Visual Improvement in High Myopic Amblyopic Adult Eyes following Phakic Anterior Chamber Intraocular Lens Implantation
Identifieur interne : 000963 ( Ncbi/Merge ); précédent : 000962; suivant : 000964Visual Improvement in High Myopic Amblyopic Adult Eyes following Phakic Anterior Chamber Intraocular Lens Implantation
Auteurs : Sang Won Kwon [Corée du Sud] ; Hyun Seung Moon [Corée du Sud] ; Kyung Hwan Shyn [Corée du Sud]Source :
- Korean Journal of Ophthalmology : KJO [ 1011-8942 ] ; 2006.
Abstract
To evaluate the efficacy and safety of angle-supported phakic anterior chamber intraocular lenses in amblyopic adult eyes with very high myopia.
We evaluated 12 eyes in nine patients with very high myopic amblyopia who received angle-supported phakic intraocular lenses (Phakic 6H®) and followed them for more than six months. Uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), and complications were evaluated. A satisfaction score was rated by patients using a 5-point (1~5) numeric scale.
The mean age of patients was 37.3±9.4 years, ranging from 29 to 59 years old. The preoperative mean refraction (spherical equivalent, SE) was -20.10±5.41 diopters (D). The postoperative mean refraction (SE) was -1.75±0.76 D at six months. The postoperative BCVA improved an average 3.92±1.24 lines over preoperative values, and mean endothelial cell loss was 8.9% at six months. Development of cataracts, glaucoma, and pupil abnormalities were not demonstrated in any case during the study. The patients were all very satisfied, as the average satisfaction score was 4.3.
This study indicates that angle-supported phakic anterior chamber intraocular lens implantation may be an effective surgical alternative for the correction of amblyopic adult eyes with very high myopia. However, long-term evaluation is necessary to assess possible complications and long-term safety.
Url:
DOI: 10.3341/kjo.2006.20.2.87
PubMed: 16892643
PubMed Central: 2908833
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Visual Improvement in High Myopic Amblyopic Adult Eyes following Phakic Anterior Chamber Intraocular Lens Implantation</title><author><name sortKey="Kwon, Sang Won" sort="Kwon, Sang Won" uniqKey="Kwon S" first="Sang Won" last="Kwon">Sang Won Kwon</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Moon, Hyun Seung" sort="Moon, Hyun Seung" uniqKey="Moon H" first="Hyun Seung" last="Moon">Hyun Seung Moon</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Shyn, Kyung Hwan" sort="Shyn, Kyung Hwan" uniqKey="Shyn K" first="Kyung Hwan" last="Shyn">Kyung Hwan Shyn</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16892643</idno><idno type="pmc">2908833</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908833</idno><idno type="RBID">PMC:2908833</idno><idno type="doi">10.3341/kjo.2006.20.2.87</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">002100</idno><idno type="wicri:Area/Pmc/Curation">002100</idno><idno type="wicri:Area/Pmc/Checkpoint">002500</idno><idno type="wicri:Area/Ncbi/Merge">000963</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Visual Improvement in High Myopic Amblyopic Adult Eyes following Phakic Anterior Chamber Intraocular Lens Implantation</title><author><name sortKey="Kwon, Sang Won" sort="Kwon, Sang Won" uniqKey="Kwon S" first="Sang Won" last="Kwon">Sang Won Kwon</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Moon, Hyun Seung" sort="Moon, Hyun Seung" uniqKey="Moon H" first="Hyun Seung" last="Moon">Hyun Seung Moon</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Shyn, Kyung Hwan" sort="Shyn, Kyung Hwan" uniqKey="Shyn K" first="Kyung Hwan" last="Shyn">Kyung Hwan Shyn</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author></analytic><series><title level="j">Korean Journal of Ophthalmology : KJO</title><idno type="ISSN">1011-8942</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate the efficacy and safety of angle-supported phakic anterior chamber intraocular lenses in amblyopic adult eyes with very high myopia.</p></sec><sec><title>Methods</title><p>We evaluated 12 eyes in nine patients with very high myopic amblyopia who received angle-supported phakic intraocular lenses (Phakic 6H®) and followed them for more than six months. Uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), and complications were evaluated. A satisfaction score was rated by patients using a 5-point (1~5) numeric scale.</p></sec><sec><title>Results</title><p>The mean age of patients was 37.3±9.4 years, ranging from 29 to 59 years old. The preoperative mean refraction (spherical equivalent, SE) was -20.10±5.41 diopters (D). The postoperative mean refraction (SE) was -1.75±0.76 D at six months. The postoperative BCVA improved an average 3.92±1.24 lines over preoperative values, and mean endothelial cell loss was 8.9% at six months. Development of cataracts, glaucoma, and pupil abnormalities were not demonstrated in any case during the study. The patients were all very satisfied, as the average satisfaction score was 4.3.</p></sec><sec><title>Conclusions</title><p>This study indicates that angle-supported phakic anterior chamber intraocular lens implantation may be an effective surgical alternative for the correction of amblyopic adult eyes with very high myopia. However, long-term evaluation is necessary to assess possible complications and long-term safety.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arne, Jl" uniqKey="Arne J">JL Arne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colin, J" uniqKey="Colin J">J Colin</name></author><author><name sortKey="Robinet, A" uniqKey="Robinet A">A Robinet</name></author><author><name sortKey="Cochener, B" uniqKey="Cochener B">B Cochener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pineda Fernandez, A" uniqKey="Pineda Fernandez A">A Pineda-Fernandez</name></author><author><name sortKey="Jaramillo, J" uniqKey="Jaramillo J">J Jaramillo</name></author><author><name sortKey="Vargas, J" uniqKey="Vargas J">J Vargas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menezo, Jl" uniqKey="Menezo J">JL Menezo</name></author><author><name sortKey="Peris Martinez, C" uniqKey="Peris Martinez C">C Peris-Martinez</name></author><author><name sortKey="Cisneros, Al" uniqKey="Cisneros A">AL Cisneros</name></author><author><name sortKey="Martinez Costa, R" uniqKey="Martinez Costa R">R Martinez-Costa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyle, Wa" uniqKey="Lyle W">WA Lyle</name></author><author><name sortKey="Jin, Gj" uniqKey="Jin G">GJ Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sher, Na" uniqKey="Sher