Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens
Identifieur interne : 003511 ( Istex/Corpus ); précédent : 003510; suivant : 003512Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens
Auteurs : Liliana Werner ; David J. Apple ; Marcela Escobar-Gomez ; Arne Öhrström ; Basil B. Crayford ; Roberto Bianchi ; Suresh K. PandeySource :
- Ophthalmology [ 0161-6420 ] ; 2000.
Abstract
Objective To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces.Design Noncomparative small case series with clinicopathologic and histochemical correlations.Participants Five hydrophilic IOLs explanted from five different patients. All patients presented with decreased visual acuity and glare circa 12 months after uneventful phacoemulsification and IOL implantation, associated with a red-brown granularity on the optical surfaces of the IOLs.Methods The lenses were explanted, fixed in buffered formaldehyde and examined by gross and light microscopy.Main outcome measures Staining of the IOLs with 1% alizarin red and with the von Kossa method (both stains for calcium). Two additional IOLs were also stained and included as controls.Results The optical surfaces of all five IOLs were covered by a layer of irregular granular deposits, composed of multiple fine, translucent spherical-ovoid granules. The deposits stained positive for calcium in all cases. No deposit or positive staining was observed on the IOLs haptics. Staining of the control IOLs was also negative.Conclusion This is the first histopathological report of calcified deposits on the surfaces of this hydrogel IOL model. Further studies on other similar cases with this lens should be done to determine the incidence and possible mechanisms of this phenomenon.
Url:
DOI: 10.1016/S0161-6420(00)00416-4
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name><affiliation><mods:affiliation>E-mail: appledj@musc.edu</mods:affiliation></affiliation><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Escobar Gomez, Marcela" sort="Escobar Gomez, Marcela" uniqKey="Escobar Gomez M" first="Marcela" last="Escobar-Gomez">Marcela Escobar-Gomez</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Ohrstrom, Arne" sort="Ohrstrom, Arne" uniqKey="Ohrstrom A" first="Arne" last="Öhrström">Arne Öhrström</name><affiliation><mods:affiliation>Department of Ophthalmology, Central Hospital of Vasteras, Vasteras, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Crayford, Basil B" sort="Crayford, Basil B" uniqKey="Crayford B" first="Basil B" last="Crayford">Basil B. Crayford</name><affiliation><mods:affiliation>Dudley Specialist Medical Centre, Orange, Australia</mods:affiliation></affiliation></author><author><name sortKey="Bianchi, Roberto" sort="Bianchi, Roberto" uniqKey="Bianchi R" first="Roberto" last="Bianchi">Roberto Bianchi</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4AB8063E0CAB6197222FD937C687A3E72C3B621B</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0161-6420(00)00416-4</idno><idno type="url">https://api.istex.fr/document/4AB8063E0CAB6197222FD937C687A3E72C3B621B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003511</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name><affiliation><mods:affiliation>E-mail: appledj@musc.edu</mods:affiliation></affiliation><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Escobar Gomez, Marcela" sort="Escobar Gomez, Marcela" uniqKey="Escobar Gomez M" first="Marcela" last="Escobar-Gomez">Marcela Escobar-Gomez</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Ohrstrom, Arne" sort="Ohrstrom, Arne" uniqKey="Ohrstrom A" first="Arne" last="Öhrström">Arne Öhrström</name><affiliation><mods:affiliation>Department of Ophthalmology, Central Hospital of Vasteras, Vasteras, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Crayford, Basil B" sort="Crayford, Basil B" uniqKey="Crayford B" first="Basil B" last="Crayford">Basil B. Crayford</name><affiliation><mods:affiliation>Dudley Specialist Medical Centre, Orange, Australia</mods:affiliation></affiliation></author><author><name sortKey="Bianchi, Roberto" sort="Bianchi, Roberto" uniqKey="Bianchi R" first="Roberto" last="Bianchi">Roberto Bianchi</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Ophthalmology</title><title level="j" type="abbrev">OPHTHA</title><idno type="ISSN">0161-6420</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">107</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2179">2179</biblScope><biblScope unit="page" to="2185">2185</biblScope></imprint><idno type="ISSN">0161-6420</idno></series><idno type="istex">4AB8063E0CAB6197222FD937C687A3E72C3B621B</idno><idno type="DOI">10.1016/S0161-6420(00)00416-4</idno><idno type="PII">S0161-6420(00)00416-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0161-6420</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces.Design Noncomparative small case series with clinicopathologic and histochemical correlations.Participants Five hydrophilic IOLs explanted from five different patients. All patients presented with decreased visual acuity and glare circa 12 months after uneventful