Integration of Sensory Force Feedback Is Disturbed in CRPS-Related Dystonia
Identifieur interne : 001B04 ( Main/Merge ); précédent : 001B03; suivant : 001B05Integration of Sensory Force Feedback Is Disturbed in CRPS-Related Dystonia
Auteurs : Winfred Mugge [Pays-Bas] ; Frans C. T. Van Der Helm [Pays-Bas, États-Unis] ; Alfred C. Schouten [Pays-Bas]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system to improve the state estimate. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback. The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia weight force and position feedback differently than controls do. The study shows reduced force feedback weights in CRPS-patients with fixed dystonia, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.
Url:
DOI: 10.1371/journal.pone.0060293
PubMed: 23555946
PubMed Central: 3608579
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T." last="Van Der Helm">Frans C. T. Van Der Helm</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of BioMechanical Engineering, Delft University of Technology, Delft</wicri:regionArea><wicri:noRegion>Delft</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Schouten, Alfred C" sort="Schouten, Alfred C" uniqKey="Schouten A" first="Alfred C." last="Schouten">Alfred C. Schouten</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of BioMechanical Engineering, Delft University of Technology, Delft</wicri:regionArea><wicri:noRegion>Delft</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Laboratory of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede</wicri:regionArea><orgName type="university">Université de Twente</orgName><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system to improve the state estimate. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback. The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia weight force and position feedback differently than controls do. The study shows reduced force feedback weights in CRPS-patients with fixed dystonia, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kording, Kp" uniqKey="Kording K">KP Körding</name></author><author><name sortKey="Ku, Sp" uniqKey="Ku S">SP Ku</name></author><author><name sortKey="Wolpert, Dm" uniqKey="Wolpert D">DM Wolpert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kording, Kp" uniqKey="Kording K">KP Körding</name></author><author><name sortKey="Wolpert, Dm" uniqKey="Wolpert D">DM Wolpert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ernst, Mo" uniqKey="Ernst M">MO Ernst</name></author><author><name sortKey="Bulthoff, Hh" uniqKey="Bulthoff H">HH 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