Understanding tumor heterogeneity as functional compartments - superorganisms revisited
Identifieur interne : 002918 ( Main/Merge ); précédent : 002917; suivant : 002919Understanding tumor heterogeneity as functional compartments - superorganisms revisited
Auteurs : Thomas Gp Grunewald [Allemagne] ; Saskia M. Herbst [Allemagne] ; Jürgen Heinze [Allemagne] ; Stefan Burdach [Allemagne]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2011.
Abstract
Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."
Accordingly, we propose a model in which clonal expansion and cumulative acquisition of genetic alterations produce tumor compartments each equipped with distinct traits and thus distinct functions that cooperate to establish clinically apparent tumors. This functional compartment model also suggests mechanisms for the self-construction of tumor stem cell niches. Thus, thinking of a tumor as a superorganism will provide systemic insight into its functional compartmentalization and may even have clinical implications.
Url:
DOI: 10.1186/1479-5876-9-79
PubMed: 21619636
PubMed Central: 3118334
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PMC:3118334Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."</p>
<p>Accordingly, we propose a model in which clonal expansion and cumulative acquisition of genetic alterations produce tumor compartments each equipped with distinct traits and thus distinct functions that cooperate to establish clinically apparent tumors. This functional compartment model also suggests mechanisms for the self-construction of tumor stem cell niches. Thus, thinking of a tumor as a superorganism will provide systemic insight into its functional compartmentalization and may even have clinical implications.</p>
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