The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions
Identifieur interne : 002140 ( Main/Merge ); précédent : 002139; suivant : 002141The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions
Auteurs : Markus Krieger [Allemagne] ; Martin Both [Allemagne] ; Simon A. Kranig [Allemagne] ; Claudia Pitzer [Allemagne] ; Matthias Klugmann [Australie] ; Gerhard Vogt [Allemagne] ; Andreas Draguhn [Allemagne] ; Armin Schneider [Allemagne]Source :
- Scientific Reports [ 2045-2322 ] ; 2012.
Abstract
We recently reported expression of hematopoietic growth factor GM-CSF and its receptor (GM-CSFR) in CNS neurons. Here we evaluated this system in learning and memory formation using GM-CSF deficient mice. In complementation, GM-CSF signalling was manipulated specifically in adult murine hippocampus by adeno-associated virus (AAV)-mediated GM-CSFR alpha overexpression or knock-down. GM-CSF ablation caused various hippocampus and amygdala-dependent deficits in spatial and fear memory while rendering intact basic parameters like motor function, inherent anxiety, and pain threshold levels. Corroborating these data, spatial memory of AAV-injected mice was positively correlated with GM-CSFRα expression levels. Hippocampal neurons of knock-out mice showed markedly pruned dendritic trees, reduced spine densities, and lower percentages of mature spines. Despite such morphological alterations, long-term potentiation (LTP) was unimpaired in the knock-out hippocampus. Collectively, these results suggest that GM-CSF signalling plays a major role in structural plasticity relevant to learning and memory.
Url:
DOI: 10.1038/srep00697
PubMed: 23019518
PubMed Central: 3458247
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PMC:3458247Le document en format XML
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Kranig</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Physiology, University of Heidelberg</institution>, Im Neuenheimer Feld 346, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pitzer, Claudia" sort="Pitzer, Claudia" uniqKey="Pitzer C" first="Claudia" last="Pitzer">Claudia Pitzer</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klugmann, Matthias" sort="Klugmann, Matthias" uniqKey="Klugmann M" first="Matthias" last="Klugmann">Matthias Klugmann</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales, UNSW Kensington Campus</institution>, Sydney, NSW, 2052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vogt, Gerhard" sort="Vogt, Gerhard" uniqKey="Vogt G" first="Gerhard" last="Vogt">Gerhard Vogt</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Draguhn, Andreas" sort="Draguhn, Andreas" uniqKey="Draguhn A" first="Andreas" last="Draguhn">Andreas Draguhn</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Physiology, University of Heidelberg</institution>, Im Neuenheimer Feld 346, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Armin" sort="Schneider, Armin" uniqKey="Schneider A" first="Armin" last="Schneider">Armin Schneider</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23019518</idno><idno type="pmc">3458247</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458247</idno><idno type="RBID">PMC:3458247</idno><idno type="doi">10.1038/srep00697</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000024</idno><idno type="wicri:Area/Pmc/Curation">000024</idno><idno type="wicri:Area/Pmc/Checkpoint">001521</idno><idno type="wicri:Area/Ncbi/Merge">002258</idno><idno type="wicri:Area/Ncbi/Curation">002258</idno><idno type="wicri:Area/Ncbi/Checkpoint">002258</idno><idno type="wicri:Area/Main/Merge">002140</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions</title><author><name sortKey="Krieger, Markus" sort="Krieger, Markus" uniqKey="Krieger M" first="Markus" last="Krieger">Markus Krieger</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Both, Martin" sort="Both, Martin" uniqKey="Both M" first="Martin" last="Both">Martin Both</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Physiology, University of Heidelberg</institution>, Im Neuenheimer Feld 346, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kranig, Simon A" sort="Kranig, Simon A" uniqKey="Kranig S" first="Simon A." last="Kranig">Simon A. Kranig</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Physiology, University of Heidelberg</institution>, Im Neuenheimer Feld 346, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pitzer, Claudia" sort="Pitzer, Claudia" uniqKey="Pitzer C" first="Claudia" last="Pitzer">Claudia Pitzer</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klugmann, Matthias" sort="Klugmann, Matthias" uniqKey="Klugmann M" first="Matthias" last="Klugmann">Matthias Klugmann</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales, UNSW Kensington Campus</institution>, Sydney, NSW, 2052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vogt, Gerhard" sort="Vogt, Gerhard" uniqKey="Vogt G" first="Gerhard" last="Vogt">Gerhard Vogt</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Draguhn, Andreas" sort="Draguhn, Andreas" uniqKey="Draguhn A" first="Andreas" last="Draguhn">Andreas Draguhn</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Physiology, University of Heidelberg</institution>, Im Neuenheimer Feld 346, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Armin" sort="Schneider, Armin" uniqKey="Schneider A" first="Armin" last="Schneider">Armin Schneider</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>SYGNIS Bioscience</institution>, Im Neuenheimer Feld 515, 69120 Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We recently reported expression of hematopoietic growth factor GM-CSF and its receptor (GM-CSFR) in CNS neurons. Here we evaluated this system in learning and memory formation using GM-CSF deficient mice. In complementation, GM-CSF signalling was manipulated specifically in adult murine hippocampus by adeno-associated virus (AAV)-mediated GM-CSFR alpha overexpression or knock-down. GM-CSF ablation caused various hippocampus and amygdala-dependent deficits in spatial and fear memory while rendering intact basic parameters like motor function, inherent anxiety, and pain threshold levels. Corroborating these data, spatial memory of AAV-injected mice was positively correlated with GM-CSFRα expression levels. Hippocampal neurons of knock-out mice showed markedly pruned dendritic trees, reduced spine densities, and lower percentages of mature spines. Despite such morphological alterations, long-term potentiation (LTP) was unimpaired in the knock-out hippocampus. Collectively, these results suggest that GM-CSF signalling plays a major role in structural plasticity relevant to learning and memory.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Armitage, J O" uniqKey="Armitage J">J. O. Armitage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Metcalf, D" uniqKey="Metcalf D">D. Metcalf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, G" uniqKey="Hansen G">G. Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, J" uniqKey="Baker J">J. Baker</name></author><author><name sortKey="Mccune, J S" uniqKey="Mccune J">J. S. McCune</name></author><author><name sortKey="Harvey, R D" uniqKey="Harvey R">R. D. Harvey</name></author><author><name sortKey="Bonsignore, C" uniqKey="Bonsignore C">C. Bonsignore</name></author><author><name sortKey="Lindley, C M" uniqKey="Lindley C">C. M. Lindley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Disis, M L" uniqKey="Disis M">M. L. Disis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korzenik, J R" uniqKey="Korzenik J">J. R. Korzenik</name></author><author><name sortKey="Dieckgraefe, B K" uniqKey="Dieckgraefe B">B. K. Dieckgraefe</name></author><author><name sortKey="Valentine, J F" uniqKey="Valentine J">J. F. Valentine</name></author><author><name sortKey="Hausman, D F" uniqKey="Hausman D">D. F. Hausman</name></author><author><name sortKey="Gilbert, M J" uniqKey="Gilbert M">M. J. Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schabitz, W R" uniqKey="Schabitz W">W. R. Schabitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kong, T" uniqKey="Kong T">T. Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakagawa, T" uniqKey="Nakagawa T">T. Nakagawa</name></author><author><name sortKey="Suga, S" uniqKey="Suga S">S. Suga</name></author><author><name sortKey="Kawase, T" uniqKey="Kawase T">T. Kawase</name></author><author><name sortKey="Toda, M" uniqKey="Toda M">M. Toda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, N K" uniqKey="Kim N">N. K. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruger, C" uniqKey="Kruger C">C. Kruger</name></author><author><name sortKey="Laage, R" uniqKey="Laage R">R. Laage</name></author><author><name sortKey="Pitzer, C" uniqKey="Pitzer C">C. Pitzer</name></author><author><name sortKey="Schabitz, W R" uniqKey="Schabitz W">W. R. Schabitz</name></author><author><name sortKey="Schneider, A" uniqKey="Schneider A">A. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, J A" uniqKey="Reed J">J. A. Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maurer, M H" uniqKey="Maurer M">M. H. Maurer</name></author><author><name sortKey="Schabitz, W R" uniqKey="Schabitz W">W. R. Schabitz</name></author><author><name sortKey="Schneider, A" uniqKey="Schneider A">A. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mclay, R N" uniqKey="Mclay R">R. N. McLay</name></author><author><name sortKey="Banks, W A" uniqKey="Banks W">W. A. Banks</name></author><author><name sortKey="Kastin, A J" uniqKey="Kastin A">A. J. Kastin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aboulkassim, T" uniqKey="Aboulkassim T">T. Aboulkassim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bekinschtein, P" uniqKey="Bekinschtein P">P. Bekinschtein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dranoff, G" uniqKey="Dranoff G">G. Dranoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, E K" uniqKey="Weiss E">E. K. Weiss</name></author><author><name sortKey="Krupka, N" uniqKey="Krupka N">N. Krupka</name></author><author><name sortKey="Bahner, F" uniqKey="Bahner F">F. Bahner</name></author><author><name sortKey="Both, M" uniqKey="Both M">M. Both</name></author><author><name sortKey="Draguhn, A" uniqKey="Draguhn A">A. Draguhn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuzaki, M" uniqKey="Matsuzaki M">M. Matsuzaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author><author><name sortKey="Zhang, M X" uniqKey="Zhang M">M. X. Zhang</name></author><author><name sortKey="Swank, M W" uniqKey="Swank M">M. W. Swank</name></author><author><name sortKey="Kunz, J" uniqKey="Kunz J">J. Kunz</name></author><author><name sortKey="Wu, G Y" uniqKey="Wu G">G. Y. