Reality-Based Real-Time Cell Indentation Simulator
Identifieur interne : 000226 ( Hal/Checkpoint ); précédent : 000225; suivant : 000227Reality-Based Real-Time Cell Indentation Simulator
Auteurs : Hamid Ladjal [France] ; Jean-Luc Hanus [France] ; Anand Pillarisetti [États-Unis] ; Carol Keefer [États-Unis] ; Antoine Ferreira [France] ; Jaydev P. Desai [États-Unis]Source :
- IEEE/ASME Transactions on Mechatronics [ 1083-4435 ] ; 2012-04-01.
Abstract
Training simulators that provide realistic visual and haptic feedback during cell indentation tasks are currently inves tigated. Complex cell geometry inherent to biological cells and intricate mechanical properties drive the need for precise mechan ical and numerical modeling to assure accurate cell deformation and force calculations. Advances in alternative finite-element for mulation, such as the mass-tensor approach, have reached a state, where they are applicable to model soft-cell deformation in real time. The geometrical characteristics and the mechanical proper ties of different cells are determined with atomic force microscopy (AFM) indentation. A real-time, haptics-enabled simulator for cell centered indentation has been developed, which utilizes the AFM data (mechanical and geometrical properties of embryonic stem cells) to accurately replicate the indentation task and predict the cell deformation during indentation in real time. This tool can be used as a mechanical marker to characterize the biological state of the cell. The operator is able to feel the change in the stiff ness during cell deformation between fixed and live cells in real time. A comparative study with finite-element simulations using a commercial software and the experimental data demonstrate the effectiveness of the proposed physically based model.
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DOI: 10.1109/TMECH.2010.2091010
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Avenue du Parc Floral - BP 6749 - 45067 Orléans cedex 2</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-orleans.fr/</ref></desc></org></tutelle><tutelle active="#struct-302160" type="indirect"><org type="institution" xml:id="struct-302160" status="VALID"><orgName>ENSI Bourges</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Orléans</settlement><region type="old region" nuts="2">Région Centre</region><region type="region" nuts="2">Centre-Val de Loire</region></placeName><orgName type="university">Université d'Orléans</orgName><orgName type="institution" wicri:auto="newGroup">Centre Val de Loire Université</orgName></affiliation></author><author><name sortKey="P Desai, Jaydev" sort="P Desai, Jaydev" uniqKey="P Desai J" first="Jaydev" last="P. Desai">Jaydev P. Desai</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-175990" status="INCOMING"><orgName>Robotics Center, Institute for Systems Research</orgName><orgName type="acronym">RCISR</orgName><desc><address><addrLine>University of Maryland, College Park, MD 20742 USA</addrLine><country key="US"></country></address></desc><listRelation><relation active="#struct-75866" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-75866" type="direct"><org type="institution" xml:id="struct-75866" status="VALID"><orgName>University of Maryland</orgName><desc><address><addrLine>University of Maryland, College Park, MD 20742, USA</addrLine><country key="US"></country></address><ref type="url">http://www.umd.edu/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author></analytic><idno type="DOI">10.1109/TMECH.2010.2091010</idno><series><title level="j">IEEE/ASME Transactions on Mechatronics</title><idno type="ISSN">1083-4435</idno><imprint><date type="datePub">2012-04-01</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Training simulators that provide realistic visual and haptic feedback during cell indentation tasks are currently inves tigated. Complex cell geometry inherent to biological cells and intricate mechanical properties drive the need for precise mechan ical and numerical modeling to assure accurate cell deformation and force calculations. Advances in alternative finite-element for mulation, such as the mass-tensor approach, have reached a state, where they are applicable to model soft-cell deformation in real time. The geometrical characteristics and the mechanical proper ties of different cells are determined with atomic force microscopy (AFM) indentation. A real-time, haptics-enabled simulator for cell centered indentation has been developed, which utilizes the AFM data (mechanical and geometrical properties of embryonic stem cells) to accurately replicate the indentation task and predict the cell deformation during indentation in real time. This tool can be used as a mechanical marker to characterize the biological state of the cell. The operator is able to feel the change in the stiff ness during cell deformation between fixed and live cells in real time. A comparative study with finite-element simulations using a commercial software and the experimental data demonstrate the effectiveness of the proposed physically based model.