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Massive cortical reorganization in sighted Braille readers

Identifieur interne : 00B116 ( Main/Merge ); précédent : 00B115; suivant : 00B117

Massive cortical reorganization in sighted Braille readers

Auteurs : Katarzyna Siuda-Krzywicka [Pologne, France] ; Łukasz Bola [Pologne] ; Małgorzata Papli Ska [Pologne] ; Ewa Sumera [Pologne] ; Katarzyna Jednor G [Pologne] ; Artur Marchewka [Pologne] ; Magdalena W. Liwi Ska [Royaume-Uni] ; Amir Amedi [Israël, France] ; Marcin Szwed [Pologne]

Source :

RBID : PMC:4805536

Abstract

The brain is capable of large-scale reorganization in blindness or after massive injury. Such reorganization crosses the division into separate sensory cortices (visual, somatosensory...). As its result, the visual cortex of the blind becomes active during tactile Braille reading. Although the possibility of such reorganization in the normal, adult brain has been raised, definitive evidence has been lacking. Here, we demonstrate such extensive reorganization in normal, sighted adults who learned Braille while their brain activity was investigated with fMRI and transcranial magnetic stimulation (TMS). Subjects showed enhanced activity for tactile reading in the visual cortex, including the visual word form area (VWFA) that was modulated by their Braille reading speed and strengthened resting-state connectivity between visual and somatosensory cortices. Moreover, TMS disruption of VWFA activity decreased their tactile reading accuracy. Our results indicate that large-scale reorganization is a viable mechanism recruited when learning complex skills.

DOI:http://dx.doi.org/10.7554/eLife.10762.001


Url:
DOI: 10.7554/eLife.10762
PubMed: 26976813
PubMed Central: 4805536

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:4805536

Le document en format XML

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<p>The brain is capable of large-scale reorganization in blindness or after massive injury. Such reorganization crosses the division into separate sensory cortices (visual, somatosensory...). As its result, the visual cortex of the blind becomes active during tactile Braille reading. Although the possibility of such reorganization in the normal, adult brain has been raised, definitive evidence has been lacking. Here, we demonstrate such extensive reorganization in normal, sighted adults who learned Braille while their brain activity was investigated with fMRI and transcranial magnetic stimulation (TMS). Subjects showed enhanced activity for tactile reading in the visual cortex, including the visual word form area (VWFA) that was modulated by their Braille reading speed and strengthened resting-state connectivity between visual and somatosensory cortices. Moreover, TMS disruption of VWFA activity decreased their tactile reading accuracy. Our results indicate that large-scale reorganization is a viable mechanism recruited when learning complex skills.</p>
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<bold>DOI:</bold>
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