P1">We describe the development and characterization of collagen-coupled poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) interpenetrating polymer network hydrogels. Quantitative amino acid analysis and FITC-labeling of collagen were used to determine the amount and distribution of collagen on the surface of the hydrogels. The bioactivity of the coupled collagen was detected by a conformation-specific antibody and was found to vary with the concentration of collagen reacted to the photochemically functionalized hydrogel surfaces. A wound healing assay based on an organ culture model demonstrated that this bioactive surface supports epithelial wound closure over the hydrogel but at a decreased rate relative to sham wounds. Implantation of the hydrogel into the corneas of live rabbits demonstrated that epithelial cell migration is supported by the material, although the rate of migration and morphology of the epithelium were not normal. The results from the study will be used as a guide toward the optimization of bioactive hydrogels with promise in corneal implant applications such as a corneal onlay and an artificial cornea.</p>
</abstract>
<contract-num rid="EY1">R01 EY016987-02
||EY</contract-num>
<contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor>
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