Arm movement maps evoked by cortical magnetic stimulation in a robotic environment
Identifieur interne : 004278 ( Main/Exploration ); précédent : 004277; suivant : 004279Arm movement maps evoked by cortical magnetic stimulation in a robotic environment
Auteurs : Lauren M. Jones-Lush [États-Unis] ; Timothy N. Judkins [États-Unis] ; George F. Wittenberg [États-Unis]Source :
- Neuroscience [ 0306-4522 ] ; 2009.
Abstract
Many neurological diseases result in a severe inability to reach for which there is no proven therapy. Promising new interventions to address reaching rehabilitation using robotic training devices are currently under investigation in clinical trials but the neural mechanisms that underlie these interventions are not understood. Transcranial magnetic stimulation (TMS) may be used to probe such mechanisms quickly and non-invasively, by mapping muscle and movement representations in the primary motor cortex (M1). Here we investigate movement maps in healthy young subjects at rest using TMS in the robotic environment, with the goal of determining the range of TMS accessible movements, as a starting point for the study of cortical plasticity in combination with robotic therapy. We systematically stimulated the left motor cortex of 14 normal volunteers while the right hand and forearm rested in the cradle of a two degree-of-freedom planar rehabilitation robot (IMT). Maps were created by applying 10 stimuli at each of 9 locations (3 × 3 cm grid) centered on the M1 movement hotspot for each subject, defined as the stimulation location that elicited robot cradle movements of the greatest distance. TMS-evoked movement kinematics were measured by the robotic encoders and ranged in magnitude from 0–3 cm. Movement maps varied by subject and by location within a subject. However, movements were very consistent within a single stimulation location for a given subject. Movement vectors remained relatively constant (limited to <90 degree section of the planar field) within some subjects across the entire map, while others covered a wider range of directions. This may be due to individual differences in cortical physiology or anatomy, resulting in a practical limit to the areas that are TMS-accessible. This study provides a baseline inventory of possible TMS-evoked arm movements in the robotic reaching trainer, and thus may provide a real-time, non-invasive platform for neurophysiology based evaluation and therapy in motor rehabilitation settings.
Url:
DOI: 10.1016/j.neuroscience.2009.10.065
PubMed: 19895875
PubMed Central: 2818445
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000F73
- to stream Pmc, to step Curation: 000F73
- to stream Pmc, to step Checkpoint: 002203
- to stream Ncbi, to step Merge: 001322
- to stream Ncbi, to step Curation: 001322
- to stream Ncbi, to step Checkpoint: 001322
- to stream Main, to step Merge: 004359
- to stream Main, to step Curation: 004278
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Arm movement maps evoked by cortical magnetic stimulation in a robotic environment</title>
<author><name sortKey="Jones Lush, Lauren M" sort="Jones Lush, Lauren M" uniqKey="Jones Lush L" first="Lauren M." last="Jones-Lush">Lauren M. Jones-Lush</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Judkins, Timothy N" sort="Judkins, Timothy N" uniqKey="Judkins T" first="Timothy N." last="Judkins">Timothy N. Judkins</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wittenberg, George F" sort="Wittenberg, George F" uniqKey="Wittenberg G" first="George F." last="Wittenberg">George F. Wittenberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurology, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4"> Geriatric Research, Education, and Clinical Center, VA Maryland Health Care System, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Geriatric Research, Education, and Clinical Center, VA Maryland Health Care System, Baltimore</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19895875</idno>
<idno type="pmc">2818445</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818445</idno>
<idno type="RBID">PMC:2818445</idno>
<idno type="doi">10.1016/j.neuroscience.2009.10.065</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000F73</idno>
<idno type="wicri:Area/Pmc/Curation">000F73</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002203</idno>
<idno type="wicri:Area/Ncbi/Merge">001322</idno>
<idno type="wicri:Area/Ncbi/Curation">001322</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001322</idno>
<idno type="wicri:doubleKey">0306-4522:2009:Jones Lush L:arm:movement:maps</idno>
<idno type="wicri:Area/Main/Merge">004359</idno>
<idno type="wicri:Area/Main/Curation">004278</idno>
