Neuropsychological effects of irradiation and chemotherapy treatments upon children with acute lymphoblastic leukemia: a case study of monozygotic twins.
Identifieur interne : 009948 ( Main/Exploration ); précédent : 009947; suivant : 009949Neuropsychological effects of irradiation and chemotherapy treatments upon children with acute lymphoblastic leukemia: a case study of monozygotic twins.
Auteurs : M T Prince ; G T Souheaver ; D H BerrySource :
- Neurotoxicology [ 0161-813X ] ; 1988.
English descriptors
- KwdEn :
- Adolescent, Cognition (drug effects), Cognition (radiation effects), Combined Modality Therapy, Diseases in Twins, Female, Follow-Up Studies, Humans, Intelligence Tests, Methotrexate (adverse effects), Precursor Cell Lymphoblastic Leukemia-Lymphoma (psychology), Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy), Radiation Injuries (psychology), Twins, Twins, Monozygotic.
- MESH :
- chemical , adverse effects : Methotrexate.
- drug effects : Cognition.
- psychology : Precursor Cell Lymphoblastic Leukemia-Lymphoma, Radiation Injuries.
- radiation effects : Cognition.
- therapy : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- Adolescent, Combined Modality Therapy, Diseases in Twins, Female, Follow-Up Studies, Humans, Intelligence Tests, Twins, Twins, Monozygotic.
Abstract
Numerous attempts have been made to determine the effects of irradiation and chemotherapy upon cognitive functioning when used for treatment of acute lymphoblastic leukemia (ALL). While many studies have demonstrated a deleterious effect, others have found no significant changes in neuropsychological functioning. The uncertainty regarding the cognitive effects of these treatments is exemplified via a presentation of monozygotic twins who were evaluated via neuropsychological tests. The children received similar induction-consolidation therapy which included intrathecal methotrexate and cranial irradiation. Neuropsychological tests yielded almost identical I.Q. patterns, however, subtle differences were noted between the children when abstract reasoning abilities, achievement tests scores, motor speed, grip strength, performance on complex tasks requiring haptic sensitivity, and fingertip sensitivity were observed. This discussion also summarizes the previous findings related to cognitive function after chemotherapy and radiation therapy and some of the confounding factors which have been noted.
PubMed: 3200503
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuropsychological effects of irradiation and chemotherapy treatments upon children with acute lymphoblastic leukemia: a case study of monozygotic twins.</title><author><name sortKey="Prince, M T" sort="Prince, M T" uniqKey="Prince M" first="M T" last="Prince">M T Prince</name><affiliation><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72205.</nlm:affiliation><wicri:noCountry code="subField">Little Rock 72205</wicri:noCountry></affiliation></author><author><name sortKey="Souheaver, G T" sort="Souheaver, G T" uniqKey="Souheaver G" first="G T" last="Souheaver">G T Souheaver</name></author><author><name sortKey="Berry, D H" sort="Berry, D H" uniqKey="Berry D" first="D H" last="Berry">D H Berry</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1988">1988</date><idno type="RBID">pubmed:3200503</idno><idno type="pmid">3200503</idno><idno type="wicri:Area/PubMed/Corpus">002298</idno><idno type="wicri:Area/PubMed/Curation">002298</idno><idno type="wicri:Area/PubMed/Checkpoint">002013</idno><idno type="wicri:Area/Ncbi/Merge">004299</idno><idno type="wicri:Area/Ncbi/Curation">004299</idno><idno type="wicri:Area/Ncbi/Checkpoint">004299</idno><idno type="wicri:doubleKey">0161-813X:1988:Prince M:neuropsychological:effects:of</idno><idno type="wicri:Area/Main/Merge">00A407</idno><idno type="wicri:Area/Main/Curation">009948</idno><idno type="wicri:Area/Main/Exploration">009948</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuropsychological effects of irradiation and chemotherapy treatments upon children with acute lymphoblastic leukemia: a case study of monozygotic twins.</title><author><name sortKey="Prince, M T" sort="Prince, M T" uniqKey="Prince M" first="M T" last="Prince">M T Prince</name><affiliation><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72205.</nlm:affiliation><wicri:noCountry code="subField">Little Rock 72205</wicri:noCountry></affiliation></author><author><name sortKey="Souheaver, G T" sort="Souheaver, G T" uniqKey="Souheaver G" first="G T" last="Souheaver">G T Souheaver</name></author><author><name sortKey="Berry, D H" sort="Berry, D H" uniqKey="Berry D" first="D H" last="Berry">D H Berry</name></author></analytic><series><title level="j">Neurotoxicology</title><idno type="ISSN">0161-813X</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Cognition (drug effects)</term><term>Cognition (radiation effects)</term><term>Combined Modality Therapy</term><term>Diseases in Twins</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Intelligence Tests</term><term>Methotrexate (adverse effects)</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (psychology)</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)</term><term>Radiation Injuries (psychology)</term><term>Twins</term><term>Twins, Monozygotic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Methotrexate</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term><term>Radiation Injuries</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Combined Modality Therapy</term><term>Diseases in Twins</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Intelligence Tests</term><term>Twins</term><term>Twins, Monozygotic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Numerous attempts have been made to determine the effects of irradiation and chemotherapy upon cognitive functioning when used for treatment of acute lymphoblastic leukemia (ALL). While many studies have demonstrated a deleterious effect, others have found no significant changes in neuropsychological functioning. The uncertainty regarding the cognitive effects of these treatments is exemplified via a presentation of monozygotic twins who were evaluated via neuropsychological tests. The children received similar induction-consolidation therapy which included intrathecal methotrexate and cranial irradiation. Neuropsychological tests yielded almost identical I.Q. patterns, however, subtle differences were noted between the children when abstract reasoning abilities, achievement tests scores, motor speed, grip strength, performance on complex tasks requiring haptic sensitivity, and fingertip sensitivity were observed. This discussion also summarizes the previous findings related to cognitive function after chemotherapy and radiation therapy and some of the confounding factors which have been noted.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Berry, D H" sort="Berry, D H" uniqKey="Berry D" first="D H" last="Berry">D H Berry</name><name sortKey="Prince, M T" sort="Prince, M T" uniqKey="Prince M" first="M T" last="Prince">M T Prince</name><name sortKey="Souheaver, G T" sort="Souheaver, G T" uniqKey="Souheaver G" first="G T" last="Souheaver">G T Souheaver</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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