Understanding tumor heterogeneity as functional compartments - superorganisms revisited
Identifieur interne : 002918 ( Main/Merge ); précédent : 002917; suivant : 002919Understanding tumor heterogeneity as functional compartments - superorganisms revisited
Auteurs : Thomas Gp Grunewald [Allemagne] ; Saskia M. Herbst [Allemagne] ; Jürgen Heinze [Allemagne] ; Stefan Burdach [Allemagne]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2011.
Abstract
Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."
Accordingly, we propose a model in which clonal expansion and cumulative acquisition of genetic alterations produce tumor compartments each equipped with distinct traits and thus distinct functions that cooperate to establish clinically apparent tumors. This functional compartment model also suggests mechanisms for the self-construction of tumor stem cell niches. Thus, thinking of a tumor as a superorganism will provide systemic insight into its functional compartmentalization and may even have clinical implications.
Url:
DOI: 10.1186/1479-5876-9-79
PubMed: 21619636
PubMed Central: 3118334
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superorganisms revisited</title><author><name sortKey="Grunewald, Thomas Gp" sort="Grunewald, Thomas Gp" uniqKey="Grunewald T" first="Thomas Gp" last="Grunewald">Thomas Gp Grunewald</name><affiliation wicri:level="4"><nlm:aff id="I1">Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Laboratory of Functional Genomics and Transplantation Biology, Children's Cancer Research and Roman Herzog Comprehensive Cancer Center, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory of Functional Genomics and Transplantation Biology, Children's Cancer Research and Roman Herzog Comprehensive Cancer Center, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I3">Medical Life Science and Technology Center, TUM Graduate School, Technische Universität München, Boltzmannstrasse 17, 85748 Garching, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Life Science and Technology Center, TUM Graduate School, Technische Universität München, Boltzmannstrasse 17, 85748 Garching</wicri:regionArea><wicri:noRegion>85748 Garching</wicri:noRegion><orgName type="university">Université technique de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Herbst, Saskia M" sort="Herbst, Saskia M" uniqKey="Herbst S" first="Saskia M" last="Herbst">Saskia M. Herbst</name><affiliation wicri:level="1"><nlm:aff id="I4">Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg</wicri:regionArea><wicri:noRegion>93053 Regensburg</wicri:noRegion><wicri:noRegion>93053 Regensburg</wicri:noRegion><wicri:noRegion>93053 Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Heinze, Jurgen" sort="Heinze, Jurgen" uniqKey="Heinze J" first="Jürgen" last="Heinze">Jürgen Heinze</name><affiliation wicri:level="1"><nlm:aff id="I5">Biologie I, University of Regensburg, Universitätsstraße 31, 93040 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Biologie I, University of Regensburg, Universitätsstraße 31, 93040 Regensburg</wicri:regionArea><wicri:noRegion>93040 Regensburg</wicri:noRegion><wicri:noRegion>93040 Regensburg</wicri:noRegion><wicri:noRegion>93040 Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Burdach, Stefan" sort="Burdach, Stefan" uniqKey="Burdach S" first="Stefan" last="Burdach">Stefan Burdach</name><affiliation wicri:level="4"><nlm:aff id="I1">Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Laboratory of Functional Genomics and Transplantation Biology, Children's Cancer Research and Roman Herzog Comprehensive Cancer Center, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory of Functional Genomics and Transplantation Biology, Children's Cancer Research and Roman Herzog Comprehensive Cancer Center, Klinikum rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author></analytic><series><title level="j">Journal of Translational Medicine</title><idno type="eISSN">1479-5876</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."</p><p>Accordingly, we propose a model in which clonal expansion and cumulative acquisition of genetic alterations produce tumor compartments each equipped with distinct traits and thus distinct functions that cooperate to establish clinically apparent tumors. This functional compartment model also suggests mechanisms for the self-construction of tumor stem cell niches. Thus, thinking of a tumor as a superorganism will provide systemic insight into its functional compartmentalization and may even have clinical implications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maynard Smith, J" uniqKey="Maynard Smith J">J Maynard Smith</name></author><author><name sortKey="Szathmary, E" uniqKey="Szathmary E">E Szathmáry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourke, Afg" uniqKey="Bourke A">AFG Bourke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Queller, Dc" uniqKey="Queller D">DC Queller</name></author><author><name sortKey="Strassmann, Je" uniqKey="Strassmann J">JE Strassmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourke, A" uniqKey="Bourke A">A Bourke</name></author><author><name sortKey="Franks, N" uniqKey="Franks N">N 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Asgharzadeh</name></author><author><name sortKey="Seeger, Rc" uniqKey="Seeger R">RC Seeger</name></author><author><name sortKey="Messiaen, L" uniqKey="Messiaen L">L Messiaen</name></author><author><name sortKey="Versteeg, R" uniqKey="Versteeg R">R Versteeg</name></author><author><name sortKey="Bernards, R" uniqKey="Bernards R">R Bernards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sell, S" uniqKey="Sell S">S Sell</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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