Effect of heparin in irrigating solution on inflammation following small incision cataract surgery
Identifieur interne : 008F65 ( Main/Merge ); précédent : 008F64; suivant : 008F66Effect of heparin in irrigating solution on inflammation following small incision cataract surgery
Auteurs : Thomas Kohnen [Allemagne, États-Unis] ; Burkhard Dick [Allemagne] ; Volker Hessemer [Allemagne] ; Douglas D. Koch [États-Unis] ; Karl W. Jacobi [Allemagne]Source :
- Journal of Cataract & Refractive Surgery [ 0886-3350 ] ; 1998.
Abstract
Purpose: To study the effect of heparin-sodium added to the irrigating solution on postoperative inflammation in patients having cataract surgery.Setting: Department of Ophthalmology, University of Giessen, Giessen, Germany.Methods: Seventy-two patients having phacoemulsification with posterior chamber intraocular lens (IOL) implantation were randomly assigned to receive regular irrigating solution or solution with heparin-sodium (final diluted concentration 10 IU/mL). In half the patients, poly(methyi methacrylate) (PMMA) IOLs were implanted and in half, foldable silicone IOLs. The patients were examined preoperatively, on days 1 and 3, and 1 year postoperatively. Postoperative inflammation was objectively evaluated by measurement of flare and cells using laser flare-cell photometry.Results: The mean postoperative flare values were significantly lower in the groups with additional heparin-sodium at days 1 and 3 (P < .01). Flare values were not significantly different 1 year postoperatively. Cell values for the heparin-treated groups were lower, but the difference did not reach statistical significance. Flare and cells values for the two IOL materials were not significantly different during the entire follow-up.Conclusion: Heparin-sodium added to the infusion solution during small incision cataract surgery reduced inflammation in the early postoperative period.
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DOI: 10.1016/S0886-3350(98)80205-8
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of heparin in irrigating solution on inflammation following small incision cataract surgery</title><author><name sortKey="Kohnen, Thomas" sort="Kohnen, Thomas" uniqKey="Kohnen T" first="Thomas" last="Kohnen">Thomas Kohnen</name></author><author><name sortKey="Dick, Burkhard" sort="Dick, Burkhard" uniqKey="Dick B" first="Burkhard" last="Dick">Burkhard Dick</name></author><author><name sortKey="Hessemer, Volker" sort="Hessemer, Volker" uniqKey="Hessemer V" first="Volker" last="Hessemer">Volker Hessemer</name></author><author><name sortKey="Koch, Douglas D" sort="Koch, Douglas D" uniqKey="Koch D" first="Douglas D." last="Koch">Douglas D. Koch</name></author><author><name sortKey="Jacobi, Karl W" sort="Jacobi, Karl W" uniqKey="Jacobi K" first="Karl W." last="Jacobi">Karl W. Jacobi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7E52EADE8B689583C8D589A897187B6540936DEC</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0886-3350(98)80205-8</idno><idno type="url">https://api.istex.fr/document/7E52EADE8B689583C8D589A897187B6540936DEC/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003388</idno><idno type="wicri:Area/Istex/Curation">003388</idno><idno type="wicri:Area/Istex/Checkpoint">003948</idno><idno type="wicri:doubleKey">0886-3350:1998:Kohnen T:effect:of:heparin</idno><idno type="wicri:Area/Main/Merge">008F65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effect of heparin in irrigating solution on inflammation following small incision cataract surgery</title><author><name sortKey="Kohnen, Thomas" sort="Kohnen, Thomas" uniqKey="Kohnen T" first="Thomas" last="Kohnen">Thomas Kohnen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt</wicri:regionArea><wicri:noRegion>Frankfurt</wicri:noRegion><wicri:noRegion>Frankfurt</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Reprint requests to Thomas Kohnen, MD, Johann Wolfgang Goethe-University, Department of Ophthalmology, Theodor-Stern-Kai 7, 60590 Frankfurt am Main</wicri:regionArea><wicri:noRegion>60590 Frankfurt am Main</wicri:noRegion><wicri:noRegion>60590 Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Dick, Burkhard" sort="Dick, Burkhard" uniqKey="Dick B" first="Burkhard" last="Dick">Burkhard Dick</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Hessemer, Volker" sort="Hessemer, Volker" uniqKey="Hessemer V" first="Volker" last="Hessemer">Volker Hessemer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Koch, Douglas D" sort="Koch, Douglas D" uniqKey="Koch D" first="Douglas D." last="Koch">Douglas D. 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Jacobi</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Cataract & Refractive Surgery</title><title level="j" type="abbrev">JCRS</title><idno type="ISSN">0886-3350</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="237">237</biblScope><biblScope unit="page" to="243">243</biblScope></imprint><idno type="ISSN">0886-3350</idno></series><idno type="istex">7E52EADE8B689583C8D589A897187B6540936DEC</idno><idno type="DOI">10.1016/S0886-3350(98)80205-8</idno><idno type="PII">S0886-3350(98)80205-8</idno><idno type="ArticleID">80205</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0886-3350</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: To study the effect of heparin-sodium added to the irrigating solution on postoperative inflammation in patients having cataract surgery.Setting: Department of Ophthalmology, University of Giessen, Giessen, Germany.Methods: Seventy-two patients having phacoemulsification with posterior chamber intraocular lens (IOL) implantation were randomly assigned to receive regular irrigating solution or solution with heparin-sodium (final diluted concentration 10 IU/mL). In half the patients, poly(methyi methacrylate) (PMMA) IOLs were implanted and in half, foldable silicone IOLs. The patients were examined preoperatively, on days 1 and 3, and 1 year postoperatively. Postoperative inflammation was objectively evaluated by measurement of flare and cells using laser flare-cell photometry.Results: The mean postoperative flare values were significantly lower in the groups with additional heparin-sodium at days 1 and 3 (P < .01). Flare values were not significantly different 1 year postoperatively. Cell values for the heparin-treated groups were lower, but the difference did not reach statistical significance. Flare and cells values for the two IOL materials were not significantly different during the entire follow-up.Conclusion: Heparin-sodium added to the infusion solution during small incision cataract surgery reduced inflammation in the early postoperative period.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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