N">NA Sher</name></author><author><name sortKey="Barak, M" uniqKey="Barak M">M Barak</name></author><author><name sortKey="Daya, S" uniqKey="Daya S">S Daya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huber, C" uniqKey="Huber C">C Huber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pallikaris, Ig" uniqKey="Pallikaris I">IG Pallikaris</name></author><author><name sortKey="Papatzanak, Me" uniqKey="Papatzanak M">ME Papatzanak</name></author><author><name sortKey="Stathi, Ez" uniqKey="Stathi E">EZ Stathi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geggel, Hs" uniqKey="Geggel H">HS Geggel</name></author><author><name sortKey="Talley, Ar" uniqKey="Talley A">AR Talley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holladay, Jt" uniqKey="Holladay J">JT Holladay</name></author><author><name sortKey="Dudeja, Kr" uniqKey="Dudeja K">KR Dudeja</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oshika, T" uniqKey="Oshika T">T Oshika</name></author><author><name sortKey="Klyce, Sd" uniqKey="Klyce S">SD Klyce</name></author><author><name sortKey="Applegate, Ra" uniqKey="Applegate R">RA Applegate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pesando, Pm" uniqKey="Pesando P">PM Pesando</name></author><author><name sortKey="Ghiringhello, Mp" uniqKey="Ghiringhello M">MP Ghiringhello</name></author><author><name sortKey="Tagliavacche, P" uniqKey="Tagliavacche P">P Tagliavacche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allemann, N" uniqKey="Allemann N">N Allemann</name></author><author><name sortKey="Chamon, W" uniqKey="Chamon W">W Chamon</name></author><author><name sortKey="Tanaka, Hm" uniqKey="Tanaka H">HM Tanaka</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Rj" uniqKey="Smith R">RJ Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waring, Go" uniqKey="Waring G">GO Waring</name></author><author><name sortKey="Lynn, Mj" uniqKey="Lynn M">MJ Lynn</name></author><author><name sortKey="Nizam, A" uniqKey="Nizam A">A Nizam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buratto, L" uniqKey="Buratto L">L Buratto</name></author><author><name sortKey="Ferrari, M" uniqKey="Ferrari M">M Ferrari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutt, S" uniqKey="Dutt S">S Dutt</name></author><author><name sortKey="Steinert, Rf" uniqKey="Steinert R">RF Steinert</name></author><author><name sortKey="Raizman, Mb" uniqKey="Raizman M">MB Raizman</name></author><author><name sortKey="Puliafito, Ca" uniqKey="Puliafito C">CA Puliafito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assetto, V" uniqKey="Assetto V">V Assetto</name></author><author><name sortKey="Benedetti, S" uniqKey="Benedetti S">S Benedetti</name></author><author><name sortKey="Pesando, P" uniqKey="Pesando P">P Pesando</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Santonja, Jj" uniqKey="Perez Santonja J">JJ Perez-Santonja</name></author><author><name sortKey="Iradier, Mt" uniqKey="Iradier M">MT Iradier</name></author><author><name sortKey="Benitez Del Castillo, Jm" uniqKey="Benitez Del Castillo J">JM Benitez del Castillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alio, Jl" uniqKey="Alio J">JL Alio</name></author><author><name sortKey="De La Hoz, F" uniqKey="De La Hoz F">F de la Hoz</name></author><author><name sortKey="Perez Santonja, Jj" uniqKey="Perez Santonja J">JJ Perez-Santonja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaldivar, R" uniqKey="Zaldivar R">R Zaldivar</name></author><author><name sortKey="Davidorff, Jm" uniqKey="Davidorff J">JM Davidorff</name></author><author><name sortKey="Oscherow, S" uniqKey="Oscherow S">S Oscherow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baikoff, G" uniqKey="Baikoff G">G Baikoff</name></author><author><name sortKey="Arne, Jl" uniqKey="Arne J">JL Arne</name></author><author><name sortKey="Bokobza, Y" uniqKey="Bokobza Y">Y Bokobza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jean, La" uniqKey="Jean L">LA Jean</name></author><author><name sortKey="Laurence, Cl" uniqKey="Laurence C">CL Laurence</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lackner, B" uniqKey="Lackner B">B Lackner</name></author><author><name sortKey="Pieh, S" uniqKey="Pieh S">S Pieh</name></author><author><name sortKey="Schmidinger, G" uniqKey="Schmidinger G">G Schmidinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campos, E" uniqKey="Campos E">E Campos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Applegate, Ra" uniqKey="Applegate R">RA Applegate</name></author><author><name sortKey="Howland, Hc" uniqKey="Howland H">HC Howland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Mallah, Mk" uniqKey="El Mallah M">MK El Mallah</name></author><author><name sortKey="Chakravarthy, U" uniqKey="Chakravarthy U">U Chakravarthy</name></author><author><name sortKey="Hart, Pm" uniqKey="Hart P">PM Hart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wick, B" uniqKey="Wick B">B Wick</name></author><author><name sortKey="Wingard, M" uniqKey="Wingard M">M Wingard</name></author><author><name sortKey="Cotter, S" uniqKey="Cotter S">S Cotter</name></author><author><name sortKey="Scheiman, M" uniqKey="Scheiman M">M Scheiman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simmers, Aj" uniqKey="Simmers A">AJ Simmers</name></author><author><name sortKey="Gray, Ls" uniqKey="Gray L">LS Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakatani, K" uniqKey="Sakatani K">K Sakatani</name></author><author><name sortKey="Jabbur, Ns" uniqKey="Jabbur N">NS Jabbur</name></author><author><name sortKey="O Brien, Tp" uniqKey="O Brien T">TP O'Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barequet, Is" uniqKey="Barequet I">IS Barequet</name></author><author><name sortKey="Wygnanski Jaffe, T" uniqKey="Wygnanski Jaffe T">T Wygnanski-Jaffe</name></author><author><name sortKey="Hirsh, A" uniqKey="Hirsh A">A Hirsh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Korean J Ophthalmol</journal-id><journal-id journal-id-type="publisher-id">KJO</journal-id><journal-title-group><journal-title>Korean Journal of Ophthalmology : KJO</journal-title></journal-title-group><issn pub-type="ppub">1011-8942</issn><publisher><publisher-name>The Korean Ophthalmological Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16892643</article-id><article-id pub-id-type="pmc">2908833</article-id><article-id pub-id-type="doi">10.3341/kjo.2006.20.2.87</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Visual Improvement in High Myopic Amblyopic Adult Eyes following Phakic Anterior Chamber Intraocular Lens Implantation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kwon</surname><given-names>Sang Won</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Moon</surname><given-names>Hyun Seung</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Shyn</surname><given-names>Kyung Hwan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib></contrib-group><aff id="A1">Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.