Palpation Device for the Identification of Kidney and Bladder Cancer: A Pilot Study
Identifieur interne : 001B31 ( Ncbi/Curation ); précédent : 001B30; suivant : 001B32Palpation Device for the Identification of Kidney and Bladder Cancer: A Pilot Study
Auteurs : Jae Won Lee [Corée du Sud] ; Enrique Ian S. Lorenzo [Corée du Sud] ; Bummo Ahn [Corée du Sud] ; Cheol Kyu Oh [Corée du Sud] ; Hyung-Joo Kim [Corée du Sud] ; Woong Kyu Han [Corée du Sud] ; Jung Kim [Corée du Sud] ; Koon Ho Rha [Corée du Sud]Source :
- Yonsei Medical Journal [ 0513-5796 ] ; 2011.
Abstract
To determine the ability of a novel palpation device to differentiate between benign and malignant tissues of the kidney and bladder by measuring tissue elasticity.
A novel palpation device was developed, mainly composed of a micromotor, a linear position sensor, a force transducer, and a hemisphere tip and cylindrical body probe. Motion calibration as well as performance validation was done. The tissue elasticity of both benign and malignant tissues of the kidney and bladder was measured using this device. A single investigator performed the ex-vivo palpation experiment in twelve kidneys and four bladder specimens. Malignant tissues were made available from partial nephrectomy specimens and radical cystectomy specimens. Palpations for benign renal parenchyma tissue were carried out on nephroureterectomy specimens while non-involved areas in the radical cystectomy specimens were used for benign bladder samples. Elastic modulus (Young's modulus) of tissues was estimated using the Hertz-Sneddon equation from the experimental results. These were then compared using a t-test for independent samples.
Renal cell carcinoma tissues appear to be softer than normal kidney tissues, whereas tissues from urothelial carcinoma of the bladder appear to be harder than normal bladder tissues. The results from renal cell carcinoma differed significantly from those of normal kidney tissues (
Our novel palpation device can potentially differentiate between malignant and benign kidney and bladder tissues. Further studies are necessary to verify our results and define its true clinical utility.
Url:
DOI: 10.3349/ymj.2011.52.5.768
PubMed: 21786441
PubMed Central: 3159927
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<author><name sortKey="Lee, Jae Won" sort="Lee, Jae Won" uniqKey="Lee J" first="Jae Won" last="Lee">Jae Won Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Urology, Jesaeng General Hospital, Seongnam, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Urology, Jesaeng General Hospital, Seongnam</wicri:regionArea>
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<author><name sortKey="Lorenzo, Enrique Ian S" sort="Lorenzo, Enrique Ian S" uniqKey="Lorenzo E" first="Enrique Ian S." last="Lorenzo">Enrique Ian S. Lorenzo</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Urology, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Urology, Yonsei University College of Medicine, Seoul</wicri:regionArea>
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<author><name sortKey="Ahn, Bummo" sort="Ahn, Bummo" uniqKey="Ahn B" first="Bummo" last="Ahn">Bummo Ahn</name>
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<affiliation wicri:level="1"><nlm:aff id="A4">Department of Urology, Inje University College of Medicine, Busan, Korea.</nlm:aff>
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<wicri:regionArea>Department of Urology, Inje University College of Medicine, Busan</wicri:regionArea>
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<author><name sortKey="Kim, Hyung Joo" sort="Kim, Hyung Joo" uniqKey="Kim H" first="Hyung-Joo" last="Kim">Hyung-Joo Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.</nlm:aff>
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<author><name sortKey="Kim, Jung" sort="Kim, Jung" uniqKey="Kim J" first="Jung" last="Kim">Jung Kim</name>
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<author><name sortKey="Rha, Koon Ho" sort="Rha, Koon Ho" uniqKey="Rha K" first="Koon Ho" last="Rha">Koon Ho Rha</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Urology, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Urology, Yonsei University College of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
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<series><title level="j">Yonsei Medical Journal</title>
<idno type="ISSN">0513-5796</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>To determine the ability of a novel palpation device to differentiate between benign and malignant tissues of the kidney and bladder by measuring tissue elasticity.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>A novel palpation device was developed, mainly composed of a micromotor, a linear position sensor, a force transducer, and a hemisphere tip and cylindrical body probe. Motion calibration as well as performance validation was done. The tissue elasticity of both benign and malignant tissues of the kidney and bladder was measured using this device. A single investigator performed the ex-vivo palpation experiment in twelve kidneys and four bladder specimens. Malignant tissues were made available from partial nephrectomy specimens and radical cystectomy specimens. Palpations for benign renal parenchyma tissue were carried out on nephroureterectomy specimens while non-involved areas in the radical cystectomy specimens were used for benign bladder samples. Elastic modulus (Young's modulus) of tissues was estimated using the Hertz-Sneddon equation from the experimental results. These were then compared using a t-test for independent samples.</p>
</sec>
<sec><title>Results</title>
<p>Renal cell carcinoma tissues appear to be softer than normal kidney tissues, whereas tissues from urothelial carcinoma of the bladder appear to be harder than normal bladder tissues. The results from renal cell carcinoma differed significantly from those of normal kidney tissues (<italic>p</italic>
=0.002), as did urothelial carcinoma of the bladder from normal bladder tissues (<italic>p</italic>
=0.003).</p>
</sec>
<sec><title>Conclusion</title>
<p>Our novel palpation device can potentially differentiate between malignant and benign kidney and bladder tissues. Further studies are necessary to verify our results and define its true clinical utility.</p>
</sec>
</div>
</front>
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