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jan, Y N" uniqKey="Jan Y">Y. N. Jan</name></author><author><name sortKey="Jan, L Y" uniqKey="Jan L">L. Y. Jan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaworski, J" uniqKey="Jaworski J">J. Jaworski</name></author><author><name sortKey="Spangler, S" uniqKey="Spangler S">S. Spangler</name></author><author><name sortKey="Seeburg, D P" uniqKey="Seeburg D">D. P. Seeburg</name></author><author><name sortKey="Hoogenraad, C C" uniqKey="Hoogenraad C">C. C. Hoogenraad</name></author><author><name sortKey="Sheng, M" uniqKey="Sheng M">M. Sheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neves, G" uniqKey="Neves G">G. Neves</name></author><author><name sortKey="Cooke, S F" uniqKey="Cooke S">S. F. Cooke</name></author><author><name sortKey="Bliss, T V" uniqKey="Bliss T">T. V. Bliss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M H" uniqKey="Kim M">M. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Migaud, M" uniqKey="Migaud M">M. Migaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rutten, K" uniqKey="Rutten K">K. Rutten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Digicaylioglu, M" uniqKey="Digicaylioglu M">M. Digicaylioglu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, A" uniqKey="Schneider A">A. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diederich, K" uniqKey="Diederich K">K. Diederich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diederich, K" uniqKey="Diederich K">K. Diederich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adamcio, B" uniqKey="Adamcio B">B. Adamcio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Kordi, A" uniqKey="El Kordi A">A. El-Kordi</name></author><author><name sortKey="Radyushkin, K" uniqKey="Radyushkin K">K. Radyushkin</name></author><author><name sortKey="Ehrenreich, H" uniqKey="Ehrenreich H">H. Ehrenreich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sargin, D" uniqKey="Sargin D">D. Sargin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehrenreich, H" uniqKey="Ehrenreich H">H. Ehrenreich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehrenreich, H" uniqKey="Ehrenreich H">H. Ehrenreich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsh, J T" uniqKey="Marsh J">J. T. Marsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korte, M" uniqKey="Korte M">M. Korte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korte, M" uniqKey="Korte M">M. Korte</name></author><author><name sortKey="Kang, H" uniqKey="Kang H">H. Kang</name></author><author><name sortKey="Bonhoeffer, T" uniqKey="Bonhoeffer T">T. Bonhoeffer</name></author><author><name sortKey="Schuman, E" uniqKey="Schuman E">E. Schuman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bianchi, M" uniqKey="Bianchi M">M. Bianchi</name></author><author><name sortKey="Sacerdote, P" uniqKey="Sacerdote P">P. Sacerdote</name></author><author><name sortKey="Panerai, A E" uniqKey="Panerai A">A. E. Panerai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyd, T D" uniqKey="Boyd T">T. D. Boyd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berclaz, P Y" uniqKey="Berclaz P">P. Y. Berclaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levine, A M" uniqKey="Levine A">A. M. LeVine</name></author><author><name sortKey="Reed, J A" uniqKey="Reed J">J. A. Reed</name></author><author><name sortKey="Kurak, K E" uniqKey="Kurak K">K. E. Kurak</name></author><author><name sortKey="Cianciolo, E" uniqKey="Cianciolo E">E. Cianciolo</name></author><author><name sortKey="Whitsett, J A" uniqKey="Whitsett J">J. A. Whitsett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M. Yoshida</name></author><author><name sortKey="Ikegami, M" uniqKey="Ikegami M">M. Ikegami</name></author><author><name sortKey="Reed, J A" uniqKey="Reed J">J. A. Reed</name></author><author><name sortKey="Chroneos, Z C" uniqKey="Chroneos Z">Z. C. Chroneos</name></author><author><name sortKey="Whitsett, J A" uniqKey="Whitsett J">J. A. Whitsett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franich, N R" uniqKey="Franich N">N. R. Franich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, Y" uniqKey="Zeng Y">Y. Zeng</name></author><author><name sortKey="Cullen, B R" uniqKey="Cullen B">B. R. Cullen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, N" uniqKey="Yang N">N. Yang</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Kazazian, H H" uniqKey="Kazazian H">H. H. Kazazian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klugmann, M" uniqKey="Klugmann M">M. Klugmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G. Paxinos</name></author><author><name sortKey="Franklin, K B J" uniqKey="Franklin K">K. B. J. Franklin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano, P" uniqKey="Serrano P">P. Serrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehninger, D" uniqKey="Ehninger D">D. Ehninger</name></author><author><name sortKey="Kempermann, G" uniqKey="Kempermann G">G. Kempermann</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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