Distinct Fine-Scale fMRI Activation Patterns of Contra- and Ipsilateral Somatosensory Areas 3b and 1 in Humans
Identifieur interne : 001288 ( Main/Curation ); précédent : 001287; suivant : 001289Distinct Fine-Scale fMRI Activation Patterns of Contra- and Ipsilateral Somatosensory Areas 3b and 1 in Humans
Auteurs : Elizabeth Ann Stringer [États-Unis] ; Peng-Gang Qiao [République populaire de Chine] ; Robert M. Friedman [États-Unis] ; Lauren Holroyd [États-Unis] ; Allen T. Newton [États-Unis] ; John C. Gore [États-Unis] ; Li Min Chen [États-Unis]Source :
- Human brain mapping [ 1065-9471 ] ; 2014.
Abstract
Inter-areal and ipsilateral cortical responses to tactile stimulation have not been well described in humans S1 cortex. By taking advantage of high signal-to-noise ratio at 7 T, we quantified blood oxygenation level dependent (BOLD) response patterns and time courses to tactile stimuli on individual distal finger pads at a fine spatial scale, and examined whether there are inter-areal (area 3b versus area 1) and inter-hemispheric response differences to unilateral tactile stimulation in healthy human subjects. We found that 2-Hz tactile stimulation of individual fingertips evoked detectable BOLD signal changes in both contralateral and ipsilateral area 3b and area 1. Contralateral digit activations were organized in an orderly somatotopic manner, and BOLD responses in area 3b were more digit selective than those in area 1. However, the area of cortex that was responsive to stimulation of a single digit (stimulus-response field) was similar across areas. In the ipsilateral hemisphere, response magnitudes in both area 3b and area 1 were significantly weaker than those of the contralateral hemisphere. Digit activations exhibited no clear somatotopic organizational pattern in either area 3b or area 1, yet digit-selectivity was retained in area 1 but not in area 3b. The observation of distinct digit-selective responses of contralateral area 3b versus area 1 supports a higher order function of contralateral area 1 in spatial integration. In contrast, ipsilateral cortices may play a less discriminative role in the perception of unilateral tactile sensation in humans.
Url:
DOI: 10.1002/hbm.22517
PubMed: 24692215
PubMed Central: 4107165
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Gore</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Li Min" sort="Chen, Li Min" uniqKey="Chen L" first="Li Min" last="Chen">Li Min Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232</wicri:regionArea><wicri:noRegion>Tennessee 37232</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human brain mapping</title><idno type="ISSN">1065-9471</idno><idno type="eISSN">1097-0193</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Inter-areal and ipsilateral cortical responses to tactile stimulation have not been well described in humans S1 cortex. By taking advantage of high signal-to-noise ratio at 7 T, we quantified blood oxygenation level dependent (BOLD) response patterns and time courses to tactile stimuli on individual distal finger pads at a fine spatial scale, and examined whether there are inter-areal (area 3b versus area 1) and inter-hemispheric response differences to unilateral tactile stimulation in healthy human subjects. We found that 2-Hz tactile stimulation of individual fingertips evoked detectable BOLD signal changes in both contralateral and ipsilateral area 3b and area 1. Contralateral digit activations were organized in an orderly somatotopic manner, and BOLD responses in area 3b were more digit selective than those in area 1. However, the area of cortex that was responsive to stimulation of a single digit (stimulus-response field) was similar across areas. In the ipsilateral hemisphere, response magnitudes in both area 3b and area 1 were significantly weaker than those of the contralateral hemisphere. Digit activations exhibited no clear somatotopic organizational pattern in either area 3b or area 1, yet digit-selectivity was retained in area 1 but not in area 3b. The observation of distinct digit-selective responses of contralateral area 3b versus area 1 supports a higher order function of contralateral area 1 in spatial integration. In contrast, ipsilateral cortices may play a less discriminative role in the perception of unilateral tactile sensation in humans.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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