Development and clinical assessment of an artificial cornea
Identifieur interne : 002476 ( Istex/Corpus ); précédent : 002475; suivant : 002477Development and clinical assessment of an artificial cornea
Auteurs : C. Hicks ; G. Crawford ; T. Chirila ; S. Wiffen ; S. Vijayasekaran ; X. Lou ; J. Fitton ; M. Maley ; A. Clayton ; P. Dalton ; S. Platten ; B. Ziegelaar ; Y. Hong ; A. Russo ; I. ConstableSource :
- Progress in Retinal and Eye Research [ 1350-9462 ] ; 2000.
Abstract
Keratoprosthesis research has been a gradual, rather fragmentary process with advances being made by isolated groups of researchers. This has arisen partly because of poor funding in the area; research groups which have achieved commercial support have often had constraints upon the full disclosure of their findings. Despite these difficulties there has been real progress over the last decade by several independent groups. This article concentrates upon our own development of a hydrogel core-and-skirt keratoprosthesis, the Chirila KPro, in order to illustrate the scientific and clinical problems common to keratoprosthesis research. Pilot data from a clinical trial is presented and the priorities for future research are discussed.
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DOI: 10.1016/S1350-9462(99)00013-0
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Crawford</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Chirila, T" sort="Chirila, T" uniqKey="Chirila T" first="T" last="Chirila">T. Chirila</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Wiffen, S" sort="Wiffen, S" uniqKey="Wiffen S" first="S" last="Wiffen">S. 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Lou</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Fitton, J" sort="Fitton, J" uniqKey="Fitton J" first="J" last="Fitton">J. Fitton</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Maley, M" sort="Maley, M" uniqKey="Maley M" first="M" last="Maley">M. Maley</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Clayton, A" sort="Clayton, A" uniqKey="Clayton A" first="A" last="Clayton">A. Clayton</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Dalton, P" sort="Dalton, P" uniqKey="Dalton P" first="P" last="Dalton">P. Dalton</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Platten, S" sort="Platten, S" uniqKey="Platten S" first="S" last="Platten">S. Platten</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Ziegelaar, B" sort="Ziegelaar, B" uniqKey="Ziegelaar B" first="B" last="Ziegelaar">B. Ziegelaar</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Hong, Y" sort="Hong, Y" uniqKey="Hong Y" first="Y" last="Hong">Y. Hong</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Russo, A" sort="Russo, A" uniqKey="Russo A" first="A" last="Russo">A. Russo</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Constable, I" sort="Constable, I" uniqKey="Constable I" first="I" last="Constable">I. Constable</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AADC67DF27B481E3B03C0F04BF88D69A7E511A50</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S1350-9462(99)00013-0</idno><idno type="url">https://api.istex.fr/document/AADC67DF27B481E3B03C0F04BF88D69A7E511A50/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Development and clinical assessment of an artificial cornea</title><author><name sortKey="Hicks, C" sort="Hicks, C" uniqKey="Hicks C" first="C" last="Hicks">C. Hicks</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: +61-8-9381-0877; Fax: +61-8-9382-1171</mods:affiliation></affiliation></author><author><name sortKey="Crawford, G" sort="Crawford, G" uniqKey="Crawford G" first="G" last="Crawford">G. Crawford</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Chirila, T" sort="Chirila, T" uniqKey="Chirila T" first="T" last="Chirila">T. Chirila</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Wiffen, S" sort="Wiffen, S" uniqKey="Wiffen S" first="S" last="Wiffen">S. Wiffen</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Vijayasekaran, S" sort="Vijayasekaran, S" uniqKey="Vijayasekaran S" first="S" last="Vijayasekaran">S. Vijayasekaran</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Lou, X" sort="Lou, X" uniqKey="Lou X" first="X" last="Lou">X. Lou</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Fitton, J" sort="Fitton, J" uniqKey="Fitton J" first="J" last="Fitton">J. Fitton</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Maley, M" sort="Maley, M" uniqKey="Maley M" first="M" last="Maley">M. Maley</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Clayton, A" sort="Clayton, A" uniqKey="Clayton A" first="A" last="Clayton">A. Clayton</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Dalton, P" sort="Dalton, P" uniqKey="Dalton P" first="P" last="Dalton">P. Dalton</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Platten, S" sort="Platten, S" uniqKey="Platten S" first="S" last="Platten">S. Platten</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Ziegelaar, B" sort="Ziegelaar, B" uniqKey="Ziegelaar B" first="B" last="Ziegelaar">B. Ziegelaar</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Hong, Y" sort="Hong, Y" uniqKey="Hong Y" first="Y" last="Hong">Y. Hong</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Russo, A" sort="Russo, A" uniqKey="Russo A" first="A" last="Russo">A. Russo</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author><author><name sortKey="Constable, I" sort="Constable, I" uniqKey="Constable I" first="I" last="Constable">I. Constable</name><affiliation><mods:affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Progress in Retinal and Eye Research</title><title level="j" type="abbrev">JPRR</title><idno type="ISSN">1350-9462</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="170">170</biblScope></imprint><idno type="ISSN">1350-9462</idno></series><idno type="istex">AADC67DF27B481E3B03C0F04BF88D69A7E511A50</idno><idno type="DOI">10.1016/S1350-9462(99)00013-0</idno><idno type="PII">S1350-9462(99)00013-0</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1350-9462</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Keratoprosthesis