HapticV1, Ncbi, Checkpoint, bibRecord, 002569

The oral mucosal surface and blood vessels

Identifieur interne : 002569 ( Ncbi/Checkpoint ); précédent : 002568; suivant : 002570

The oral mucosal surface and blood vessels

Auteurs : Ella A. Naumova [Allemagne] ; Tobias Dierkes [Allemagne] ; Jürgen Sprang [Allemagne] ; Wolfgang H. Arnold [Allemagne]

Source :

Head & Face Medicine [ 1746-160X ] ; 2013.

RBID : PMC:3639856

Abstract

Introduction

Detailed information about the size of the oral mucosa is scarce in the literature, and those studies that do exist do not take into account the size of the tongue or the enlargement of the surface by the papillae. Because of the various functions of the oral mucosa in the maintenance of oral health, knowledge of its true size may provide a better understanding of the physiology of the oral cavity and some oral diseases and direct future therapeutic strategies. The aim of this study was to determine the total size of the oral mucosa.

Methods

Five human adult cadaver heads were cut in the median sagittal plane, and the total area of the oral surface was determined using silicon casts. The surface of the tongue was measured with quantitative profilometry. Photographs of oral blood vessels were taken in different areas of the oral mucosa of adult test subjects using intravital microscopy, and the pictures were compared with vessel casts of the oral mucosal capillaries of a maccaca fasciculrais monkey, which was studied using a scanning electron microscope.

Results

The results showed that the dorsal side of the tongue comprises a large proportion of the total oral mucosal surface. The surface area of the epithelium increases moving from anterior to posterior on the tongue, and the number of underlying blood vessels increases proportionally.

Conclusions

It can be concluded that the back of the tongue plays an important role in the oral resorption of drugs. Clinical relevance: The results may be of relevance for the delivery and development of oral drug application.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639856

DOI: 10.1186/1746-160X-9-8
PubMed: 23497446
PubMed Central: 3639856

Affiliations:

Allemagne

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PMC:3639856

Le document en format XML

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<p>Detailed information about the size of the oral mucosa is scarce in the literature, and those studies that do exist do not take into account the size of the tongue or the enlargement of the surface by the papillae. Because of the various functions of the oral mucosa in the maintenance of oral health, knowledge of its true size may provide a better understanding of the physiology of the oral cavity and some oral diseases and direct future therapeutic strategies. The aim of this study was to determine the total size of the oral mucosa.</p>
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<p>Five human adult cadaver heads were cut in the median sagittal plane, and the total area of the oral surface was determined using silicon casts. The surface of the tongue was measured with quantitative profilometry. Photographs of oral blood vessels were taken in different areas of the oral mucosa of adult test subjects using intravital microscopy, and the pictures were compared with vessel casts of the oral mucosal capillaries of a maccaca fasciculrais monkey, which was studied using a scanning electron microscope.</p>
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<p>The results showed that the dorsal side of the tongue comprises a large proportion of the total oral mucosal surface. The surface area of the epithelium increases moving from anterior to posterior on the tongue, and the number of underlying blood vessels increases proportionally.</p>
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<p>It can be concluded that the back of the tongue plays an important role in the oral resorption of drugs. Clinical relevance: The results may be of relevance for the delivery and development of oral drug application.</p>
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The oral mucosal surface and blood vessels

The oral mucosal surface and blood vessels

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Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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Pour générer des pages wiki