</aff><author-notes><corresp>Reprint requests to Kyung Hwan Shyn, MD, Department of Ophthalmology, Gachon Medical School, Gil Medical Center, #1198 Guwol-dong, Namdong-gu, Incheon 405-760, Korea. Tel: 82-32-460-3758, Fax: 82-32-460-3358, <email>khshyn@gilhospital.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>30</day><month>6</month><year>2006</year></pub-date><volume>20</volume><issue>2</issue><fpage>87</fpage><lpage>92</lpage><history><date date-type="received"><day>03</day><month>11</month><year>2005</year></date><date date-type="accepted"><day>06</day><month>4</month><year>2006</year></date></history><permissions><copyright-statement>Copyright © 2006 by the Korean Ophthalmological Society</copyright-statement><copyright-year>2006</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>To evaluate the efficacy and safety of angle-supported phakic anterior chamber intraocular lenses in amblyopic adult eyes with very high myopia.</p></sec><sec><title>Methods</title><p>We evaluated 12 eyes in nine patients with very high myopic amblyopia who received angle-supported phakic intraocular lenses (Phakic 6H®) and followed them for more than six months. Uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), and complications were evaluated. A satisfaction score was rated by patients using a 5-point (1~5) numeric scale.</p></sec><sec><title>Results</title><p>The mean age of patients was 37.3±9.4 years, ranging from 29 to 59 years old. The preoperative mean refraction (spherical equivalent, SE) was -20.10±5.41 diopters (D). The postoperative mean refraction (SE) was -1.75±0.76 D at six months. The postoperative BCVA improved an average 3.92±1.24 lines over preoperative values, and mean endothelial cell loss was 8.9% at six months. Development of cataracts, glaucoma, and pupil abnormalities were not demonstrated in any case during the study. The patients were all very satisfied, as the average satisfaction score was 4.3.</p></sec><sec><title>Conclusions</title><p>This study indicates that angle-supported phakic anterior chamber intraocular lens implantation may be an effective surgical alternative for the correction of amblyopic adult eyes with very high myopia. However, long-term evaluation is necessary to assess possible complications and long-term safety.</p></sec></abstract><kwd-group><kwd>Amblyopia</kwd><kwd>High myopia</kwd><kwd>Phakic anterior chamber lens</kwd></kwd-group></article-meta></front><body><p>The surgical correction of very high myopia currently includes clear lens extraction,<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref> anterior and posterior chamber intraocular lens (IOL) implantation,<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B4">4</xref> and keratorefractive surgeries such as photorefractive keratectomy (PRK), laser <italic>in situ</italic> keratomileusis (LASIK), and radial keratotomy.<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B6">6</xref> However, clear lens extraction is associated with increased risk of retinal detachment, cystoid macular edema, endothelial cell loss, and endophthalmitis.<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B7">7</xref> Keratorefractive surgeries are associated with iatrogenic keratectasia, significant optical aberrations, regression, poor quality of vision, and poor predictability when used to correct high myopia.<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B8">8</xref>-<xref ref-type="bibr" rid="B11">11</xref></p><p>The implantation of phakic IOLs is an emerging technology in the treatment of high ametropia, since it avoids both the unpredictability of PRK and LASIK and the loss of accommodation of clear lens extraction.<xref ref-type="bibr" rid="B12">12</xref> Phakic IOLs have significant advantages such as reversibility, immediate correction, stability, and relative simplicity.<xref ref-type="bibr" rid="B12">12</xref>-<xref ref-type="bibr" rid="B14">14</xref> However, long-term studies are necessary to assess potential risks to the corneal endothelium, anterior uvea, and crystalline lens.<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B7">7</xref></p><p>The purpose of this study was to evaluate the efficacy, stability, and safety of angle-supported phakic anterior chamber intraocular lenses (PAC IOLs) in amblyopic adult eyes with very high myopia.</p><sec sec-type="materials|methods"><title>Materials and Methods</title><p>Angle-supported phakic IOLs (Phakic 6H®, Ophthalmic Innovations International Inc., USA) were implanted in adult amblyopic eyes with very high myopia between April 2001 and August 2003 by the same surgeon (K.H.S.). Inclusion criteria were: age of 20 years or older, myopia of -12.0D or higher in spherical equivalent, a BCVA of 20/70 or worse, anterior chamber depth (ACD) of at least 2.8 mm, endothelial cell count of at least 2,500 cells/mm<sup>2</sup>, and a wide-open angle (20~40 degrees) by the Shaffer's gonioscopic classification.<xref ref-type="bibr" rid="B15">15</xref> Exclusion criteria included glaucoma, cataract, keratoconus, history of uveitis, corneal dystrophy, previous ocular surgery, and systemic diseases such as diabetes or hypertension, autoimmune diseases, and connective tissue diseases.</p><p>A preoperative ocular examination was conducted on each patient to evaluate distance UCVA and BCVA using a Snellen chart, manifest and cycloplegic refractions, Goldmann applanation tonometry, keratometry, corneal topography, slit lamp and fundus, gonioscopy, ultrasound pachymetry, white-to-white (WTW) limbal dimension, endothelial cell count (Cellcheck CC-7000, Konan), anterior chamber depth estimation by ultrasound A-scan, and pupil diameter.</p><p>All visual acuities were measured using letters on the Snellen chart and recorded in a standardized fashion, in which each letter read on a complete line was noted accordingly. Preoperative BCVA, postoperative UCVA, and postoperative BCVA were recorded in logMAR units; a change of 0.1 unit corresponded to a line of vision.