OPTICAL PRINCIPLES, BIOMECHANICS, AND INITIAL CLINICAL PERFORMANCE OF A DUAL-OPTIC ACCOMMODATING INTRAOCULAR LENS (AN AMERICAN OPHTHALMOLOGICAL SOCIETY THESIS)
Identifieur interne : 000B52 ( Ncbi/Merge ); précédent : 000B51; suivant : 000B53OPTICAL PRINCIPLES, BIOMECHANICS, AND INITIAL CLINICAL PERFORMANCE OF A DUAL-OPTIC ACCOMMODATING INTRAOCULAR LENS (AN AMERICAN OPHTHALMOLOGICAL SOCIETY THESIS)
Auteurs : Stephen D. McleodSource :
- Transactions of the American Ophthalmological Society [ 0065-9533 ] ; 2006.
Abstract
To design and develop an accommodating intraocular lens (IOL) for endocapsular fixation with extended accommodative range that can be adapted to current standard extracapsular phacoemulsification technique.
Ray tracing analysis and lens design; finite element modeling of biomechanical properties; cadaver eye implantation; initial clinical evaluation.
Ray tracing analysis indicated that a dual-optic design with a high plus-power front optic coupled to an optically compensatory minus posterior optic produced greater change in conjugation power of the eye compared to that produced by axial movement of a single-optic IOL, and that magnification effects were unlikely to account for improved near vision. Finite element modeling indicated that the two optics can be linked by spring-loaded haptics that allow anterior and posterior axial displacement of the front optic in response to changes in ciliary body tone and capsular tension. A dual-optic single-piece foldable silicone lens was constructed based on these principles. Subsequent initial clinical evaluation in 24 human eyes after phacoemulsification for cataract indicated mean 3.22 diopters of accommodation (range, 1 to 5 D) based on defocus curve measurement. Accommodative amplitude evaluation at 1- and 6-month follow-up in all eyes indicated that the accommodative range was maintained and that the lens was well tolerated.
A dual-optic design increases the accommodative effect of axial optic displacement, with minimal magnification effect. Initial clinical trials suggest that IOLs designed on this principle might provide true pseudophakic accommodation following cataract extraction and lens implantation.
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PubMed: 17471355
PubMed Central: 1809902
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">OPTICAL PRINCIPLES, BIOMECHANICS, AND INITIAL CLINICAL PERFORMANCE OF A DUAL-OPTIC ACCOMMODATING INTRAOCULAR LENS (AN AMERICAN OPHTHALMOLOGICAL SOCIETY THESIS)</title><author><name sortKey="Mcleod, Stephen D" sort="Mcleod, Stephen D" uniqKey="Mcleod S" first="Stephen D." last="Mcleod">Stephen D. Mcleod</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17471355</idno><idno type="pmc">1809902</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809902</idno><idno type="RBID">PMC:1809902</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">001579</idno><idno type="wicri:Area/Pmc/Curation">001579</idno><idno type="wicri:Area/Pmc/Checkpoint">002533</idno><idno type="wicri:Area/Ncbi/Merge">000B52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">OPTICAL PRINCIPLES, BIOMECHANICS, AND INITIAL CLINICAL PERFORMANCE OF A DUAL-OPTIC ACCOMMODATING INTRAOCULAR LENS (AN AMERICAN OPHTHALMOLOGICAL SOCIETY THESIS)</title><author><name sortKey="Mcleod, Stephen D" sort="Mcleod, Stephen D" uniqKey="Mcleod S" first="Stephen D." last="Mcleod">Stephen D. Mcleod</name></author></analytic><series><title level="j">Transactions of the American Ophthalmological Society</title><idno type="ISSN">0065-9533</idno><idno type="eISSN">1545-6110</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To design and develop an accommodating intraocular lens (IOL) for endocapsular fixation with extended accommodative range that can be adapted to current standard extracapsular phacoemulsification technique.</p></sec><sec sec-type="methods"><title>Methods</title><p>Ray tracing analysis and lens design; finite element modeling of biomechanical properties; cadaver eye implantation; initial clinical evaluation.