Population rate dynamics and multineuron firing patterns in sensory cortex
Identifieur interne : 002272 ( Main/Merge ); précédent : 002271; suivant : 002273Population rate dynamics and multineuron firing patterns in sensory cortex
Auteurs : Michael Okun [Royaume-Uni] ; Pierre Yger [Royaume-Uni] ; Stephan Marguet [États-Unis] ; Florian Gerard-Mercier [Royaume-Uni, France] ; Andrea Benucci [États-Unis] ; Steffen Katzner [États-Unis] ; Laura Busse [États-Unis] ; Matteo Carandini [Royaume-Uni, États-Unis] ; Kenneth D. Harris [Royaume-Uni, États-Unis]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 0270-6474 ] ; 2012.
Abstract
Cortical circuits encode sensory stimuli through the firing of neuronal ensembles, and also produce spontaneous population patterns in the absence of sensory drive. This population activity is often characterized experimentally by the distribution of multineuron “words” (binary firing vectors), and a match between spontaneous and evoked word distributions has been suggested to reflect learning of a probabilistic model of the sensory world. We analyzed multineuron word distributions in sensory cortex of anesthetized rats and cats, and found that they are dominated by fluctuations in population firing rate rather than precise interactions between individual units. Furthermore, cortical word distributions change when brain state shifts, and similar behavior is seen in simulated networks with fixed, random connectivity. Our results suggest that similarity or dissimilarity in multineuron word distributions could primarily reflect similarity or dissimilarity in population firing rate dynamics, and not necessarily the precise interactions between neurons that would indicate learning of sensory features.
Url:
DOI: 10.1523/JNEUROSCI.1831-12.2012
PubMed: 23197704
PubMed Central: 3520056
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and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName><orgName type="university">Université Rutgers</orgName></affiliation></author><author><name sortKey="Gerard Mercier, Florian" sort="Gerard Mercier, Florian" uniqKey="Gerard Mercier F" first="Florian" last="Gerard-Mercier">Florian Gerard-Mercier</name><affiliation wicri:level="1"><nlm:aff id="A1">Departments of Bioengineering, Electrical and Electronic Engineering, Imperial College, London SW7 2AZ, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Departments of Bioengineering, Electrical and Electronic Engineering, Imperial College, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">École Polytechnique, 91128 Palaiseau Cedex, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>École Polytechnique, 91128 Palaiseau Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Palaiseau</settlement></placeName></affiliation></author><author><name sortKey="Benucci, Andrea" sort="Benucci, Andrea" uniqKey="Benucci A" first="Andrea" last="Benucci">Andrea Benucci</name><affiliation wicri:level="2"><nlm:aff id="A5">Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Katzner, Steffen" sort="Katzner, Steffen" uniqKey="Katzner S" first="Steffen" last="Katzner">Steffen Katzner</name><affiliation wicri:level="2"><nlm:aff id="A5">Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Busse, Laura" sort="Busse, Laura" uniqKey="Busse L" first="Laura" last="Busse">Laura Busse</name><affiliation wicri:level="2"><nlm:aff id="A5">Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Carandini, Matteo" sort="Carandini, Matteo" uniqKey="Carandini M" first="Matteo" last="Carandini">Matteo Carandini</name><affiliation wicri:level="1"><nlm:aff id="A2">UCL Institute of Ophtalmology, University College London, 11–43 Bath Street, London EC1V 9EL, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophtalmology, University College London, 11–43 Bath Street, London EC1V 9EL</wicri:regionArea><wicri:noRegion>London EC1V 9EL</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A1">Departments of Bioengineering, Electrical and Electronic Engineering, Imperial College, London SW7 2AZ, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Departments of Bioengineering, Electrical and Electronic Engineering, Imperial College, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Kenneth D" sort="Harris, Kenneth D" uniqKey="Harris K" first="Kenneth D." last="Harris">Kenneth D. Harris</name><affiliation wicri:level="1"><nlm:aff id="A1">Departments of Bioengineering, Electrical and Electronic Engineering, Imperial College, London SW7 2AZ, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Departments of Bioengineering, Electrical and Electronic Engineering, Imperial College, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName><orgName type="university">Université Rutgers</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">UCL Institute of Ophtalmology, University College London, 11–43 Bath Street, London EC1V 9EL, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophtalmology, University College London, 11–43 Bath Street, London EC1V 9EL</wicri:regionArea><wicri:noRegion>London EC1V 9EL</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="ISSN">0270-6474</idno><idno type="eISSN">1529-2401</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cortical circuits encode sensory stimuli through the firing of neuronal ensembles, and also produce spontaneous population patterns in the absence of sensory drive. This population activity is often characterized experimentally by the distribution of multineuron “words” (binary firing vectors), and a match between spontaneous and evoked word distributions has been suggested to reflect learning of a probabilistic model of the sensory world. We analyzed multineuron word distributions in sensory cortex of anesthetized rats and cats, and found that they are dominated by fluctuations in population firing rate rather than precise interactions between individual units. Furthermore, cortical word distributions change when brain state shifts, and similar behavior is seen in simulated networks with fixed, random connectivity. Our results suggest that similarity or dissimilarity in multineuron word distributions could primarily reflect similarity or dissimilarity in population firing rate dynamics, and not necessarily the precise interactions between neurons that would indicate learning of sensory features.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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