</p><p>Lens-power calculations were performed with formulae developed by Ophthalmic Innovations International Inc. The overall diameter of the phakic IOL to be implanted was determined by measuring the WTW diameter with a caliper and then adding 1 mm. The target postoperative mean refraction (SE) was emmetropia.</p><sec><title>Surgical Procedure</title><p>Preoperative preparations included administration of 2% pilocarpine drops to the operative eye at 15-minute intervals and 15% mannitol 300 cc intravenously one hour prior to surgery. Nadbath akinesia and retrobulbar anesthesia with 2% lidocaine were used. One 1-mm paracentesis was made at the 3 o'clock position. A small amount of viscoelastic agent (Healon®, Pharmacia, Sweden) was injected to maintain a stable anterior chamber throughout the surgical procedure. A 7-mm valved limbal incision was created between the 10 and 2 o'clock positions with a bevel-up crescent knife. A 7-mm lens glide was introduced into the anterior chamber down to the 6 o'clock position, taking care to avoid contact with the iris, endothelium, and crystalline lens. The viscoelastic agent was again injected over the glide sheet. The phakic IOL was then introduced toward the 6 o'clock position and the glide was withdrawn. The phakic IOL was rotated to the meridian in which the pupil was best centered. After the lens had been placed in the eye, its stability was tested by pressing on the limbus in the meridian of the long axis of the lens to observe any unexpected movements or displacements of the lens. A peripheral iridectomy was performed using Vannas scissors. The incision site was closed with 10-0 nylon-interrupted sutures. Before the knot was tied, irrigation of the anterior chamber with a balanced salt solution was performed to remove any remaining viscoelastic agent. The suture was then knotted. Topical ofloxacin ointment was given at the end of surgery and the surgical site patched for 24 hours.</p><p>Postoperatively, 1% prednisone acetate (Pred Forte®, Allergan, USA) and 0.3% Ofloxacin (Tarivid®, Santen, Japan) were prescribed. Follow-up examinations were made at one day, one week and one, two, three, and six months following surgery. ANOVA was used to assess the significance of differences among subjects between repeated measurements.</p><p>The patients' satisfaction of vision was evaluated at six months postoperatively using a questionnaire. Patients were asked to subjectively evaluate their level of visual difficulty on a 5-point scale in five situations: distance vision, near vision, night halo and glare, improvement of working efficiency, and overall satisfaction. Response options were: 1=major trouble; 2=a great deal of trouble; 3=moderately satisfied; 4=satisfied; 5=very satisfied.</p></sec></sec><sec sec-type="results"><title>Results</title><p>A total of 12 eyes in nine consecutive patients were recruited to the study, with six males and three females being followed for more than six months. The mean patient age was 37.3 years (ranging from 29 to 59 years). The preoperative mean UCVA was 0.01 (ranging from CF 30 cm to 0.04), and the mean BCVA was 0.18 (ranging from 0.1 to 0.3). The preoperative mean refraction (SE) was -20.10±5.41D. The mean WTW diameter was 11.2±0.4 mm (ranging from 11 to 12 mm), the mean overall diameter of the implanted phakic IOLs was 12.4±0.5 mm (ranging from 12 to 13 mm), and the mean power of phakic IOLs was -18.54±4.34D (ranging from -12.5 to -25.0D) (<xref ref-type="table" rid="T1">Table 1</xref>).</p><p>The postoperative mean SE was -1.74±0.92D (ranging from -0.625 to -2.375D) at one week and -1.75±0.76D (ranging from -1.25 to -2.00D) at six months (<xref ref-type="table" rid="T2">Table 2</xref>). There was no significant change in postoperative SE refraction at one week and one, two, three, and six months (p=0.83) (<xref ref-type="fig" rid="F1">Fig. 1</xref>).</p><p>Mean postoperative UCVA was 0.24 (ranging from 0.1 to 0.6) at one week, 0.34 (ranging from 0.2 to 0.8) at one month and 0.40 (ranging from 0.2 to 0.8) at six months. Mean postoperative BCVA was 0.39 (ranging from 0.2 to 0.7) at one week, 0.44 (ranging from 0.2 to 0.8) at one month and 0.49 (ranging from 0.3 to 0.9) at six months (<xref ref-type="table" rid="T3">Table 3</xref>). The postoperative BCVA improved an average of 3.92±1.24 lines (logMAR) compared with the preoperative values at six months (<xref ref-type="fig" rid="F2">Fig. 2</xref>).</p><p>The preoperative mean endothelial cell density was 3315±31 cells/mm<sup>2</sup>. After surgery, this decreased to 3128±512 cells/mm<sup>2</sup> at one month, 3021±609 cells/mm<sup>2</sup> at six months. The percentage of endothelial cell loss was 8.9% at six months (<xref ref-type="fig" rid="F3">Fig. 3</xref>). The preoperative mean IOP was 14.5±1.83 mmHg. After surgery, this increased to 17.1±1.85 mmHg at one week, and 15.1±2.01 mmHg at six months. None of the patients required glaucoma therapy to control IOP elevation continuously. The preoperative mean anterior chamber depth (ACD) was 3.40±0.24 mm. At six months, the mean ACD was 3.00±0.33 mm (a 4.1% decrease).</p><p>Development of complications such as cataracts, glaucoma, chronic uveitis, retinal detachment, endophthalmitis, IOL dislocation, and pupil abnormality were not demonstrated in any case during the study. The patients were all very satisfied and the average satisfaction score was 4.3 (<xref ref-type="fig" rid="F4">Fig. 4</xref>).</p></sec><sec sec-type="discussion"><title>Discussion</title><p>Refractive correction of very high myopia is a difficult clinical problem. At this time, there is no satisfactory surgical procedure for the correction of very high myopia. The upper limit of correction that can be achieved with radial keratotomy is generally thought to be -8.0D.<xref ref-type="bibr" rid="B16">16</xref> Although no precise limits have been determined, most surgeons do not perform LASIK in eyes with myopia higher than -12.0D.<xref ref-type="bibr" rid="B17">17</xref> PRK has generated high expectations for the correction of low and moderate myopia. However, keratorefractive surgeries for the correction of very high myopia can be problematic because of limited predictability and the potential for irreversibility, regression, and corneal haze.<xref ref-type="bibr" rid="B6">6</xref>,<xref ref-type="bibr" rid="B18">18</xref> Clear lens extraction followed by implantation of low-power IOLs have not gained wide acceptance due to complications such as retinal detachment, which can lead to early loss of accommodation in relatively young patients.