Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications
Identifieur interne : 002C24 ( Ncbi/Curation ); précédent : 002C23; suivant : 002C25Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications
Auteurs : Fan Chen [République populaire de Chine] ; Zhifeng Qi [République populaire de Chine] ; Yuming Luo [République populaire de Chine] ; Taylor Hinchliffe [États-Unis] ; Guanghong Ding [République populaire de Chine] ; Ying Xia [États-Unis] ; Xunming Ji [République populaire de Chine]Source :
- Progress in neurobiology [ 0301-0082 ] ; 2014.
Abstract
Stroke is deemed a worldwide leading cause of neurological disability and death, however, there is currently no promising pharmacotherapy for acute ischemic stroke aside from intravenous or intra-arterial thrombolysis. Yet because of the narrow therapeutic time window involved, thrombolytic application is very restricted in clinical settings. Accumulating data suggest that non-pharmaceutical therapies for stroke might provide new opportunities for stroke treatment. Here we review recent research progress in the mechanisms and clinical implications of non-pharmaceutical therapies, mainly including neuroprotective approaches such as hypothermia, ischemic/hypoxic conditioning, acupuncture, medical gases, transcranial laser therapy, etc. In addition, we briefly summarize mechanical endovascular recanalization devices and recovery devices for the treatment of the chronic phase of stroke and discuss the relative merits of these devices.
Url:
DOI: 10.1016/j.pneurobio.2013.12.007
PubMed: 24407111
PubMed Central: 3969942
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<front><div type="abstract" xml:lang="en"><p id="P2">Stroke is deemed a worldwide leading cause of neurological disability and death, however, there is currently no promising pharmacotherapy for acute ischemic stroke aside from intravenous or intra-arterial thrombolysis. Yet because of the narrow therapeutic time window involved, thrombolytic application is very restricted in clinical settings. Accumulating data suggest that non-pharmaceutical therapies for stroke might provide new opportunities for stroke treatment. Here we review recent research progress in the mechanisms and clinical implications of non-pharmaceutical therapies, mainly including neuroprotective approaches such as hypothermia, ischemic/hypoxic conditioning, acupuncture, medical gases, transcranial laser therapy, etc. In addition, we briefly summarize mechanical endovascular recanalization devices and recovery devices for the treatment of the chronic phase of stroke and discuss the relative merits of these devices.</p>
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