phacoemulsification and IOL implantation, associated with a red-brown granularity on the optical surfaces of the IOLs.Methods The lenses were explanted, fixed in buffered formaldehyde and examined by gross and light microscopy.Main outcome measures Staining of the IOLs with 1% alizarin red and with the von Kossa method (both stains for calcium). Two additional IOLs were also stained and included as controls.Results The optical surfaces of all five IOLs were covered by a layer of irregular granular deposits, composed of multiple fine, translucent spherical-ovoid granules. The deposits stained positive for calcium in all cases. No deposit or positive staining was observed on the IOLs haptics. Staining of the control IOLs was also negative.Conclusion This is the first histopathological report of calcified deposits on the surfaces of this hydrogel IOL model. Further studies on other similar cases with this lens should be done to determine the incidence and possible mechanisms of this phenomenon.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Liliana Werner MD, PhD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>David J Apple MD</name><affiliations><json:string>E-mail: appledj@musc.edu</json:string><json:string>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Marcela Escobar-Gomez MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Arne Öhrström MD</name><affiliations><json:string>Department of Ophthalmology, Central Hospital of Vasteras, Vasteras, Sweden</json:string></affiliations></json:item><json:item><name>Basil B Crayford</name><affiliations><json:string>Dudley Specialist Medical Centre, Orange, Australia</json:string></affiliations></json:item><json:item><name>Roberto Bianchi MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Suresh K Pandey MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><abstract>Objective To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces.Design Noncomparative small case series with clinicopathologic and histochemical correlations.Participants Five hydrophilic IOLs explanted from five different patients. All patients presented with decreased visual acuity and glare circa 12 months after uneventful phacoemulsification and IOL implantation, associated with a red-brown granularity on the optical surfaces of the IOLs.Methods The lenses were explanted, fixed in buffered formaldehyde and examined by gross and light microscopy.Main outcome measures Staining of the IOLs with 1% alizarin red and with the von Kossa method (both stains for calcium). Two additional IOLs were also stained and included as controls.Results The optical surfaces of all five IOLs were covered by a layer of irregular granular deposits, composed of multiple fine, translucent spherical-ovoid granules. The deposits stained positive for calcium in all cases. No deposit or positive staining was observed on the IOLs haptics. Staining of the control IOLs was also negative.Conclusion This is the first histopathological report of calcified deposits on the surfaces of this hydrogel IOL model. Further studies on other similar cases with this lens should be done to determine the incidence and possible mechanisms of this phenomenon.</abstract><qualityIndicators><score>6.644</score><pdfVersion>1.2</pdfVersion><pdfPageSize>586 x 786 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1492</abstractCharCount><pdfWordCount>4100</pdfWordCount><pdfCharCount>25623</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>212</abstractWordCount></qualityIndicators><title>Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title><pii><json:string>S0161-6420(00)00416-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>107</volume><pii><json:string>S0161-6420(00)X0013-9</json:string></pii><pages><last>2185</last><first>2179</first></pages><issn><json:string>0161-6420</json:string></issn><issue>12</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Ophthalmology</title><publicationDate>2000</publicationDate></host><categories><wos><json:string>OPHTHALMOLOGY</json:string></wos></categories><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1016/S0161-6420(00)00416-4</json:string></doi><id>4AB8063E0CAB6197222FD937C687A3E72C3B621B</id><score>1</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/4AB8063E0CAB6197222FD937C687A3E72C3B621B/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/4AB8063E0CAB6197222FD937C687A3E72C3B621B/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/4AB8063E0CAB6197222FD937C687A3E72C3B621B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4AB8063E0CAB6197222FD937C687A3E72C3B621B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2000</date></publicationStmt><notesStmt><note>Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.</note><note>Manuscript no. 200170.</note><note>The authors have no financial or proprietary interest in any product mentioned in this paper.</note><note type="content">Figure 1: Slit-lamp photograph from the patient in case number 3, showing a dusty haze or granularity present on the anterior surface of the lens.</note><note type="content">Figure 2: Photomicrographs from case number 1. Granular deposits can be observed covering the optical surface of this lens, with an intervening clear area corresponding to marks caused by forceps during the folding process (A and B). The deposits stained positive with alizarin red (C and D). In higher magnification (D), the presence of fewer deposits can be observed in the forceps imprints. A: unstained; original magnification ×40. B: unstained; original magnification ×100. C: alizarin red: original magnification ×20. D: alizarin red; original magnification ×200.</note><note type="content">Figure 3: Photomicrographs from case number 3. Two parallel clear lines demarcate the imprints of folding/holding forceps (A). The optical surface of this lens is almost completely covered by the granular deposits, and some pits related to Nd: YAG laser shots can be observed in B. The deposits stained positive with alizarin red (C and D). A: unstained; original magnification ×20. B: unstained; original magnification ×200. C: alizarin red; original magnification ×20. D: alizarin red; original magnification ×200.</note><note type="content">Figure 4: Photomicrographs from cases number 2 (A) and number 3 (B), showing sagittal sections of the lens optic. The lens material itself was dissolved during the preparation for histological examination, but the lens optic surface is delineated by a continuous layer of dark brown, irregular granules. A: von Kossa’s stain; original magnification ×400. B: von Kossa’s stain; original magnification ×200.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title><author><persName><forename type="first">Liliana</forename><surname>Werner</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">David J</forename><surname>Apple</surname></persName><roleName type="degree">MD</roleName><email>appledj@musc.edu</email><note type="correspondence"><p>Correspondence and reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Avenue, P.O. Box 250676, Charleston, SC, 29425-5536. Phone: (843) 792-2760; fax: (843) 792-7920</p></note><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Marcela</forename><surname>Escobar-Gomez</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Arne</forename><surname>Öhrström</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Ophthalmology, Central Hospital of Vasteras, Vasteras, Sweden</affiliation></author><author><persName><forename type="first">Basil B</forename><surname>Crayford</surname></persName><note type="biography">FRACO</note><affiliation>FRACO</affiliation><affiliation>Dudley Specialist Medical Centre, Orange, Australia</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Bianchi</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Suresh K</forename><surname>Pandey</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author></analytic><monogr><title level="j">Ophthalmology</title><title level="j" type="abbrev">OPHTHA</title><idno type="pISSN">0161-6420</idno><idno type="PII">S0161-6420(00)X0013-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">107</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2179">2179</biblScope><biblScope unit="page" to="2185">2185</biblScope></imprint></monogr><idno type="istex">4AB8063E0CAB6197222FD937C687A3E72C3B621B</idno><idno type="DOI">10.1016/S0161-6420(00)00416-4</idno><idno type="PII">S0161-6420(00)00416-4</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces.Design Noncomparative small case series with clinicopathologic and histochemical correlations.Participants Five hydrophilic IOLs explanted from five different patients. All patients presented with decreased visual acuity and glare circa 12 months after uneventful phacoemulsification and IOL implantation, associated with a red-brown granularity on the optical surfaces of the IOLs.Methods The lenses were explanted, fixed in buffered formaldehyde and examined by gross and light microscopy.Main outcome measures Staining of the IOLs with 1% alizarin red and with the von Kossa method (both stains for calcium). Two additional IOLs were also stained and included as controls.Results The optical surfaces of all five IOLs were covered by a layer of irregular granular deposits, composed of multiple fine, translucent spherical-ovoid granules. The deposits stained positive for calcium in all cases. No deposit or positive staining was observed on the IOLs haptics. Staining of the control IOLs was also negative.Conclusion This is the first histopathological report of calcified deposits on the surfaces of this hydrogel IOL model. Further studies on other similar cases with this lens should be done to determine the incidence and possible mechanisms of this phenomenon.</p></abstract></profileDesc><revisionDesc><change when="2000-07-17">Registration</change><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="GR1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="GR2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="GR3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="GR4"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>OPHTHA</jid><aid>598</aid><ce:pii>S0161-6420(00)00416-4</ce:pii><ce:doi>10.1016/S0161-6420(00)00416-4</ce:doi><ce:copyright type="society" year="2000">American Academy of Ophthalmology, Inc.</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.</ce:note-para></ce:article-footnote><ce:title>Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens<ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>The authors have no financial or proprietary interest in any product mentioned in this paper.</ce:note-para></ce:footnote></ce:title><ce:author-group><ce:author><ce:given-name>Liliana</ce:given-name><ce:surname>Werner</ce:surname><ce:degrees>MD, PhD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David J</ce:given-name><ce:surname>Apple</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>appledj@musc.edu</ce:e-address></ce:author><ce:author><ce:given-name>Marcela</ce:given-name><ce:surname>Escobar-Gomez</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:indexed-name>Ohrstrom</ce:indexed-name><ce:given-name>Arne</ce:given-name><ce:surname>Öhrström</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Basil B</ce:given-name><ce:surname>Crayford</ce:surname><ce:roles>FRACO</ce:roles><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Roberto</ce:given-name><ce:surname>Bianchi</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Suresh K</ce:given-name><ce:surname>Pandey</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Department of Ophthalmology, Central Hospital of Vasteras, Vasteras, Sweden</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>3</ce:label><ce:textfn>Dudley Specialist Medical Centre, Orange, Australia</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Correspondence and reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Avenue, P.O. Box 250676, Charleston, SC, 29425-5536. Phone: (843) 792-2760; fax: (843) 792-7920</ce:text></ce:correspondence></ce:author-group><ce:date-received day="27" month="3" year="2000"></ce:date-received><ce:date-accepted day="17" month="7" year="2000"></ce:date-accepted><ce:miscellaneous>Manuscript no. 200170.</ce:miscellaneous><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:section-title>Objective</ce:section-title><ce:simple-para>To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Design</ce:section-title><ce:simple-para>Noncomparative small case series with clinicopathologic and histochemical correlations.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Participants</ce:section-title><ce:simple-para>Five hydrophilic IOLs explanted from five different patients. All patients presented with decreased visual acuity and glare circa 12 months after uneventful phacoemulsification and IOL implantation, associated with a red-brown granularity on the optical surfaces of the IOLs.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Methods</ce:section-title><ce:simple-para>The lenses were explanted, fixed in buffered formaldehyde and examined by gross and light microscopy.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Main outcome measures</ce:section-title><ce:simple-para>Staining of the IOLs with 1% alizarin red and with the von Kossa method (both stains for calcium). Two additional IOLs were also stained and included as controls.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Results</ce:section-title><ce:simple-para>The optical surfaces of all five IOLs were covered by a layer of irregular granular deposits, composed of multiple fine, translucent spherical-ovoid granules. The deposits stained positive for calcium in all cases. No deposit or positive staining was observed on the IOLs haptics. Staining of the control IOLs was also negative.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Conclusion</ce:section-title><ce:simple-para>This is the first histopathological report of calcified deposits on the surfaces of this hydrogel IOL model. Further studies on other similar cases with this lens should be done to determine the incidence and possible mechanisms of this phenomenon.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens</title></titleInfo><name type="personal"><namePart type="given">Liliana</namePart><namePart type="family">Werner</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David J</namePart><namePart type="family">Apple</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>E-mail: appledj@musc.edu</affiliation><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><description>Correspondence and reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Avenue, P.O. Box 250676, Charleston, SC, 29425-5536. Phone: (843) 792-2760; fax: (843) 792-7920</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marcela</namePart><namePart type="family">Escobar-Gomez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arne</namePart><namePart type="family">Öhrström</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Ophthalmology, Central Hospital of Vasteras, Vasteras, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Basil B</namePart><namePart