<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B6">6</xref></p><p>Phakic IOLs are increasingly popular with refractive surgeons because of refractive predictability and stability, and because they do not alter accommodation.<xref ref-type="bibr" rid="B19">19</xref> All of the above-mentioned reasons support the use of PAC IOLs for the correction of refractive errors. However, there are potentially important risks that need to be clarified before the procedure is put into general use.</p><p>One important risk is that angle-supported phakic IOLs may induce damage to the anterior chamber structures and break-downs in the blood-aqueous barrier. Changes in blood-aqueous barrier permeability could induce metabolic lens disturbances. These disturbances might accelerate cataract development, while anterior chamber inflammation could induce corneal endothelium damage and increase intraocular pressure.<xref ref-type="bibr" rid="B20">20</xref> In this study, endothelial cell loss was 8.9% at six months and serious endothelial damage did not occur. Presently, new models of angle-supported phakic IOLs have been modified to avoid these problems; however, long-term studies are necessary to assess the potential risks of these new models.</p><p>The potential for intraocular pressure elevation may be related to pupillary block in the early postoperative period, with some investigators demonstrating a mean incidence of 4.8~7.2%.<xref ref-type="bibr" rid="B21">21</xref>,<xref ref-type="bibr" rid="B22">22</xref> It is proposed that the preoperative iridectomy contributed to the prevention of intraocular pressure elevation in our study.</p><p>The pupil-related problems such as iris atrophy, iris retraction, pupil ovalization and others may be induced when large angle-supported intraocular lenses (compared to patients' corneal diameter) are inserted. Thus, an anterior chamber IOL with a flexible haptic is required to prevent these problems.<xref ref-type="bibr" rid="B23">23</xref> In our study, iris complications did not occur, although the total number of cases in this study was relatively small.</p><p>Compared to phakic posterior chamber intraocular lenses, the phakic anterior chamber intraocular lens has the advantage that glare incidence is lower due to its larger optic. However, Phakic 6H® needs further improvement due to surveys of patient satisfaction level in which most patients did not give above average grades for glare and halo symptoms.</p><p>Another complication posed by the implantation of a phakic IOL is the possibility of inducing cataracts.<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B22">22</xref> Phakic posterior chamber intraocular lenses may contact the crystalline lens during accommodation, thus increasing the possibility of cataract formation.<xref ref-type="bibr" rid="B22">22</xref>,<xref ref-type="bibr" rid="B24">24</xref> Lackner et al.<xref ref-type="bibr" rid="B25">25</xref> reported lens opacification in 11 (14.5%) of 76 myopic eyes, and Pineda-Fernandez et al.<xref ref-type="bibr" rid="B3">3</xref> reported opacification in two (11.1%) of 18 very highly-myopic eyes after implantation of phakic posterior chamber IOLs.</p><p>Amblyopia is a reduction in visual acuity as a result of a developmental disorder of spatial vision arising from strabismus, anisometropia, or from deprivation early in life.<xref ref-type="bibr" rid="B26">26</xref> The following are known to cause amblyopia in very high-myopia patients: difficulty to fit accurate images on the retina through full refractive correction, small image sizes due to the lens effect, narrow visual fields, and the possibility of manifesting very high order aberrations and so forth.<xref ref-type="bibr" rid="B27">27</xref></p><p>The visual system is thought to be sensitive to the effects of normal experience only during a limited period of time early in life, when it is immature and plastic. Accordingly, therapy for amblyopia does not offer significant therapeutic effects for patients over the age of 10. As such, no clear method is suggested today as a therapeutic method for adult amblyopia.<xref ref-type="bibr" rid="B28">28</xref> Generally in the case of very high myopia with amblyopia, most use spectacles or contact lenses.</p><p>There have been limited efforts to improve amblyopia in adults, even slightly, because of the suspected permanency of the deficit. Nevertheless, several reports now describe the satisfactory treatment of amblyopia with improvements in BCVA in older children and adults.<xref ref-type="bibr" rid="B28">28</xref>-<xref ref-type="bibr" rid="B32">32</xref> Wick et al.<xref ref-type="bibr" rid="B29">29</xref> and Simmers and Gray<xref ref-type="bibr" rid="B30">30</xref> claim that age is not a critical factor for the outbreak of amblyopia therapy, and that conventional therapy for amblyopia such as full refractive correction, occlusion therapy, prism prescription and so forth can help improve visual function in adult amblyopia patients. Sakatani et al.<xref ref-type="bibr" rid="B31">31</xref> and Barequet et al.<xref ref-type="bibr" rid="B32">32</xref> reported that improvement in best corrected visual acuity resulted after performing LASIK surgery on adult amblyopia patients.</p><p>In this study, we were able to improve best corrected visual acuity through phakic anterior chamber intraocular lens insertion in adult amblyopic eyes with very high myopia. The mechanism of refractive surgeries that improves vision is considered to be the effect of the magnification of the image and refinement at the corneal or lenticular plane rather than the spectacle plane.<xref ref-type="bibr" rid="B27">27</xref>,<xref ref-type="bibr" rid="B31">31</xref> According to conventional concepts, treatment of adult amblyopia is ineffectual; but by given previous reports<xref ref-type="bibr" rid="B28">28</xref>-<xref ref-type="bibr" rid="B32">32</xref> and this study, it is possible to assume that numerous patients are classified as amblyopia because therapy that may appropriately induce emmetropia has not been attempted in them.</p><p>This study indicates that angle-supported phakic anterior chamber IOL implantation may be an effective surgical alternative for the correction of amblyopic adult eyes with high myopia. However, long-term evaluation is needed to assess possible complications such as cataract, glaucoma, endothelial cell loss, and long-term safety.</p></sec></body><back><fn-group><fn fn-type="conflict"><p>None of the authors have a financial or proprietary interest in any material or method mentioned.