research has been a gradual, rather fragmentary process with advances being made by isolated groups of researchers. This has arisen partly because of poor funding in the area; research groups which have achieved commercial support have often had constraints upon the full disclosure of their findings. Despite these difficulties there has been real progress over the last decade by several independent groups. This article concentrates upon our own development of a hydrogel core-and-skirt keratoprosthesis, the Chirila KPro, in order to illustrate the scientific and clinical problems common to keratoprosthesis research. Pilot data from a clinical trial is presented and the priorities for future research are discussed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C Hicks</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string><json:string>Corresponding author. Tel.: +61-8-9381-0877; Fax: +61-8-9382-1171</json:string></affiliations></json:item><json:item><name>G Crawford</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>T Chirila</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>S Wiffen</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>S Vijayasekaran</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>X Lou</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>J Fitton</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>M Maley</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>A Clayton</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>P Dalton</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>S Platten</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>B Ziegelaar</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>Y Hong</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>A Russo</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item><json:item><name>I Constable</name><affiliations><json:string>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</json:string><json:string>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><abstract>Keratoprosthesis research has been a gradual, rather fragmentary process with advances being made by isolated groups of researchers. This has arisen partly because of poor funding in the area; research groups which have achieved commercial support have often had constraints upon the full disclosure of their findings. Despite these difficulties there has been real progress over the last decade by several independent groups. This article concentrates upon our own development of a hydrogel core-and-skirt keratoprosthesis, the Chirila KPro, in order to illustrate the scientific and clinical problems common to keratoprosthesis research. Pilot data from a clinical trial is presented and the priorities for future research are discussed.</abstract><qualityIndicators><score>6.284</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>739</abstractCharCount><pdfWordCount>9413</pdfWordCount><pdfCharCount>58082</pdfCharCount><pdfPageCount>22</pdfPageCount><abstractWordCount>107</abstractWordCount></qualityIndicators><title>Development and clinical assessment of an artificial cornea</title><pii><json:string>S1350-9462(99)00013-0</json:string></pii><genre><json:string>review-article</json:string></genre><host><volume>19</volume><pii><json:string>S1350-9462(00)X0019-5</json:string></pii><pages><last>170</last><first>149</first></pages><issn><json:string>1350-9462</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Progress in Retinal and Eye Research</title><publicationDate>2000</publicationDate></host><categories><wos><json:string>OPHTHALMOLOGY</json:string></wos></categories><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1016/S1350-9462(99)00013-0</json:string></doi><id>AADC67DF27B481E3B03C0F04BF88D69A7E511A50</id><score>1</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AADC67DF27B481E3B03C0F04BF88D69A7E511A50/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AADC67DF27B481E3B03C0F04BF88D69A7E511A50/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AADC67DF27B481E3B03C0F04BF88D69A7E511A50/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AADC67DF27B481E3B03C0F04BF88D69A7E511A50/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Development and clinical assessment of an artificial cornea</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2000</date></publicationStmt><notesStmt><note type="content">Fig. 1: Type I Chirila KPro in a rabbit, 2.5 years after implantation.</note><note type="content">Fig. 2: Light micrograph of skirt region of a KPro explanted from a rabbit cornea, demonstrating fibroblastic biocolonisation.</note><note type="content">Fig. 3: Graph showing collagenase production in association with implantation of PHEMA sponges in rabbit corneas treated in vivo with a selection of anticollagenase drugs.</note><note type="content">Fig. 4: Graph showing the percentage of dead cells within PHEMA implants over time.</note><note type="content">Fig. 5: Diagram of Type I Chirila KPro.</note><note type="content">Fig. 6: Diagram showing method of implantation of Type I KPro.</note><note type="content">Fig. 7: Diagram of Type II Chirila KPro.</note><note type="content">Fig. 8: Diagrams of method of implantation of Type II Chirila KPro. (a) Scleral incision, (b) Pocket formation, (c) Trephination of posterior lamellar of cornea. (d) Positioning of KPro and suturing scleral incision.</note><note type="content">Fig. 9: MRI showing Type I KPro after implantation.</note><note type="content">Fig. 10: Patient 1 before KPro surgery.</note><note type="content">Fig. 11: Patient 1 one month after KPro implantation, prior to opening of conjunctival flap.</note><note type="content">Fig. 12: Opening the conjunctival flap in patient 1.</note><note type="content">Fig. 13: Patient 1 one week after flap opening.</note><note type="content">Fig. 14: Patient 1: visual field after flap opening, showing glaucomatous hemifield.</note><note type="content">Fig. 15: Patient 1 showing appearance after KPro-graft exchange.</note><note type="content">Fig. 16: Patient 7 showing (a) initial opening in conjunctival flap over Type II KPro (b) final appearance after secondary enlargement of conjunctival opening.</note><note type="content">Table 1: Summary of first 7 cases in Chirila PHEMA KPro trial</note><note type="content">Table 2: Summary of complications in trial of Chirila PHEMA KPro (Type I and Type II): preliminary data to July 1999</note><note type="content">Table 3: Type I Chirila KPro outcomes</note><note type="content">Table 4: Type II Chirila KPro outcomes: preliminary data to July 1999</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Development and clinical assessment of an artificial cornea</title><author><persName><forename type="first">C</forename><surname>Hicks</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><affiliation>Corresponding author. Tel.: +61-8-9381-0877; Fax: +61-8-9382-1171</affiliation></author><author><persName><forename type="first">G</forename><surname>Crawford</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">T</forename><surname>Chirila</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">S</forename><surname>Wiffen</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">S</forename><surname>Vijayasekaran</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">X</forename><surname>Lou</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">J</forename><surname>Fitton</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">M</forename><surname>Maley</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">A</forename><surname>Clayton</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">P</forename><surname>Dalton</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">S</forename><surname>Platten</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">B</forename><surname>Ziegelaar</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">Y</forename><surname>Hong</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">A</forename><surname>Russo</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author><author><persName><forename type="first">I</forename><surname>Constable</surname></persName><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation></author></analytic><monogr><title level="j">Progress in Retinal and Eye Research</title><title level="j" type="abbrev">JPRR</title><idno type="pISSN">1350-9462</idno><idno type="PII">S1350-9462(00)X0019-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">19</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="170">170</biblScope></imprint></monogr><idno type="istex">AADC67DF27B481E3B03C0F04BF88D69A7E511A50</idno><idno type="DOI">10.1016/S1350-9462(99)00013-0</idno><idno type="PII">S1350-9462(99)00013-0</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Keratoprosthesis research has been a gradual, rather fragmentary process with advances being made by isolated groups of researchers. This has arisen partly because of poor funding in the area; research groups which have achieved commercial support have often had constraints upon the full disclosure of their findings. Despite these difficulties there has been real progress over the last decade by several independent groups. This article concentrates upon our own development of a hydrogel core-and-skirt keratoprosthesis, the Chirila KPro, in order to illustrate the scientific and clinical problems common to keratoprosthesis research. Pilot data from a clinical trial is presented and the priorities for future research are discussed.</p></abstract></profileDesc><revisionDesc><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="gr3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="gr4"></istex:entity><istex:entity SYSTEM="gr5" NDATA="IMAGE" name="gr5"></istex:entity><istex:entity SYSTEM="gr6" NDATA="IMAGE" name="gr6"></istex:entity><istex:entity SYSTEM="gr7" NDATA="IMAGE" 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docsubtype="rev"><item-info><jid>JPRR</jid><aid>146</aid><ce:pii>S1350-9462(99)00013-0</ce:pii><ce:doi>10.1016/S1350-9462(99)00013-0</ce:doi><ce:copyright type="full-transfer" year="2000">Elsevier Science Ltd</ce:copyright></item-info><head><ce:title>Development and clinical assessment of an artificial cornea</ce:title><ce:author-group><ce:author><ce:given-name>C</ce:given-name><ce:surname>Hicks</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>G</ce:given-name><ce:surname>Crawford</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T</ce:given-name><ce:surname>Chirila</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S</ce:given-name><ce:surname>Wiffen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S</ce:given-name><ce:surname>Vijayasekaran</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>X</ce:given-name><ce:surname>Lou</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J</ce:given-name><ce:surname>Fitton</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M</ce:given-name><ce:surname>Maley</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A</ce:given-name><ce:surname>Clayton</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P</ce:given-name><ce:surname>Dalton</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S</ce:given-name><ce:surname>Platten</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>B</ce:given-name><ce:surname>Ziegelaar</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Y</ce:given-name><ce:surname>Hong</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A</ce:given-name><ce:surname>Russo</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>I</ce:given-name><ce:surname>Constable</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +61-8-9381-0877; Fax: +61-8-9382-1171</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Keratoprosthesis research has been a gradual, rather fragmentary process with advances being made by isolated groups of researchers. This has arisen partly because of poor funding in the area; research groups which have achieved commercial support have often had constraints upon the full disclosure of their findings. Despite these difficulties there has been real progress over the last decade by several independent groups. This article concentrates upon our own development of a hydrogel core-and-skirt keratoprosthesis, the Chirila KPro, in order to illustrate the scientific and clinical problems common to keratoprosthesis research. Pilot data from a clinical trial is presented and the priorities for future research are discussed.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Development and clinical assessment of an artificial cornea</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Development and clinical assessment of an artificial cornea</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Hicks</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><affiliation>Corresponding author. Tel.: +61-8-9381-0877; Fax: +61-8-9382-1171</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Crawford</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Chirila</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wiffen</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Vijayasekaran</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Lou</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Fitton</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Maley</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Clayton</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Dalton</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Platten</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Ziegelaar</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Hong</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Russo</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Constable</namePart><affiliation>Lions Eye Institute, 2 Verdun Street, Nedlands, Western Australia 6009, Australia</affiliation><affiliation>Centre for Ophthalmology and Visual Science, University of Western Australia, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Keratoprosthesis research has been a gradual, rather fragmentary process with advances being made by isolated groups of researchers. This has arisen partly because of poor funding in the area; research groups which have achieved commercial support have often had constraints upon the full disclosure of their findings. Despite these difficulties there has been real progress over the last decade by several independent groups. This article concentrates upon our own development of a hydrogel core-and-skirt keratoprosthesis, the Chirila KPro, in order to illustrate the scientific and clinical problems common to keratoprosthesis research. Pilot data from a clinical trial is presented and the priorities for future research are discussed.</abstract><note type="content">Fig. 1: Type I Chirila KPro in a rabbit, 2.5 years after implantation.</note><note type="content">Fig. 2: Light micrograph of skirt region of a KPro explanted from a rabbit cornea, demonstrating fibroblastic biocolonisation.</note><note type="content">Fig. 3: Graph showing collagenase production in association with implantation of PHEMA sponges in rabbit corneas treated in vivo with a selection of anticollagenase drugs.</note><note type="content">Fig. 4: Graph showing the percentage of dead cells within PHEMA implants over time.</note><note type="content">Fig. 5: Diagram of Type I Chirila KPro.</note><note type="content">Fig. 6: Diagram showing method of implantation of Type I KPro.</note><note type="content">Fig. 7: Diagram of Type II Chirila KPro.</note><note type="content">Fig. 8: Diagrams of method of implantation of Type II Chirila KPro. (a) Scleral incision, (b) Pocket formation, (c) Trephination of posterior lamellar of cornea. (d) Positioning of KPro and suturing scleral incision.</note><note type="content">Fig. 9: MRI showing Type I KPro after implantation.</note><note type="content">Fig. 10: Patient 1 before KPro surgery.</note><note type="content">Fig. 11: Patient 1 one month after KPro implantation, prior to opening of conjunctival flap.</note><note type="content">Fig. 12: Opening the conjunctival flap in patient 1.</note><note type="content">Fig. 13: Patient 1 one week after flap opening.</note><note type="content">Fig. 14: Patient 1: visual field after flap opening, showing glaucomatous hemifield.</note><note type="content">Fig. 15: Patient 1 showing appearance after KPro-graft exchange.</note><note type="content">Fig. 16: Patient 7 showing (a) initial opening in conjunctival flap over Type II KPro (b) final appearance after secondary enlargement of conjunctival opening.</note><note type="content">Table 1: Summary of first 7 cases in Chirila PHEMA KPro trial</note><note type="content">Table 2: Summary of complications in trial of Chirila PHEMA KPro (Type I and Type II): preliminary data to July 1999</note><note type="content">Table 3: Type I Chirila KPro outcomes</note><note type="content">Table 4: Type II Chirila KPro outcomes: preliminary data to July 1999</note><relatedItem type="host"><titleInfo><title>Progress in Retinal and Eye Research</title></titleInfo><titleInfo type="abbreviated"><title>JPRR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">200003</dateIssued></originInfo><identifier type="ISSN">1350-9462</identifier><identifier type="PII">S1350-9462(00)X0019-5</identifier><part><date>200003</date><detail type="volume"><number>19</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>131</start><end>256</end></extent><extent unit="pages"><start>149</start><end>170</end></extent></part></relatedItem><identifier type="istex">AADC67DF27B481E3B03C0F04BF88D69A7E511A50</identifier><identifier type="DOI">10.1016/S1350-9462(99)00013-0</identifier><identifier type="PII">S1350-9462(99)00013-0</identifier><accessCondition type="use and reproduction" contentType="">© 2000Elsevier Science Ltd</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Ltd, ©2000</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/AADC67DF27B481E3B03C0F04BF88D69A7E511A50/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">OPHTHALMOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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