Frequency representation within the human brain: Stability versus plasticity
Identifieur interne : 001B84 ( Main/Merge ); précédent : 001B83; suivant : 001B85Frequency representation within the human brain: Stability versus plasticity
Auteurs : Hubert H. Lim [États-Unis] ; Minoo Lenarz [Allemagne] ; Gert Joseph [Allemagne] ; Thomas Lenarz [Allemagne]Source :
- Scientific Reports [ 2045-2322 ] ; 2013.
Abstract
A topographical representation for frequency has been identified throughout the auditory brain in animals but with limited evidence in humans. Using a midbrain implant, we identified an ordering of pitch percepts for electrical stimulation of sites across the human inferior colliculus (IC) that was consistent with the IC tonotopy shown in animals. Low pitches were perceived by the subject for stimulation of superficial IC sites while higher pitches were perceived for stimulation of deeper sites. Interestingly, this pitch ordering was not initially observed for stimulation across the IC, possibly due to central changes caused by prior hearing loss. Daily implant stimulation for about 4 months altered the pitch percepts from being predominantly low to exhibiting the expected ordering across the stimulated IC. A presumably normal tonotopic representation may have been maintained within the IC or accessible through IC stimulation that helped form this pitch ordering perceived in higher centers.
Url:
DOI: 10.1038/srep01474
PubMed: 23502431
PubMed Central: 3600597
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Lim</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, University of Minnesota</institution>, Minneapolis, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Translational Neuroscience, University of Minnesota</institution>, Minneapolis, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lenarz, Minoo" sort="Lenarz, Minoo" uniqKey="Lenarz M" first="Minoo" last="Lenarz">Minoo Lenarz</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Otolaryngology, Berlin University – Charite</institution>, Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joseph, Gert" sort="Joseph, Gert" uniqKey="Joseph G" first="Gert" last="Joseph">Gert Joseph</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Otolaryngology, Hannover Medical University</institution>, Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lenarz, Thomas" sort="Lenarz, Thomas" uniqKey="Lenarz T" first="Thomas" last="Lenarz">Thomas Lenarz</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Otolaryngology, Hannover Medical University</institution>, Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23502431</idno><idno type="pmc">3600597</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600597</idno><idno type="RBID">PMC:3600597</idno><idno type="doi">10.1038/srep01474</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000025</idno><idno type="wicri:Area/Pmc/Curation">000025</idno><idno type="wicri:Area/Pmc/Checkpoint">001246</idno><idno type="wicri:Area/Ncbi/Merge">002571</idno><idno type="wicri:Area/Ncbi/Curation">002571</idno><idno type="wicri:Area/Ncbi/Checkpoint">002571</idno><idno type="wicri:Area/Main/Merge">001B84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Frequency representation within the human brain: Stability versus plasticity</title><author><name sortKey="Lim, Hubert H" sort="Lim, Hubert H" uniqKey="Lim H" first="Hubert H." last="Lim">Hubert H. Lim</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, University of Minnesota</institution>, Minneapolis, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute for Translational Neuroscience, University of Minnesota</institution>, Minneapolis, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lenarz, Minoo" sort="Lenarz, Minoo" uniqKey="Lenarz M" first="Minoo" last="Lenarz">Minoo Lenarz</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Otolaryngology, Berlin University – Charite</institution>, Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joseph, Gert" sort="Joseph, Gert" uniqKey="Joseph G" first="Gert" last="Joseph">Gert Joseph</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Otolaryngology, Hannover Medical University</institution>, Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lenarz, Thomas" sort="Lenarz, Thomas" uniqKey="Lenarz T" first="Thomas" last="Lenarz">Thomas Lenarz</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Otolaryngology, Hannover Medical University</institution>, Hannover,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A topographical representation for frequency has been identified throughout the auditory brain in animals but with limited evidence in humans. Using a midbrain implant, we identified an ordering of pitch percepts for electrical stimulation of sites across the human inferior colliculus (IC) that was consistent with the IC tonotopy shown in animals. Low pitches were perceived by the subject for stimulation of superficial IC sites while higher pitches were perceived for stimulation of deeper sites. Interestingly, this pitch ordering was not initially observed for stimulation across the IC, possibly due to central changes caused by prior hearing loss. Daily implant stimulation for about 4 months altered the pitch percepts from being predominantly low to exhibiting the expected ordering across the stimulated IC. A presumably normal tonotopic representation may have been maintained within the IC or accessible through IC stimulation that helped form this pitch ordering perceived in higher centers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Levelt, C N" uniqKey="Levelt C">C. N. Levelt</name></author><author><name sortKey="Hubener, M" uniqKey="Hubener M">M. Hubener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Villers Sidani, E" uniqKey="De Villers Sidani E">E. de Villers-Sidani</name></author><author><name sortKey="Merzenich, M M" uniqKey="Merzenich M">M. M. Merzenich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, E G" uniqKey="Jones E">E. G. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fallon, J B" uniqKey="Fallon J">J. B. Fallon</name></author><author><name sortKey="Irvine, D R" uniqKey="Irvine D">D. R. 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Patrick</name></author><author><name sortKey="Busby, P A" uniqKey="Busby P">P. A. Busby</name></author><author><name sortKey="Gibson, P J" uniqKey="Gibson P">P. J. Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruxton, G D" uniqKey="Ruxton G">G. D. Ruxton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lenarz, T" uniqKey="Lenarz T">T. Lenarz</name></author><author><name sortKey="Lim, H H" uniqKey="Lim H">H. H. Lim</name></author><author><name sortKey="Reuter, G" uniqKey="Reuter G">G. Reuter</name></author><author><name sortKey="Patrick, J F" uniqKey="Patrick J">J. F. Patrick</name></author><author><name sortKey="Lenarz, M" uniqKey="Lenarz M">M. Lenarz</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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