Patient DF's visual brain in action: Visual feedforward control in visual form agnosia.
Identifieur interne : 000675 ( Main/Merge ); précédent : 000674; suivant : 000676Patient DF's visual brain in action: Visual feedforward control in visual form agnosia.
Auteurs : Robert L. Whitwell [Canada] ; A David Milner [Royaume-Uni] ; Cristiana Cavina-Pratesi [Royaume-Uni] ; Masihullah Barat [Canada] ; Melvyn A. Goodale [Canada]Source :
- Vision research [ 1878-5646 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Agnosia (physiopathology), Analysis of Variance, Carbon Monoxide Poisoning (physiopathology), Feedback, Sensory (physiology), Female, Hand (physiology), Humans, Male, Middle Aged, Movement (physiology), Psychomotor Performance (physiology), Vision Disorders (physiopathology), Visual Perception (physiology).
- MESH :
- physiology : Feedback, Sensory, Hand, Movement, Psychomotor Performance, Visual Perception.
- physiopathology : Agnosia, Carbon Monoxide Poisoning, Vision Disorders.
- Aged, Analysis of Variance, Female, Humans, Male, Middle Aged.
Abstract
Patient DF, who developed visual form agnosia following ventral-stream damage, is unable to discriminate the width of objects, performing at chance, for example, when asked to open her thumb and forefinger a matching amount. Remarkably, however, DF adjusts her hand aperture to accommodate the width of objects when reaching out to pick them up (grip scaling). While this spared ability to grasp objects is presumed to be mediated by visuomotor modules in her relatively intact dorsal stream, it is possible that it may rely abnormally on online visual or haptic feedback. We report here that DF's grip scaling remained intact when her vision was completely suppressed during grasp movements, and it still dissociated sharply from her poor perceptual estimates of target size. We then tested whether providing trial-by-trial haptic feedback after making such perceptual estimates might improve DF's performance, but found that they remained significantly impaired. In a final experiment, we re-examined whether DF's grip scaling depends on receiving veridical haptic feedback during grasping. In one condition, the haptic feedback was identical to the visual targets. In a second condition, the haptic feedback was of a constant intermediate width while the visual target varied trial by trial. Despite this incongruent feedback, DF still scaled her grip aperture to the visual widths of the target blocks, showing only normal adaptation to the false haptically-experienced width. Taken together, these results strengthen the view that DF's spared grasping relies on a normal mode of dorsal-stream functioning, based chiefly on visual feedforward processing.
DOI: 10.1016/j.visres.2014.08.016
PubMed: 25199609
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pubmed:25199609Le document en format XML
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Electronic address: rwhitwel@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7, Canada; The Graduate Program in Neuroscience, The University of Western Ontario, London, Ontario N6A 5B7</wicri:regionArea><wicri:noRegion>Ontario N6A 5B7</wicri:noRegion></affiliation></author><author><name sortKey="Milner, A David" sort="Milner, A David" uniqKey="Milner A" first="A David" last="Milner">A David Milner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Durham University, South Road, DH1 3LE Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, Durham University, South Road, DH1 3LE Durham</wicri:regionArea><wicri:noRegion>DH1 3LE Durham</wicri:noRegion></affiliation></author><author><name sortKey="Cavina Pratesi, Cristiana" sort="Cavina Pratesi, Cristiana" uniqKey="Cavina Pratesi C" first="Cristiana" last="Cavina-Pratesi">Cristiana Cavina-Pratesi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Durham University, South Road, DH1 3LE Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, Durham University, South Road, DH1 3LE Durham</wicri:regionArea><wicri:noRegion>DH1 3LE Durham</wicri:noRegion></affiliation></author><author><name sortKey="Barat, Masihullah" sort="Barat, Masihullah" uniqKey="Barat M" first="Masihullah" last="Barat">Masihullah Barat</name><affiliation wicri:level="1"><nlm:affiliation>Undergraduate Program in Physiology and Pharmacology, The University of Western Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Undergraduate Program in Physiology and Pharmacology, The University of Western Ontario</wicri:regionArea><wicri:noRegion>The University of Western Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Goodale, Melvyn A" sort="Goodale, Melvyn A" uniqKey="Goodale M" first="Melvyn A" last="Goodale">Melvyn A. Goodale</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7</wicri:regionArea><wicri:noRegion>Ontario N6A 5B7</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25199609</idno><idno type="pmid">25199609</idno><idno type="doi">10.1016/j.visres.2014.08.016</idno><idno type="wicri:Area/PubMed/Corpus">000558</idno><idno type="wicri:Area/PubMed/Curation">000558</idno><idno type="wicri:Area/PubMed/Checkpoint">000279</idno><idno type="wicri:Area/Ncbi/Merge">003273</idno><idno type="wicri:Area/Ncbi/Curation">003273</idno><idno type="wicri:Area/Ncbi/Checkpoint">003273</idno><idno type="wicri:Area/Main/Merge">000675</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patient DF's visual brain in action: Visual feedforward control in visual form agnosia.</title><author><name sortKey="Whitwell, Robert L" sort="Whitwell, Robert L" uniqKey="Whitwell R" first="Robert L" last="Whitwell">Robert L. Whitwell</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7, Canada; The Graduate Program in Neuroscience, The University of Western Ontario, London, Ontario N6A 5B7, Canada. Electronic address: rwhitwel@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7, Canada; The Graduate Program in Neuroscience, The University of Western Ontario, London, Ontario N6A 5B7</wicri:regionArea><wicri:noRegion>Ontario N6A 5B7</wicri:noRegion></affiliation></author><author><name sortKey="Milner, A David" sort="Milner, A David" uniqKey="Milner A" first="A David" last="Milner">A David Milner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Durham University, South Road, DH1 3LE Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, Durham University, South Road, DH1 3LE Durham</wicri:regionArea><wicri:noRegion>DH1 3LE Durham</wicri:noRegion></affiliation></author><author><name sortKey="Cavina Pratesi, Cristiana" sort="Cavina Pratesi, Cristiana" uniqKey="Cavina Pratesi C" first="Cristiana" last="Cavina-Pratesi">Cristiana Cavina-Pratesi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Durham University, South Road, DH1 3LE Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, Durham University, South Road, DH1 3LE Durham</wicri:regionArea><wicri:noRegion>DH1 3LE Durham</wicri:noRegion></affiliation></author><author><name sortKey="Barat, Masihullah" sort="Barat, Masihullah" uniqKey="Barat M" first="Masihullah" last="Barat">Masihullah Barat</name><affiliation wicri:level="1"><nlm:affiliation>Undergraduate Program in Physiology and Pharmacology, The University of Western Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Undergraduate Program in Physiology and Pharmacology, The University of Western Ontario</wicri:regionArea><wicri:noRegion>The University of Western Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Goodale, Melvyn A" sort="Goodale, Melvyn A" uniqKey="Goodale M" first="Melvyn A" last="Goodale">Melvyn A. Goodale</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, The University of Western Ontario, London, Ontario N6A 5B7</wicri:regionArea><wicri:noRegion>Ontario N6A 5B7</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vision research</title><idno type="eISSN">1878-5646</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Agnosia (physiopathology)</term><term>Analysis of Variance</term><term>Carbon Monoxide Poisoning (physiopathology)</term><term>Feedback, Sensory (physiology)</term><term>Female</term><term>Hand (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Vision Disorders (physiopathology)</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Feedback, Sensory</term><term>Hand</term><term>Movement</term><term>Psychomotor Performance</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Agnosia</term><term>Carbon Monoxide Poisoning</term><term>Vision Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patient DF, who developed visual form agnosia following ventral-stream damage, is unable to discriminate the width of objects, performing at chance, for example, when asked to open her thumb and forefinger a matching amount. Remarkably, however, DF adjusts her hand aperture to accommodate the width of objects when reaching out to pick them up (grip scaling). While this spared ability to grasp objects is presumed to be mediated by visuomotor modules in her relatively intact dorsal stream, it is possible that it may rely abnormally on online visual or haptic feedback. We report here that DF's grip scaling remained intact when her vision was completely suppressed during grasp movements, and it still dissociated sharply from her poor perceptual estimates of target size. We then tested whether providing trial-by-trial haptic feedback after making such perceptual estimates might improve DF's performance, but found that they remained significantly impaired. In a final experiment, we re-examined whether DF's grip scaling depends on receiving veridical haptic feedback during grasping. In one condition, the haptic feedback was identical to the visual targets. In a second condition, the haptic feedback was of a constant intermediate width while the visual target varied trial by trial. Despite this incongruent feedback, DF still scaled her grip aperture to the visual widths of the target blocks, showing only normal adaptation to the false haptically-experienced width. Taken together, these results strengthen the view that DF's spared grasping relies on a normal mode of dorsal-stream functioning, based chiefly on visual feedforward processing.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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