An Optical Section-Assisted In Vivo Rabbit Model for Capsular Bend and Posterior Capsule Opacification Investigation
Identifieur interne : 000292 ( Main/Exploration ); précédent : 000291; suivant : 000293An Optical Section-Assisted In Vivo Rabbit Model for Capsular Bend and Posterior Capsule Opacification Investigation
Auteurs : Pingjun Chang ; Lei Lin ; Qian Zheng ; Fang Yu ; Xiaoyu Yu ; Yinying Zhao ; Xixia Ding ; Weigen Zhu ; Jin Li ; Yun-E ZhaoSource :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
To establish an optical section-assisted in vivo rabbit model for capsular bend and posterior capsule opacification (PCO) investigation.
A total of 10 rabbits underwent phacoemulsification surgery and intraocular lens (IOL) implantation. On the basis of the relationship between the anterior capsule and IOL, the rabbits were divided into complete overlap and incomplete overlap groups, in which six and four rabbits were included, respectively. The capsular bend optical sections were assessed using ultra-long scan depth optical coherence tomography (UL-OCT), and posterior capsule opacification was evaluated with slit lamp on postoperative day 3, 7, 14, and 28. In addition, histopathological section was used to verify the accuracy of capsular bend type captured by OCT in three rabbits.
Based on the special animal model, six capsular bend types were observed, namely, anterior (A), middle (M), posterior (P), detachment (D), funnel (Fun) and furcate adhesion (Fur). On day 3, capsular bend began to form. On 14 days, the capsular bends were comprised of A, M and D types, which were almost maintained until day 28. Histopathological section findings were consistent with optical sectioning results. In the incomplete and complete groups, the earliest PCO within the optical zone were on day 7 and 28, respectively. The incomplete group exhibited higher incidence and faster PCO on day 7 (p = 0.038) and 14 (p = 0.002).
This animal model not only mimics capsular bend evolution and PCO processes but also produces OCT optical section images equivalent to and more repeatable than histopathology, thereby providing a promising method for the further investigations of PCO.
Url:
DOI: 10.1371/journal.pone.0148553
PubMed: 26840405
PubMed Central: 4739694
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Optical Section-Assisted <italic>In Vivo</italic> Rabbit Model for Capsular Bend and Posterior Capsule Opacification Investigation</title><author><name sortKey="Chang, Pingjun" sort="Chang, Pingjun" uniqKey="Chang P" first="Pingjun" last="Chang">Pingjun Chang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Lin, Lei" sort="Lin, Lei" uniqKey="Lin L" first="Lei" last="Lin">Lei Lin</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zheng, Qian" sort="Zheng, Qian" uniqKey="Zheng Q" first="Qian" last="Zheng">Qian Zheng</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Fang" sort="Yu, Fang" uniqKey="Yu F" first="Fang" last="Yu">Fang Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Xiaoyu" sort="Yu, Xiaoyu" uniqKey="Yu X" first="Xiaoyu" last="Yu">Xiaoyu Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Yinying" sort="Zhao, Yinying" uniqKey="Zhao Y" first="Yinying" last="Zhao">Yinying Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Ding, Xixia" sort="Ding, Xixia" uniqKey="Ding X" first="Xixia" last="Ding">Xixia Ding</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Weigen" sort="Zhu, Weigen" uniqKey="Zhu W" first="Weigen" last="Zhu">Weigen Zhu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Li, Jin" sort="Li, Jin" uniqKey="Li J" first="Jin" last="Li">Jin Li</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Yun E" sort="Zhao, Yun E" uniqKey="Zhao Y" first="Yun-E" last="Zhao">Yun-E Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26840405</idno><idno type="pmc">4739694</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739694</idno><idno type="RBID">PMC:4739694</idno><idno type="doi">10.1371/journal.pone.0148553</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000546</idno><idno type="wicri:Area/Pmc/Curation">000546</idno><idno type="wicri:Area/Pmc/Checkpoint">000165</idno><idno type="wicri:Area/Ncbi/Merge">003F57</idno><idno type="wicri:Area/Ncbi/Curation">003F57</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F57</idno><idno type="wicri:Area/Main/Merge">000292</idno><idno type="wicri:Area/Main/Curation">000292</idno><idno type="wicri:Area/Main/Exploration">000292</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An Optical Section-Assisted <italic>In Vivo</italic> Rabbit