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Reality-Based Real-Time Cell Indentation Simulator</title><author role="aut"><persName><forename type="first">Hamid</forename><surname>Ladjal</surname></persName><email>hamid.ladjal@ensi-bourges.fr</email><idno type="idhal">hamid-ladjal</idno><idno type="halauthor">722145</idno><affiliation ref="#struct-388254"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Luc</forename><surname>Hanus</surname></persName><email>Jean-luc.Hanus@ensi-bourges.fr</email><idno type="halauthor">666132</idno><affiliation ref="#struct-388255"></affiliation></author><author role="aut"><persName><forename type="first">Anand</forename><surname>Pillarisetti</surname></persName><email>anandpi@seas.upenn.edu</email><idno type="halauthor">666133</idno><affiliation ref="#struct-175988"></affiliation></author><author role="aut"><persName><forename type="first">Carol</forename><surname>Keefer</surname></persName><email>ckeefer@umd.edu</email><idno type="halauthor">666134</idno><affiliation ref="#struct-175989"></affiliation></author><author role="crp"><persName><forename type="first">Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email><idno type="halauthor">666129</idno><affiliation ref="#struct-388254"></affiliation></author><author role="aut"><persName><forename type="first">Jaydev</forename><surname>P.Desai</surname></persName><email>jaydev@umd.edu</email><idno type="halauthor">666135</idno><affiliation ref="#struct-175990"></affiliation></author><editor role="depositor"><persName><forename>Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email></editor><funder>Contrat CIFRE</funder></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2011-12-03 14:07:28</date><date type="whenModified">2016-03-21 17:27:33</date><date type="whenReleased">2011-12-05 10:21:02</date><date type="whenProduced">2012-04-01</date><date type="whenEndEmbargoed">2011-12-03</date><ref type="file" target="https://hal.archives-ouvertes.fr/hal-00647908/document"><date notBefore="2011-12-03"></date></ref><ref type="file" subtype="greenPublisher" n="1" target="https://hal.archives-ouvertes.fr/hal-00647908/file/TMECH2091010.pdf"><date notBefore="2011-12-03"></date></ref></edition><respStmt><resp>contributor</resp><name key="163161"><persName><forename>Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-00647908</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00647908</idno><idno type="halBibtex">ladjal:hal-00647908</idno><idno type="halRefHtml">IEEE/ASME Transactions on Mechatronics, Institute of Electrical and Electronics Engineers, 2012, 17 (2), pp.239 - 250. <10.1109/TMECH.2010.2091010></idno><idno type="halRef">IEEE/ASME Transactions on Mechatronics, Institute of Electrical and Electronics Engineers, 2012, 17 (2), pp.239 - 250. <10.1109/TMECH.2010.2091010></idno></publicationStmt><seriesStmt><idno type="stamp" n="UNIV-ORLEANS">Université d'Orléans</idno><idno type="stamp" n="MSL">Modelisation Systemes Langages</idno><idno type="stamp" n="PRIMES_WP5" p="PRIMES">WP5: Simulation et modélisation d'images</idno><idno type="stamp" n="PRIMES">Physics, Radiobiology, Medical Imaging, and Simulation (PRIMES)</idno><idno type="stamp" n="MSL-THESE">Modelisation Systemes Langages</idno><idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reality-Based Real-Time Cell Indentation Simulator</title><author role="aut"><persName><forename type="first">Hamid</forename><surname>Ladjal</surname></persName><email>hamid.ladjal@ensi-bourges.fr</email><idno type="idHal">hamid-ladjal</idno><idno type="halAuthorId">722145</idno><affiliation ref="#struct-388254"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Luc</forename><surname>Hanus</surname></persName><email>Jean-luc.Hanus@ensi-bourges.fr</email><idno type="halAuthorId">666132</idno><affiliation ref="#struct-388255"></affiliation></author><author role="aut"><persName><forename type="first">Anand</forename><surname>Pillarisetti</surname></persName><email>anandpi@seas.upenn.edu</email><idno type="halAuthorId">666133</idno><affiliation ref="#struct-175988"></affiliation></author><author role="aut"><persName><forename type="first">Carol</forename><surname>Keefer</surname></persName><email>ckeefer@umd.edu</email><idno type="halAuthorId">666134</idno><affiliation ref="#struct-175989"></affiliation></author><author role="crp"><persName><forename type="first">Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email><idno type="halAuthorId">666129</idno><affiliation ref="#struct-388254"></affiliation></author><author role="aut"><persName><forename type="first">Jaydev</forename><surname>P.Desai</surname></persName><email>jaydev@umd.edu</email><idno type="halAuthorId">666135</idno><affiliation ref="#struct-175990"></affiliation></author></analytic><monogr><idno type="localRef">ROB; DMS</idno><idno type="halJournalId" status="VALID">14081</idno><idno type="issn">1083-4435</idno><title level="j">IEEE/ASME Transactions on Mechatronics</title><imprint><publisher>Institute of Electrical and Electronics Engineers</publisher><biblScope unit="volume">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="pp">239 - 250</biblScope><date type="datePub">2012-04-01</date></imprint></monogr><idno type="doi">10.1109/TMECH.2010.2091010</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="spi.auto">Engineering Sciences [physics]/Automatic</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">Training simulators that provide realistic visual and haptic feedback during cell indentation tasks are currently inves tigated. Complex cell geometry inherent to biological cells and intricate mechanical properties drive the need for precise mechan ical and numerical modeling to assure accurate cell deformation and force calculations. Advances in alternative finite-element for mulation, such as the mass-tensor approach, have reached a state, where they are applicable to model soft-cell deformation in real time. The geometrical characteristics and the mechanical proper ties of different cells are determined with atomic force microscopy (AFM) indentation. A real-time, haptics-enabled simulator for cell centered indentation has been developed, which utilizes the AFM data (mechanical and geometrical properties of embryonic stem cells) to accurately replicate the indentation task and predict the cell deformation during indentation in real time. This tool can be used as a mechanical marker to characterize the biological state of the cell. The operator is able to feel the change in the stiff ness during cell deformation between fixed and live cells in real time. A comparative study with finite-element simulations using a commercial software and the experimental data demonstrate the effectiveness of the proposed physically based model.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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