Magnetoencephalography as a Putative Biomarker for Alzheimer's Disease
Identifieur interne : 002B36 ( Main/Merge ); précédent : 002B35; suivant : 002B37Magnetoencephalography as a Putative Biomarker for Alzheimer's Disease
Auteurs : Edward Zamrini [États-Unis] ; Fernando Maestu [Espagne] ; Eero Pekkonen [Finlande] ; Michael Funke [États-Unis] ; Jyrki Makela [Finlande] ; Myles Riley [États-Unis] ; Ricardo Bajo [Espagne] ; Gustavo Sudre [États-Unis] ; Alberto Fernandez [Espagne] ; Nazareth Castellanos [Espagne] ; Francisco Del Pozo [Espagne] ; C. J. Stam [Pays-Bas] ; Bob W. Van Dijk [Pays-Bas] ; Anto Bagic [États-Unis] ; James T. BeckerSource :
- International Journal of Alzheimer's Disease [ 2090-0252 ] ; 2011.
Abstract
Alzheimer's Disease (AD) is the most common dementia in the elderly and is estimated to affect tens of millions of people worldwide. AD is believed to have a prodromal stage lasting ten or more years. While amyloid deposits, tau filaments, and loss of brain cells are characteristics of the disease, the loss of dendritic spines and of synapses predate such changes. Popular preclinical detection strategies mainly involve cerebrospinal fluid biomarkers, magnetic resonance imaging, metabolic PET scans, and amyloid imaging. One strategy missing from this list involves neurophysiological measures, which might be more sensitive to detect alterations in brain function. The Magnetoencephalography International Consortium of Alzheimer's Disease arose out of the need to advance the use of Magnetoencephalography (MEG), as a tool in AD and pre-AD research. This paper presents a framework for using MEG in dementia research, and for short-term research priorities.
Url:
DOI: 10.4061/2011/280289
PubMed: 21547221
PubMed Central: 3087473
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PMC:3087473Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Alzheimer's Disease (AD) is the most common dementia in the elderly and is estimated to affect tens of millions of people worldwide. AD is believed to have a prodromal stage lasting ten or more years. While amyloid deposits, tau filaments, and loss of brain cells are characteristics of the disease, the loss of dendritic spines and of synapses predate such changes. Popular preclinical detection strategies mainly involve cerebrospinal fluid biomarkers, magnetic resonance imaging, metabolic PET scans, and amyloid imaging. One strategy missing from this list involves neurophysiological measures, which might be more sensitive to detect alterations in brain function. The Magnetoencephalography International Consortium of Alzheimer's Disease arose out of the need to advance the use of Magnetoencephalography (MEG), as a tool in AD and pre-AD research. This paper presents a framework for using MEG in dementia research, and for short-term research priorities.</p>
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</TEI>
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