<idno type="wicri:Area/Main/Exploration">004278</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Arm movement maps evoked by cortical magnetic stimulation in a robotic environment</title>
<author><name sortKey="Jones Lush, Lauren M" sort="Jones Lush, Lauren M" uniqKey="Jones Lush L" first="Lauren M." last="Jones-Lush">Lauren M. Jones-Lush</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Judkins, Timothy N" sort="Judkins, Timothy N" uniqKey="Judkins T" first="Timothy N." last="Judkins">Timothy N. Judkins</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wittenberg, George F" sort="Wittenberg, George F" uniqKey="Wittenberg G" first="George F." last="Wittenberg">George F. Wittenberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurology, University of Maryland School of Medicine, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of Maryland School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4"> Geriatric Research, Education, and Clinical Center, VA Maryland Health Care System, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Geriatric Research, Education, and Clinical Center, VA Maryland Health Care System, Baltimore</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
<idno type="eISSN">1873-7544</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Many neurological diseases result in a severe inability to reach for which there is no proven therapy. Promising new interventions to address reaching rehabilitation using robotic training devices are currently under investigation in clinical trials but the neural mechanisms that underlie these interventions are not understood. Transcranial magnetic stimulation (TMS) may be used to probe such mechanisms quickly and non-invasively, by mapping muscle and movement representations in the primary motor cortex (M1). Here we investigate movement maps in healthy young subjects at rest using TMS in the robotic environment, with the goal of determining the range of TMS accessible movements, as a starting point for the study of cortical plasticity in combination with robotic therapy. We systematically stimulated the left motor cortex of 14 normal volunteers while the right hand and forearm rested in the cradle of a two degree-of-freedom planar rehabilitation robot (IMT). Maps were created by applying 10 stimuli at each of 9 locations (3 × 3 cm grid) centered on the M1 movement hotspot for each subject, defined as the stimulation location that elicited robot cradle movements of the greatest distance. TMS-evoked movement kinematics were measured by the robotic encoders and ranged in magnitude from 0–3 cm. Movement maps varied by subject and by location within a subject. However, movements were very consistent within a single stimulation location for a given subject. Movement vectors remained relatively constant (limited to <90 degree section of the planar field) within some subjects across the entire map, while others covered a wider range of directions. This may be due to individual differences in cortical physiology or anatomy, resulting in a practical limit to the areas that are TMS-accessible. This study provides a baseline inventory of possible TMS-evoked arm movements in the robotic reaching trainer, and thus may provide a real-time, non-invasive platform for neurophysiology based evaluation and therapy in motor rehabilitation settings.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Jones Lush, Lauren M" sort="Jones Lush, Lauren M" uniqKey="Jones Lush L" first="Lauren M." last="Jones-Lush">Lauren M. Jones-Lush</name>
</region>
<name sortKey="Jones Lush, Lauren M" sort="Jones Lush, Lauren M" uniqKey="Jones Lush L" first="Lauren M." last="Jones-Lush">Lauren M. Jones-Lush</name>
<name sortKey="Judkins, Timothy N" sort="Judkins, Timothy N" uniqKey="Judkins T" first="Timothy N." last="Judkins">Timothy N. Judkins</name>
<name sortKey="Wittenberg, George F" sort="Wittenberg, George F" uniqKey="Wittenberg G" first="George F." last="Wittenberg">George F. Wittenberg</name>
<name sortKey="Wittenberg, George F" sort="Wittenberg, George F" uniqKey="Wittenberg G" first="George F." last="Wittenberg">George F. Wittenberg</name>
<name sortKey="Wittenberg, George F" sort="Wittenberg, George F" uniqKey="Wittenberg G" first="George F." last="Wittenberg">George F. Wittenberg</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004278 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004278 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2818445 |texte= Arm movement maps evoked by cortical magnetic stimulation in a robotic environment }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19895875" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |