A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case
Identifieur interne : 000B53 ( Main/Curation ); précédent : 000B52; suivant : 000B54A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case
Auteurs : Alessio Meoli [Italie] ; Elena Cutrì [Italie] ; Adarsh Krishnamurthy [États-Unis] ; Gabriele Dubini [Italie] ; Francesco Migliavacca [Italie] ; Tain-Yen Hsia [Royaume-Uni] ; Giancarlo Pennati [Italie]Source :
- Interface Focus [ 2042-8898 ] ; 2015.
Abstract
Complex congenital heart disease characterized by the underdevelopment of one ventricular chamber (single ventricle (SV) circulation) is normally treated with a three-stage surgical repair. This study aims at developing a multiscale computational framework able to couple a patient-specific three-dimensional finite-element model of the SV to a patient-specific lumped parameter (LP) model of the whole circulation, in a closed-loop fashion. A sequential approach was carried out: (i) cardiocirculatory parameters were estimated by using a fully LP model; (ii) ventricular material parameters and unloaded geometry were identified by means of the stand-alone, three-dimensional model of the SV; and (iii) the three-dimensional model of SV was coupled to the LP model of the circulation, thus closing the loop and creating a multiscale model. Once the patient-specific multiscale model was set using pre-operative clinical data, the virtual surgery was performed, and the post-operative conditions were simulated. This approach allows the analysis of local information on ventricular function as well as global parameters of the cardiovascular system. This methodology is generally applicable to patients suffering from SV disease for surgical planning at different stages of treatment. As an example, a clinical case from stage 1 to stage 2 is considered here.
Url:
DOI: 10.1098/rsfs.2014.0079
PubMed: 25844151
PubMed Central: 4342947
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001361
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001361
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000773
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003814
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003814
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003814
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000B53
Links to Exploration step
PMC:4342947Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case</title>
<author><name sortKey="Meoli, Alessio" sort="Meoli, Alessio" uniqKey="Meoli A" first="Alessio" last="Meoli">Alessio Meoli</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cutri, Elena" sort="Cutri, Elena" uniqKey="Cutri E" first="Elena" last="Cutrì">Elena Cutrì</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krishnamurthy, Adarsh" sort="Krishnamurthy, Adarsh" uniqKey="Krishnamurthy A" first="Adarsh" last="Krishnamurthy">Adarsh Krishnamurthy</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Laboratory of Mechanics Iowa State University</institution>
,<addr-line>Ames, IA 50011</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Cardiothoracic Surgery</addr-line>
,<institution>Great Ormond Street Hospital for Children, NHS Foundation Trust</institution>
,<addr-line>London WC1N 3JH</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25844151</idno>
<idno type="pmc">4342947</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342947</idno>
<idno type="RBID">PMC:4342947</idno>
<idno type="doi">10.1098/rsfs.2014.0079</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001361</idno>
<idno type="wicri:Area/Pmc/Curation">001361</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000773</idno>
<idno type="wicri:Area/Ncbi/Merge">003814</idno>
<idno type="wicri:Area/Ncbi/Curation">003814</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003814</idno>
<idno type="wicri:doubleKey">2042-8898:2015:Meoli A:a:multiscale:model</idno>
<idno type="wicri:Area/Main/Merge">000B53</idno>
<idno type="wicri:Area/Main/Curation">000B53</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case</title>
<author><name sortKey="Meoli, Alessio" sort="Meoli, Alessio" uniqKey="Meoli A" first="Alessio" last="Meoli">Alessio Meoli</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cutri, Elena" sort="Cutri, Elena" uniqKey="Cutri E" first="Elena" last="Cutrì">Elena Cutrì</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krishnamurthy, Adarsh" sort="Krishnamurthy, Adarsh" uniqKey="Krishnamurthy A" first="Adarsh" last="Krishnamurthy">Adarsh Krishnamurthy</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Laboratory of Mechanics Iowa State University</institution>
,<addr-line>Ames, IA 50011</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dubini, Gabriele" sort="Dubini, Gabriele" uniqKey="Dubini G" first="Gabriele" last="Dubini">Gabriele Dubini</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Migliavacca, Francesco" sort="Migliavacca, Francesco" uniqKey="Migliavacca F" first="Francesco" last="Migliavacca">Francesco Migliavacca</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsia, Tain Yen" sort="Hsia, Tain Yen" uniqKey="Hsia T" first="Tain-Yen" last="Hsia">Tain-Yen Hsia</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Cardiothoracic Surgery</addr-line>
,<institution>Great Ormond Street Hospital for Children, NHS Foundation Trust</institution>
,<addr-line>London WC1N 3JH</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pennati, Giancarlo" sort="Pennati, Giancarlo" uniqKey="Pennati G" first="Giancarlo" last="Pennati">Giancarlo Pennati</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Interface Focus</title>
<idno type="ISSN">2042-8898</idno>
<idno type="eISSN">2042-8901</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Complex congenital heart disease characterized by the underdevelopment of one ventricular chamber (single ventricle (SV) circulation) is normally treated with a three-stage surgical repair. This study aims at developing a multiscale computational framework able to couple a patient-specific three-dimensional finite-element model of the SV to a patient-specific lumped parameter (LP) model of the whole circulation, in a closed-loop fashion. A sequential approach was carried out: (i) cardiocirculatory parameters were estimated by using a fully LP model; (ii) ventricular material parameters and unloaded geometry were identified by means of the stand-alone, three-dimensional model of the SV; and (iii) the three-dimensional model of SV was coupled to the LP model of the circulation, thus closing the loop and creating a multiscale model. Once the patient-specific multiscale model was set using pre-operative clinical data, the virtual surgery was performed, and the post-operative conditions were simulated. This approach allows the analysis of local information on ventricular function as well as global parameters of the cardiovascular system. This methodology is generally applicable to patients suffering from SV disease for surgical planning at different stages of treatment. As an example, a clinical case from stage 1 to stage 2 is considered here.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B53 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000B53 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:4342947 |texte= A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:25844151" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
This area was generated with Dilib version V0.6.23. |