</p></fn><fn fn-type="presented-at"><p>This study was presented at the American Society of Cataract and Refractive Surgery, San Diego, CA, May 2004</p></fn></fn-group><ref-list><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arne</surname><given-names>JL</given-names></name></person-group><article-title>Phakic intraocular lens implantation versus clear lens extraction in highly myopic eyes of 30- to 50-year-old patients</article-title><source>J Cataract Refract Surg</source><year>2004</year><volume>30</volume><fpage>2092</fpage><lpage>2096</lpage><pub-id pub-id-type="pmid">15474820</pub-id></element-citation></ref><ref id="B2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Colin</surname><given-names>J</given-names></name><name><surname>Robinet</surname><given-names>A</given-names></name><name><surname>Cochener</surname><given-names>B</given-names></name></person-group><article-title>Retinal detachment after clear lens extraction for high myopia; seven-year follow-up</article-title><source>Ophthalmology</source><year>1999</year><volume>106</volume><fpage>2281</fpage><lpage>2284</lpage><pub-id pub-id-type="pmid">10599657</pub-id></element-citation></ref><ref id="B3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pineda-Fernandez</surname><given-names>A</given-names></name><name><surname>Jaramillo</surname><given-names>J</given-names></name><name><surname>Vargas</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Phakic posterior chamber intraocular lens for high myopia</article-title><source>J Cataract Refract Surg</source><year>2004</year><volume>30</volume><fpage>2277</fpage><lpage>2283</lpage><pub-id pub-id-type="pmid">15519075</pub-id></element-citation></ref><ref id="B4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Menezo</surname><given-names>JL</given-names></name><name><surname>Peris-Martinez</surname><given-names>C</given-names></name><name><surname>Cisneros</surname><given-names>AL</given-names></name><name><surname>Martinez-Costa</surname><given-names>R</given-names></name></person-group><article-title>Phakic intraocular lenses to correct high myopia: Adatomed, Staar, and Artisan</article-title><source>J Cataract Refract Surg</source><year>2004</year><volume>30</volume><fpage>33</fpage><lpage>44</lpage><pub-id pub-id-type="pmid">14967266</pub-id></element-citation></ref><ref id="B5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lyle</surname><given-names>WA</given-names></name><name><surname>Jin</surname><given-names>GJ</given-names></name></person-group><article-title>Laser in situ keratomileusis with the VISX star laser for myopia over 10.0 dipoters</article-title><source>J Cataract Refract Surg</source><year>2001</year><volume>27</volume><fpage>1812</fpage><lpage>1822</lpage><pub-id pub-id-type="pmid">11709256</pub-id></element-citation></ref><ref id="B6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sher</surname><given-names>NA</given-names></name><name><surname>Barak</surname><given-names>M</given-names></name><name><surname>Daya</surname><given-names>S</given-names></name></person-group><article-title>Excimer laser photorefractive keratectomy in high myopia; a multicenter study</article-title><source>Arch Ophthalmol</source><year>1992</year><volume>110</volume><fpage>935</fpage><lpage>943</lpage><pub-id pub-id-type="pmid">1637278</pub-id></element-citation></ref><ref id="B7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huber</surname><given-names>C</given-names></name></person-group><article-title>Effectiveness of intraocular lens calculation in high ametropia</article-title><source>J Cataract Refract Surg</source><year>1989</year><volume>15</volume><fpage>667</fpage><lpage>672</lpage><pub-id pub-id-type="pmid">2614711</pub-id></element-citation></ref><ref id="B8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pallikaris</surname><given-names>IG</given-names></name><name><surname>Papatzanak</surname><given-names>ME</given-names></name><name><surname>Stathi</surname><given-names>EZ</given-names></name></person-group><article-title>Laser in situ keratomileusis</article-title><source>Laser Surg Med</source><year>1990</year><volume>10</volume><fpage>463</fpage><lpage>468</lpage></element-citation></ref><ref id="B9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Geggel</surname><given-names>HS</given-names></name><name><surname>Talley</surname><given-names>AR</given-names></name></person-group><article-title>Delayed onset keratectasia following laser in situ keratomileusis and photorefractive keratectomy</article-title><source>Ophthalmology</source><year>2000</year><volume>107</volume><fpage>640</fpage><lpage>652</lpage><pub-id pub-id-type="pmid">10768325</pub-id></element-citation></ref><ref id="B10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Holladay</surname><given-names>JT</given-names></name><name><surname>Dudeja</surname><given-names>KR</given-names></name><name><surname>Chang</surname><given-names>J</given-names></name></person-group><article-title>Functional vision and corneal changes after laser in situ keratomileusis determined by contrast sensitivity, glare testing, and corneal topography</article-title><source>J Cataract Refract Surg</source><year>1999</year><volume>25</volume><fpage>663</fpage><lpage>669</lpage><pub-id pub-id-type="pmid">10330642</pub-id></element-citation></ref><ref id="B11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oshika</surname><given-names>T</given-names></name><name><surname>Klyce</surname><given-names>SD</given-names></name><name><surname>Applegate</surname><given-names>RA</given-names></name><etal></etal></person-group><article-title>Comparison of corneal wavefront aberrations after photorefractive keratectomy and laser in situ keratomileusis</article-title><source>Am J Ophthalmol</source><year>1999</year><volume>127</volume><fpage>1</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">9932992</pub-id></element-citation></ref><ref id="B12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pesando</surname><given-names>PM</given-names></name><name><surname>Ghiringhello</surname><given-names>MP</given-names></name><name><surname>Tagliavacche</surname><given-names>P</given-names></name></person-group><article-title>Posterior chamber collamer phakic intraocular lens for myopia and hyperopia</article-title><source>J Refract Surg</source><year>1999</year><volume>15</volume><fpage>415</fpage><lpage>423</lpage><pub-id pub-id-type="pmid">10445712</pub-id></element-citation></ref><ref