Effects of Type 2 Diabetes and Insulin on Whole-Body, Splanchnic, and Leg Protein Metabolism
Identifieur interne : 002441 ( Main/Curation ); précédent : 002440; suivant : 002442Effects of Type 2 Diabetes and Insulin on Whole-Body, Splanchnic, and Leg Protein Metabolism
Auteurs : Kevin R. Short ; Brian A. Irving ; Ananda Basu ; C. Michael Johnson ; K. Sreekumaran Nair ; Rita BasuSource :
- The Journal of Clinical Endocrinology and Metabolism [ 0021-972X ] ; 2012.
Abstract
Type 2 diabetes (T2D) is characterized by insulin resistance to glucose metabolism. Most studies suggest that protein metabolism is unaffected by T2D, but regional protein metabolism and response to multiple doses of insulin have not been examined.
Our objective was to determine whether insulin regulation of splanchnic and leg protein metabolism are affected by T2D during hyperglycemia and graded insulin levels.
We conducted a cross-sectional study at an academic medical center.
T2D and non-T2D adults were matched for age (62 yr) and body mass index (30 kg/m2).
Glucose was maintained at approximately 9 mmol/liter while insulin was infused at three progressively higher rates, achieving circulating concentrations of approximately 150, 350, and 700 pmol/liter, respectively.
Protein kinetics were measured using labeled phenylalanine (Phe) and tyrosine (Tyr).
Whole-body protein breakdown and synthesis rates were higher in T2D but declined with increasing insulin in both groups. Leg Phe and Tyr appearance and disappearance and estimates of protein breakdown and synthesis, respectively, were higher in T2D but did not decline significantly with insulin, resulting in similar net balance between groups. Splanchnic response to insulin was blunted in T2D, shown by a smaller reduction in rates of disappearance and net balance of Phe and Tyr as insulin increased. Splanchnic conversion of Phe to Tyr was lower in T2D and less sensitive to insulin, whereas nonsplanchnic Phe to Tyr tended to be higher in T2D.
T2D results in higher whole-body, splanchnic, and leg protein turnover and blunts the insulin-mediated suppression of splanchnic protein anabolism under hyperglycemic, hyperinsulinemic conditions.
Url:
DOI: 10.1210/jc.2012-2533
PubMed: 23032060
PubMed Central: 3591680
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001375
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001375
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001759
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002267
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002267
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002267
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002467
Links to Exploration step
PMC:3591680Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Type 2 Diabetes and Insulin on Whole-Body, Splanchnic, and Leg Protein Metabolism</title>
<author><name sortKey="Short, Kevin R" sort="Short, Kevin R" uniqKey="Short K" first="Kevin R." last="Short">Kevin R. Short</name>
</author>
<author><name sortKey="Irving, Brian A" sort="Irving, Brian A" uniqKey="Irving B" first="Brian A." last="Irving">Brian A. Irving</name>
</author>
<author><name sortKey="Basu, Ananda" sort="Basu, Ananda" uniqKey="Basu A" first="Ananda" last="Basu">Ananda Basu</name>
</author>
<author><name sortKey="Johnson, C Michael" sort="Johnson, C Michael" uniqKey="Johnson C" first="C. Michael" last="Johnson">C. Michael Johnson</name>
</author>
<author><name sortKey="Nair, K Sreekumaran" sort="Nair, K Sreekumaran" uniqKey="Nair K" first="K. Sreekumaran" last="Nair">K. Sreekumaran Nair</name>
</author>
<author><name sortKey="Basu, Rita" sort="Basu, Rita" uniqKey="Basu R" first="Rita" last="Basu">Rita Basu</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23032060</idno>
<idno type="pmc">3591680</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591680</idno>
<idno type="RBID">PMC:3591680</idno>
<idno type="doi">10.1210/jc.2012-2533</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001375</idno>
<idno type="wicri:Area/Pmc/Curation">001375</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001759</idno>