</p></sec><sec><title>Results</title><p>Ray tracing analysis indicated that a dual-optic design with a high plus-power front optic coupled to an optically compensatory minus posterior optic produced greater change in conjugation power of the eye compared to that produced by axial movement of a single-optic IOL, and that magnification effects were unlikely to account for improved near vision. Finite element modeling indicated that the two optics can be linked by spring-loaded haptics that allow anterior and posterior axial displacement of the front optic in response to changes in ciliary body tone and capsular tension. A dual-optic single-piece foldable silicone lens was constructed based on these principles. Subsequent initial clinical evaluation in 24 human eyes after phacoemulsification for cataract indicated mean 3.22 diopters of accommodation (range, 1 to 5 D) based on defocus curve measurement. Accommodative amplitude evaluation at 1- and 6-month follow-up in all eyes indicated that the accommodative range was maintained and that the lens was well tolerated.</p></sec><sec><title>Conclusions</title><p>A dual-optic design increases the accommodative effect of axial optic displacement, with minimal magnification effect. Initial clinical trials suggest that IOLs designed on this principle might provide true pseudophakic accommodation following cataract extraction and lens implantation.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Trans Am Ophthalmol Soc</journal-id><journal-title>Transactions of the American Ophthalmological Society</journal-title><issn pub-type="ppub">0065-9533</issn><issn pub-type="epub">1545-6110</issn><publisher><publisher-name>The American Ophthalmological Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17471355</article-id><article-id pub-id-type="pmc">1809902</article-id><article-id pub-id-type="publisher-id">1545-6110_v104_p437</article-id><article-categories><subj-group subj-group-type="heading"><subject>2006 Theses</subject></subj-group></article-categories><title-group><article-title>OPTICAL PRINCIPLES, BIOMECHANICS, AND INITIAL CLINICAL PERFORMANCE OF A DUAL-OPTIC ACCOMMODATING INTRAOCULAR LENS (AN AMERICAN OPHTHALMOLOGICAL SOCIETY THESIS)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>McLeod</surname><given-names>Stephen D.</given-names></name><degrees>MD</degrees></contrib><aff id="af1-1545-6110_v104_p437">From the Department of Ophthalmology, University of California San Francisco, San Francisco, California. Dr McLeod has a financial interest in Visiogen Inc and in the device described herein. He owns founding stock in Visiogen Inc and has received research support and travel reimbursement from Visiogen Inc</aff></contrib-group><pub-date pub-type="ppub"><month>12</month><year>2006</year></pub-date><volume>104</volume><fpage>437</fpage><lpage>452</lpage><copyright-statement>©American Ophthalmological Society 2006</copyright-statement><copyright-year>2006</copyright-year><abstract><sec><title>Purpose</title><p>To design and develop an accommodating intraocular lens (IOL) for endocapsular fixation with extended accommodative range that can be adapted to current standard extracapsular phacoemulsification technique.</p></sec><sec sec-type="methods"><title>Methods</title><p>Ray tracing analysis and lens design; finite element modeling of biomechanical properties; cadaver eye implantation; initial clinical evaluation.</p></sec><sec><title>Results</title><p>Ray tracing analysis indicated that a dual-optic design with a high plus-power front optic coupled to an optically compensatory minus posterior optic produced greater change in conjugation power of the eye compared to that produced by axial movement of a single-optic IOL, and that magnification effects were unlikely to account for improved near vision. Finite element modeling indicated that the two optics can be linked by spring-loaded haptics that allow anterior and posterior axial displacement of the front optic in response to changes in ciliary body tone and capsular tension. A dual-optic single-piece foldable silicone lens was constructed based on these principles. Subsequent initial clinical evaluation in 24 human eyes after phacoemulsification for cataract indicated mean 3.22 diopters of accommodation (range, 1 to 5 D) based on defocus curve measurement. Accommodative amplitude evaluation at 1- and 6-month follow-up in all eyes indicated that the accommodative range was maintained and that the lens was well tolerated.</p></sec><sec><title>Conclusions</title><p>A dual-optic design increases the accommodative effect of axial optic displacement, with minimal magnification effect. Initial clinical trials suggest that IOLs designed on this principle might provide true pseudophakic accommodation following cataract extraction and lens implantation.</p></sec></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Mcleod, Stephen D" sort="Mcleod, Stephen D" uniqKey="Mcleod S" first="Stephen D." last="Mcleod">Stephen D. Mcleod</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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