id="B13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Allemann</surname><given-names>N</given-names></name><name><surname>Chamon</surname><given-names>W</given-names></name><name><surname>Tanaka</surname><given-names>HM</given-names></name><etal></etal></person-group><article-title>Myopic angle-supported intraocular lenses: two-year follow-up</article-title><source>Ophthalmology</source><year>2000</year><volume>107</volume><fpage>1549</fpage><lpage>1554</lpage><pub-id pub-id-type="pmid">10919906</pub-id></element-citation></ref><ref id="B14"><label>14</label><element-citation publication-type="journal"><collab>The Implantable Contact Lens in Treatment of Myopia Study Group</collab><article-title>U.S. Food and Drug Administration clinical trial of the Implantable Contact Lens for moderate to high myopia</article-title><source>Ophthalmology</source><year>2003</year><volume>110</volume><fpage>255</fpage><lpage>266</lpage><pub-id pub-id-type="pmid">12578765</pub-id></element-citation></ref><ref id="B15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>RJ</given-names></name></person-group><article-title>A new method of estimating the depth of the anterior chamber</article-title><source>Br J Ophthalmol</source><year>1979</year><volume>63</volume><fpage>215</fpage><lpage>220</lpage><pub-id pub-id-type="pmid">435435</pub-id></element-citation></ref><ref id="B16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Waring</surname><given-names>GO</given-names><suffix>3rd</suffix></name><name><surname>Lynn</surname><given-names>MJ</given-names></name><name><surname>Nizam</surname><given-names>A</given-names></name><etal></etal></person-group><collab>The Perk Study Group</collab><article-title>Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study five years after surgery</article-title><source>Ophthalmology</source><year>1991</year><volume>98</volume><fpage>1164</fpage><lpage>1176</lpage><pub-id pub-id-type="pmid">1923352</pub-id></element-citation></ref><ref id="B17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Buratto</surname><given-names>L</given-names></name><name><surname>Ferrari</surname><given-names>M</given-names></name></person-group><article-title>Indications, techniques, results, limits, and complications of laser in situ keratomileusis</article-title><source>Curr Opin Ophthalmol</source><year>1997</year><volume>8</volume><fpage>59</fpage><lpage>66</lpage><pub-id pub-id-type="pmid">10170446</pub-id></element-citation></ref><ref id="B18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dutt</surname><given-names>S</given-names></name><name><surname>Steinert</surname><given-names>RF</given-names></name><name><surname>Raizman</surname><given-names>MB</given-names></name><name><surname>Puliafito</surname><given-names>CA</given-names></name></person-group><article-title>One-year results of excimer laser photorefractive keratectomy for low to moderate myopia</article-title><source>Arch Ophthalmol</source><year>1994</year><volume>112</volume><fpage>1427</fpage><lpage>1436</lpage><pub-id pub-id-type="pmid">7980132</pub-id></element-citation></ref><ref id="B19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Assetto</surname><given-names>V</given-names></name><name><surname>Benedetti</surname><given-names>S</given-names></name><name><surname>Pesando</surname><given-names>P</given-names></name></person-group><article-title>Collamer intraocular contact lens to correct high myopia</article-title><source>J Cataract Refract Surg</source><year>1996</year><volume>22</volume><fpage>551</fpage><lpage>556</lpage><pub-id pub-id-type="pmid">8784624</pub-id></element-citation></ref><ref id="B20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Perez-Santonja</surname><given-names>JJ</given-names></name><name><surname>Iradier</surname><given-names>MT</given-names></name><name><surname>Benitez del Castillo</surname><given-names>JM</given-names></name><etal></etal></person-group><article-title>Chronic subclinical inflammation in phakic eyes with intraocular lenses to correct myopia</article-title><source>J Cataract Refract Surg</source><year>1996</year><volume>22</volume><fpage>183</fpage><lpage>187</lpage><pub-id pub-id-type="pmid">8656382</pub-id></element-citation></ref><ref id="B21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alio</surname><given-names>JL</given-names></name><name><surname>de la Hoz</surname><given-names>F</given-names></name><name><surname>Perez-Santonja</surname><given-names>JJ</given-names></name><etal></etal></person-group><article-title>Phakic anterior chamber lenses for the correction of myopia: a 7 year cumulative analysis of complications in 263 cases</article-title><source>Ophthalmology</source><year>1999</year><volume>106</volume><fpage>458</fpage><lpage>466</lpage><pub-id pub-id-type="pmid">10080200</pub-id></element-citation></ref><ref id="B22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zaldivar</surname><given-names>R</given-names></name><name><surname>Davidorff</surname><given-names>JM</given-names></name><name><surname>Oscherow</surname><given-names>S</given-names></name></person-group><article-title>Posterior chamber phakic intraocular lens for myopia of -8 to -19 diopters</article-title><source>J Refract Surg</source><year>1998</year><volume>14</volume><fpage>294</fpage><lpage>305</lpage><pub-id pub-id-type="pmid">9641420</pub-id></element-citation></ref><ref id="B23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baikoff</surname><given-names>G</given-names></name><name><surname>Arne</surname><given-names>JL</given-names></name><name><surname>Bokobza</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Angle-fixated anterior chamber phakic intraocular lens for myopia of -7 to -19 diopters</article-title><source>J Refract Surg</source><year>1998</year><volume>14</volume><fpage>282</fpage><lpage>293</lpage><pub-id pub-id-type="pmid">9641419</pub-id></element-citation></ref><ref id="B24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jean</surname><given-names>LA</given-names></name><name><surname>Laurence</surname><given-names>CL</given-names></name></person-group><article-title>Phakic posterior chamber lenses for high myopia: Functional and anatomical outcomes</article-title><source>J Cataract Refract Surg</source><year>2000</year><volume>26</volume><fpage>369</fpage><lpage>374</lpage><pub-id pub-id-type="pmid">10713231</pub-id></element-citation></ref><ref