type="family">Crayford</namePart><description>FRACO</description><affiliation>Dudley Specialist Medical Centre, Orange, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Bianchi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suresh K</namePart><namePart type="family">Pandey</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><dateValid encoding="w3cdtf">2000-07-17</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Objective To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces.Design Noncomparative small case series with clinicopathologic and histochemical correlations.Participants Five hydrophilic IOLs explanted from five different patients. All patients presented with decreased visual acuity and glare circa 12 months after uneventful phacoemulsification and IOL implantation, associated with a red-brown granularity on the optical surfaces of the IOLs.Methods The lenses were explanted, fixed in buffered formaldehyde and examined by gross and light microscopy.Main outcome measures Staining of the IOLs with 1% alizarin red and with the von Kossa method (both stains for calcium). Two additional IOLs were also stained and included as controls.Results The optical surfaces of all five IOLs were covered by a layer of irregular granular deposits, composed of multiple fine, translucent spherical-ovoid granules. The deposits stained positive for calcium in all cases. No deposit or positive staining was observed on the IOLs haptics. Staining of the control IOLs was also negative.Conclusion This is the first histopathological report of calcified deposits on the surfaces of this hydrogel IOL model. Further studies on other similar cases with this lens should be done to determine the incidence and possible mechanisms of this phenomenon.</abstract><note>Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.</note><note>Manuscript no. 200170.</note><note type="footnote">The authors have no financial or proprietary interest in any product mentioned in this paper.</note><note type="content">Figure 1: Slit-lamp photograph from the patient in case number 3, showing a dusty haze or granularity present on the anterior surface of the lens.</note><note type="content">Figure 2: Photomicrographs from case number 1. Granular deposits can be observed covering the optical surface of this lens, with an intervening clear area corresponding to marks caused by forceps during the folding process (A and B). The deposits stained positive with alizarin red (C and D). In higher magnification (D), the presence of fewer deposits can be observed in the forceps imprints. A: unstained; original magnification ×40. B: unstained; original magnification ×100. C: alizarin red: original magnification ×20. D: alizarin red; original magnification ×200.</note><note type="content">Figure 3: Photomicrographs from case number 3. Two parallel clear lines demarcate the imprints of folding/holding forceps (A). The optical surface of this lens is almost completely covered by the granular deposits, and some pits related to Nd: YAG laser shots can be observed in B. The deposits stained positive with alizarin red (C and D). A: unstained; original magnification ×20. B: unstained; original magnification ×200. C: alizarin red; original magnification ×20. D: alizarin red; original magnification ×200.</note><note type="content">Figure 4: Photomicrographs from cases number 2 (A) and number 3 (B), showing sagittal sections of the lens optic. The lens material itself was dissolved during the preparation for histological examination, but the lens optic surface is delineated by a continuous layer of dark brown, irregular granules. A: von Kossa’s stain; original magnification ×400. B: von Kossa’s stain; original magnification ×200.</note><relatedItem type="host"><titleInfo><title>Ophthalmology</title></titleInfo><titleInfo type="abbreviated"><title>OPHTHA</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">200012</dateIssued></originInfo><identifier type="ISSN">0161-6420</identifier><identifier type="PII">S0161-6420(00)X0013-9</identifier><part><date>200012</date><detail type="volume"><number>107</number><caption>vol.</caption></detail><detail type="issue"><number>12</number><caption>no.</caption></detail><extent unit="issue pages"><start>A1</start><end>A34</end></extent><extent unit="issue pages"><start>2115</start><end>2432</end></extent><extent unit="pages"><start>2179</start><end>2185</end></extent></part></relatedItem><identifier type="istex">4AB8063E0CAB6197222FD937C687A3E72C3B621B</identifier><identifier type="DOI">10.1016/S0161-6420(00)00416-4</identifier><identifier type="PII">S0161-6420(00)00416-4</identifier><accessCondition type="use and reproduction" contentType="">© 2000American Academy of Ophthalmology, Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>American Academy of Ophthalmology, Inc., ©2000</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/4AB8063E0CAB6197222FD937C687A3E72C3B621B/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">OPHTHALMOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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