Mechanics, malignancy, and metastasis: The force journey of a tumor cell
Identifieur interne : 004154 ( Main/Exploration ); précédent : 004153; suivant : 004155Mechanics, malignancy, and metastasis: The force journey of a tumor cell
Auteurs : Sanjay Kumar ; Valerie M. WeaverSource :
- Cancer metastasis reviews [ 0167-7659 ] ; 2009.
Abstract
A cell undergoes many genetic and epigenetic changes as it transitions to malignancy. Malignant transformation is also accompanied by a progressive loss of tissue homeostasis and perturbations in tissue architecture that ultimately culminates in tumor cell invasion into the parenchyma and metastasis to distant organ sites. Increasingly, cancer biologists have begun to recognize that a critical component of this transformation journey involves marked alterations in the
Url:
DOI: 10.1007/s10555-008-9173-4
PubMed: 19153673
PubMed Central: 2658728
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">A cell undergoes many genetic and epigenetic changes as it transitions to malignancy. Malignant transformation is also accompanied by a progressive loss of tissue homeostasis and perturbations in tissue architecture that ultimately culminates in tumor cell invasion into the parenchyma and metastasis to distant organ sites. Increasingly, cancer biologists have begun to recognize that a critical component of this transformation journey involves marked alterations in the <italic>mechanical</italic>
phenotype of the cell and its surrounding microenvironment. These mechanical differences include modifications in cell and tissue structure, adaptive force-induced changes in the environment, altered processing of micromechanical cues encoded in the extracellular matrix (ECM), and cell-directed remodeling of the extracellular stroma. Here, we review critical steps in this “force journey,” including mechanical contributions to tissue dysplasia, invasion of the ECM, and metastasis. We discuss the biophysical basis of this force journey and present recent advances in the measurement of cellular mechanical properties <italic>in vitro</italic>
and <italic>in vivo</italic>
. We end by describing examples of molecular mechanisms through which tumor cells sense, process and respond to mechanical forces in their environment. While our understanding of the mechanical components of tumor growth, survival and motility remains in its infancy, considerable work has already yielded valuable insight into the molecular basis of force-dependent tumor pathophysiology, which offers new directions in cancer chemotherapeutics.</p>
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<name sortKey="Weaver, Valerie M" sort="Weaver, Valerie M" uniqKey="Weaver V" first="Valerie M." last="Weaver">Valerie M. Weaver</name>
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