id="B25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lackner</surname><given-names>B</given-names></name><name><surname>Pieh</surname><given-names>S</given-names></name><name><surname>Schmidinger</surname><given-names>G</given-names></name><etal></etal></person-group><article-title>Long-term results of implantation of phakic posterior chamber intraocular lenses</article-title><source>J Cataract Refract Surg</source><year>2004</year><volume>30</volume><fpage>2269</fpage><lpage>2276</lpage><pub-id pub-id-type="pmid">15519074</pub-id></element-citation></ref><ref id="B26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Campos</surname><given-names>E</given-names></name></person-group><article-title>Amblyopia</article-title><source>Surv Ophthalmol</source><year>1995</year><volume>40</volume><fpage>23</fpage><lpage>39</lpage><pub-id pub-id-type="pmid">8545799</pub-id></element-citation></ref><ref id="B27"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Applegate</surname><given-names>RA</given-names></name><name><surname>Howland</surname><given-names>HC</given-names></name></person-group><article-title>Magnification and visual acuity in refractive surgery</article-title><source>Arch Ophthalmol</source><year>1993</year><volume>111</volume><fpage>1335</fpage><lpage>1342</lpage><pub-id pub-id-type="pmid">8216013</pub-id></element-citation></ref><ref id="B28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>El Mallah</surname><given-names>MK</given-names></name><name><surname>Chakravarthy</surname><given-names>U</given-names></name><name><surname>Hart</surname><given-names>PM</given-names></name></person-group><article-title>Amblyopia: is visual loss permanent?</article-title><source>Br J Ophthalmol</source><year>2000</year><volume>84</volume><fpage>952</fpage><lpage>956</lpage><pub-id pub-id-type="pmid">10966943</pub-id></element-citation></ref><ref id="B29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wick</surname><given-names>B</given-names></name><name><surname>Wingard</surname><given-names>M</given-names></name><name><surname>Cotter</surname><given-names>S</given-names></name><name><surname>Scheiman</surname><given-names>M</given-names></name></person-group><article-title>Anisometropic amblyopia: is the patient ever too old to treat?</article-title><source>Optom Vis Sci</source><year>1992</year><volume>69</volume><fpage>866</fpage><lpage>878</lpage><pub-id pub-id-type="pmid">1454304</pub-id></element-citation></ref><ref id="B30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Simmers</surname><given-names>AJ</given-names></name><name><surname>Gray</surname><given-names>LS</given-names></name></person-group><article-title>Improvement of visual function in an adult amblyope</article-title><source>Optom Vis Sci</source><year>1999</year><volume>76</volume><fpage>82</fpage><lpage>87</lpage><pub-id pub-id-type="pmid">10082053</pub-id></element-citation></ref><ref id="B31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sakatani</surname><given-names>K</given-names></name><name><surname>Jabbur</surname><given-names>NS</given-names></name><name><surname>O'Brien</surname><given-names>TP</given-names></name></person-group><article-title>Improvement in best corrected visual acuity in amblyopic adult eyes after laser in situ keratomileusis</article-title><source>J Cataract Refract Surg</source><year>2004</year><volume>30</volume><fpage>2517</fpage><lpage>2521</lpage><pub-id pub-id-type="pmid">15617918</pub-id></element-citation></ref><ref id="B32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barequet</surname><given-names>IS</given-names></name><name><surname>Wygnanski-Jaffe</surname><given-names>T</given-names></name><name><surname>Hirsh</surname><given-names>A</given-names></name></person-group><article-title>Laser in situ keratomileusis improves visual acuity in some adult eyes with amblyopia</article-title><source>J Refract Surg</source><year>2004</year><volume>20</volume><fpage>25</fpage><lpage>28</lpage><pub-id pub-id-type="pmid">14763467</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="F1" position="float"><label>Fig. 1</label><caption><p>Stability of postoperative refraction. Postoperative refraction observed at 1 week remained at 1, 2, 3 and 6 months. (Repeated measures ANOVA within-subjects; p=0.83)</p><p>SE=spherical equivalent.</p></caption><graphic xlink:href="kjo-20-87-g001"></graphic></fig><fig id="F2" position="float"><label>Fig. 2</label><caption><p>Changes in postoperative BCVA at 6 months (12 eyes). MAR: minimum angle of resolution.</p></caption><graphic xlink:href="kjo-20-87-g002"></graphic></fig><fig id="F3" position="float"><label>Fig. 3</label><caption><p>Changes in endothelial cell count following phakic anterior chamber IOL implantation.</p></caption><graphic xlink:href="kjo-20-87-g003"></graphic></fig><fig id="F4" position="float"><label>Fig. 4</label><caption><p>Subjective six-month postoperative evaluation of quality of vision in patients with phakic anterior chamber IOLs operation.</p></caption><graphic xlink:href="kjo-20-87-g004"></graphic></fig><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Preoperative evaluation of patients</p></caption><graphic xlink:href="kjo-20-87-i001"></graphic><table-wrap-foot><fn><p>ACL: anterior chamber IOLs, BSCVA: best spectacle-corrected visual acuity, CL: contact lens, CF: counting finger, H: hard type contact lens, MAR: minimum angle of resolution, S: soft type contact lens, UCVA: uncorrected visual acuity, WTW: white-to-white.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Changes in manifest refraction over time in patients with phakic anterior chamber IOLs (n=12 eyes)</p></caption><graphic xlink:href="kjo-20-87-i002"></graphic></table-wrap><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Preoperative UCVA and BCVA and 6-month postoperative UCVA and BCVA in 12 eyes</p></caption><graphic xlink:href="kjo-20-87-i003"></graphic><table-wrap-foot><fn><p>BCVA: best-corrected visual acuity, CF: counting finger, MAR: minimum angle of resolution, UCVA: uncorrected visual acuity.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kwon, Sang Won" sort="Kwon, Sang Won" uniqKey="Kwon S" first="Sang Won" last="Kwon">Sang Won Kwon</name></noRegion><name sortKey="Moon, Hyun Seung" sort="Moon, Hyun Seung" uniqKey="Moon H" first="Hyun Seung" last="Moon">Hyun Seung Moon</name><name sortKey="Shyn, Kyung Hwan" sort="Shyn, Kyung Hwan" uniqKey="Shyn K" first="Kyung Hwan" last="Shyn">Kyung Hwan Shyn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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