<idno type="wicri:Area/Ncbi/Merge">002267</idno>
<idno type="wicri:Area/Ncbi/Curation">002267</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002267</idno>
<idno type="wicri:doubleKey">0021-972X:2012:Short K:effects:of:type</idno>
<idno type="wicri:Area/Main/Merge">002467</idno>
<idno type="wicri:Area/Main/Curation">002441</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of Type 2 Diabetes and Insulin on Whole-Body, Splanchnic, and Leg Protein Metabolism</title>
<author><name sortKey="Short, Kevin R" sort="Short, Kevin R" uniqKey="Short K" first="Kevin R." last="Short">Kevin R. Short</name>
</author>
<author><name sortKey="Irving, Brian A" sort="Irving, Brian A" uniqKey="Irving B" first="Brian A." last="Irving">Brian A. Irving</name>
</author>
<author><name sortKey="Basu, Ananda" sort="Basu, Ananda" uniqKey="Basu A" first="Ananda" last="Basu">Ananda Basu</name>
</author>
<author><name sortKey="Johnson, C Michael" sort="Johnson, C Michael" uniqKey="Johnson C" first="C. Michael" last="Johnson">C. Michael Johnson</name>
</author>
<author><name sortKey="Nair, K Sreekumaran" sort="Nair, K Sreekumaran" uniqKey="Nair K" first="K. Sreekumaran" last="Nair">K. Sreekumaran Nair</name>
</author>
<author><name sortKey="Basu, Rita" sort="Basu, Rita" uniqKey="Basu R" first="Rita" last="Basu">Rita Basu</name>
</author>
</analytic>
<series><title level="j">The Journal of Clinical Endocrinology and Metabolism</title>
<idno type="ISSN">0021-972X</idno>
<idno type="eISSN">1945-7197</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Context:</title>
<p>Type 2 diabetes (T2D) is characterized by insulin resistance to glucose metabolism. Most studies suggest that protein metabolism is unaffected by T2D, but regional protein metabolism and response to multiple doses of insulin have not been examined.</p>
</sec>
<sec><title>Objective:</title>
<p>Our objective was to determine whether insulin regulation of splanchnic and leg protein metabolism are affected by T2D during hyperglycemia and graded insulin levels.</p>
</sec>
<sec><title>Design and Setting:</title>
<p>We conducted a cross-sectional study at an academic medical center.</p>
</sec>
<sec><title>Participants:</title>
<p>T2D and non-T2D adults were matched for age (62 yr) and body mass index (30 kg/m<sup>2</sup>
).</p>
</sec>
<sec><title>Interventions:</title>
<p>Glucose was maintained at approximately 9 mmol/liter while insulin was infused at three progressively higher rates, achieving circulating concentrations of approximately 150, 350, and 700 pmol/liter, respectively.</p>
</sec>
<sec><title>Main Outcome Measures:</title>
<p>Protein kinetics were measured using labeled phenylalanine (Phe) and tyrosine (Tyr).</p>
</sec>
<sec><title>Results:</title>
<p>Whole-body protein breakdown and synthesis rates were higher in T2D but declined with increasing insulin in both groups. Leg Phe and Tyr appearance and disappearance and estimates of protein breakdown and synthesis, respectively, were higher in T2D but did not decline significantly with insulin, resulting in similar net balance between groups. Splanchnic response to insulin was blunted in T2D, shown by a smaller reduction in rates of disappearance and net balance of Phe and Tyr as insulin increased. Splanchnic conversion of Phe to Tyr was lower in T2D and less sensitive to insulin, whereas nonsplanchnic Phe to Tyr tended to be higher in T2D.</p>
</sec>
<sec><title>Conclusions:</title>
<p>T2D results in higher whole-body, splanchnic, and leg protein turnover and blunts the insulin-mediated suppression of splanchnic protein anabolism under hyperglycemic, hyperinsulinemic conditions.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002441 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002441 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:3591680 |texte= Effects of Type 2 Diabetes and Insulin on Whole-Body, Splanchnic, and Leg Protein Metabolism }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:23032060" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |