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Flow of cortical activity underlying a tactile decision in mice

Identifieur interne : 001B79 ( Main/Exploration ); précédent : 001B78; suivant : 001B80

Flow of cortical activity underlying a tactile decision in mice

Auteurs : Zengcai V. Guo [États-Unis] ; Nuo Li [États-Unis] ; Daniel Huber [États-Unis] ; Eran Ophir [États-Unis] ; Diego Gutnisky [États-Unis] ; Jonathan T. Ting [États-Unis] ; Guoping Feng [États-Unis] ; Karel Svoboda [États-Unis]

Source :

Neuron [ 0896-6273 ] ; 2013.

RBID : PMC:3984938

Abstract

Summary

Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile “sensation” and “action” (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms) we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984938

DOI: 10.1016/j.neuron.2013.10.020
PubMed: 24361077
PubMed Central: 3984938

Affiliations:

Le document en format XML

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Serveur d'exploration sur les dispositifs haptiques

Flow of cortical activity underlying a tactile decision in mice

Flow of cortical activity underlying a tactile decision in mice

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Abstract

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