Model for Capsular Bend and Posterior Capsule Opacification Investigation</title><author><name sortKey="Chang, Pingjun" sort="Chang, Pingjun" uniqKey="Chang P" first="Pingjun" last="Chang">Pingjun Chang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Lin, Lei" sort="Lin, Lei" uniqKey="Lin L" first="Lei" last="Lin">Lei Lin</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zheng, Qian" sort="Zheng, Qian" uniqKey="Zheng Q" first="Qian" last="Zheng">Qian Zheng</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Fang" sort="Yu, Fang" uniqKey="Yu F" first="Fang" last="Yu">Fang Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Xiaoyu" sort="Yu, Xiaoyu" uniqKey="Yu X" first="Xiaoyu" last="Yu">Xiaoyu Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Yinying" sort="Zhao, Yinying" uniqKey="Zhao Y" first="Yinying" last="Zhao">Yinying Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Ding, Xixia" sort="Ding, Xixia" uniqKey="Ding X" first="Xixia" last="Ding">Xixia Ding</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Weigen" sort="Zhu, Weigen" uniqKey="Zhu W" first="Weigen" last="Zhu">Weigen Zhu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Li, Jin" sort="Li, Jin" uniqKey="Li J" first="Jin" last="Li">Jin Li</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Yun E" sort="Zhao, Yun E" uniqKey="Zhao Y" first="Yun-E" last="Zhao">Yun-E Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Purpose</title><p>To establish an optical section-assisted in vivo rabbit model for capsular bend and posterior capsule opacification (PCO) investigation.</p></sec><sec id="sec002"><title>Methods</title><p>A total of 10 rabbits underwent phacoemulsification surgery and intraocular lens (IOL) implantation. On the basis of the relationship between the anterior capsule and IOL, the rabbits were divided into complete overlap and incomplete overlap groups, in which six and four rabbits were included, respectively. The capsular bend optical sections were assessed using ultra-long scan depth optical coherence tomography (UL-OCT), and posterior capsule opacification was evaluated with slit lamp on postoperative day 3, 7, 14, and 28. In addition, histopathological section was used to verify the accuracy of capsular bend type captured by OCT in three rabbits.</p></sec><sec id="sec003"><title>Results</title><p>Based on the special animal model, six capsular bend types were observed, namely, anterior (A), middle (M), posterior (P), detachment (D), funnel (Fun) and furcate adhesion (Fur). On day 3, capsular bend began to form. On 14 days, the capsular bends were comprised of A, M and D types, which were almost maintained until day 28. Histopathological section findings were consistent with optical sectioning results. In the incomplete and complete groups, the earliest PCO within the optical zone were on day 7 and 28, respectively. The incomplete group exhibited higher incidence and faster PCO on day 7 (p = 0.038) and 14 (p = 0.002).</p></sec><sec id="sec004"><title>Conclusions</title><p>This animal model not only mimics capsular bend evolution and PCO processes but also produces OCT optical section images equivalent to and more repeatable than histopathology, thereby providing a promising method for the further investigations of PCO.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Knight Nanan, D" uniqKey="Knight Nanan D">D Knight-Nanan</name></author><author><name sortKey="O Keefe, M" uniqKey="O Keefe M">M O'Keefe</name></author><author><name sortKey="Bowell, R" uniqKey="Bowell R">R Bowell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacu, S" uniqKey="Sacu S">S Sacu</name></author><author><name sortKey="Findl, O" uniqKey="Findl O">O Findl</name></author><author><name sortKey="Menapace, R" uniqKey="Menapace R">R 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last="Lin">Lei Lin</name><name sortKey="Yu, Fang" sort="Yu, Fang" uniqKey="Yu F" first="Fang" last="Yu">Fang Yu</name><name sortKey="Yu, Xiaoyu" sort="Yu, Xiaoyu" uniqKey="Yu X" first="Xiaoyu" last="Yu">Xiaoyu Yu</name><name sortKey="Zhao, Yinying" sort="Zhao, Yinying" uniqKey="Zhao Y" first="Yinying" last="Zhao">Yinying Zhao</name><name sortKey="Zhao, Yun E" sort="Zhao, Yun E" uniqKey="Zhao Y" first="Yun-E" last="Zhao">Yun-E Zhao</name><name sortKey="Zheng, Qian" sort="Zheng, Qian" uniqKey="Zheng Q" first="Qian" last="Zheng">Qian Zheng</name><name sortKey="Zhu, Weigen" sort="Zhu, Weigen" uniqKey="Zhu W" first="Weigen" last="Zhu">Weigen Zhu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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