Identification of a Novel Human Papillomavirus, Type HPV199, Isolated from a Nasopharynx and Anal Canal, and Complete Genomic Characterization of Papillomavirus Species Gamma-12
Identifieur interne : 000007 ( Pmc/Curation ); précédent : 000006; suivant : 000008Identification of a Novel Human Papillomavirus, Type HPV199, Isolated from a Nasopharynx and Anal Canal, and Complete Genomic Characterization of Papillomavirus Species Gamma-12
Auteurs : Anja Oštrbenk [Slovénie] ; Boštjan J. Kocjan [Slovénie] ; Lea Hošnjak [Slovénie] ; Jingjing Li [République populaire de Chine] ; Qiuju Deng [République populaire de Chine] ; Anja Šterbenc [Slovénie] ; Mario Poljak [Slovénie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The novel human papillomavirus type 199 (HPV199) was initially identified in a nasopharyngeal swab sample obtained from a 25 year-old immunocompetent male. The complete genome of HPV199 is 7,184 bp in length with a GC content of 36.5%. Comparative genomic characterization of HPV199 and its closest relatives showed the classical genomic organization of Gammapapillomaviruses (
Url:
DOI: 10.1371/journal.pone.0138628
PubMed: 26375679
PubMed Central: 4574437
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-12</title>
<author><name sortKey="Ostrbenk, Anja" sort="Ostrbenk, Anja" uniqKey="Ostrbenk A" first="Anja" last="Oštrbenk">Anja Oštrbenk</name>
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<author><name sortKey="Kocjan, Bostjan J" sort="Kocjan, Bostjan J" uniqKey="Kocjan B" first="Boštjan J." last="Kocjan">Boštjan J. Kocjan</name>
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<front><div type="abstract" xml:lang="en"><p>The novel human papillomavirus type 199 (HPV199) was initially identified in a nasopharyngeal swab sample obtained from a 25 year-old immunocompetent male. The complete genome of HPV199 is 7,184 bp in length with a GC content of 36.5%. Comparative genomic characterization of HPV199 and its closest relatives showed the classical genomic organization of Gammapapillomaviruses (<italic>Gamma</italic>
-PVs). HPV199 has seven major open reading frames (ORFs), encoding five early (E1, E2, E4, E6, and E7) and two late (L1 and L2) proteins, while lacking the E5 ORF. The long control region (LCR) of 513 bp is located between the L1 and E6 ORFs. Phylogenetic analysis additionally confirmed that HPV-199 clusters into the <italic>Gamma</italic>
-PV genus, species <italic>Gamma</italic>
-12, additionally containing HPV127, HV132, HPV148, HPV165, and three putative HPV types: KC5, CG2 and CG3. HPV199 is most closely related to HPV127 (nucleotide identity 77%). The complete viral genome sequence of additional HPV199 isolate was determined from anal canal swab sample. Two HPV199 complete viral sequences exhibit 99.4% nucleotide identity. To the best of our knowledge, this is the first member of <italic>Gamma</italic>
-PV with complete nucleotide sequences determined from two independent clinical samples. To evaluate the tissue tropism of the novel HPV type, 916 clinical samples were tested using HPV199 type-specific real-time PCR: HPV199 was detected in 2/76 tissue samples of histologically confirmed common warts, 2/108 samples of eyebrow hair follicles, 2/137 anal canal swabs obtained from individuals with clinically evident anal pathology, 4/184 nasopharyngeal swabs and 3/411 cervical swabs obtained from women with normal cervical cytology. Although HPV199 was found in 1.4% of cutaneous and mucosal samples only, it exhibits dual tissue tropism. According to the results of our study and literature data, dual tropism of all <italic>Gamma</italic>
-12 members is highly possible.</p>
</div>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bernard, Hu" uniqKey="Bernard H">HU Bernard</name>
</author>
<author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Van Doorslaer, K" uniqKey="Van Doorslaer K">K van Doorslaer</name>
</author>
<author><name sortKey="Zur Hausen, H" uniqKey="Zur Hausen H">H Zur Hausen</name>
</author>
<author><name sortKey="De Villiers, Em" uniqKey="De Villiers E">EM de Villiers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cubie, Ha" uniqKey="Cubie H">HA Cubie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bzhalava, D" uniqKey="Bzhalava D">D Bzhalava</name>
</author>
<author><name sortKey="Eklund, C" uniqKey="Eklund C">C Eklund</name>
</author>
<author><name sortKey="Dillner, J" uniqKey="Dillner J">J Dillner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bottalico, D" uniqKey="Bottalico D">D Bottalico</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Dunne, A" uniqKey="Dunne A">A Dunne</name>
</author>
<author><name sortKey="Ostoloza, J" uniqKey="Ostoloza J">J Ostoloza</name>
</author>
<author><name sortKey="Mckinney, S" uniqKey="Mckinney S">S McKinney</name>
</author>
<author><name sortKey="Sun, C" uniqKey="Sun C">C Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ure, Ae" uniqKey="Ure A">AE Ure</name>
</author>
<author><name sortKey="Forslund, O" uniqKey="Forslund O">O Forslund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ekstrom, J" uniqKey="Ekstrom J">J Ekström</name>
</author>
<author><name sortKey="Bzhalava, D" uniqKey="Bzhalava D">D Bzhalava</name>
</author>
<author><name sortKey="Svenback, D" uniqKey="Svenback D">D Svenback</name>
</author>
<author><name sortKey="Forslund, O" uniqKey="Forslund O">O Forslund</name>
</author>
<author><name sortKey="Dillner, J" uniqKey="Dillner J">J Dillner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Foulongne, V" uniqKey="Foulongne V">V Foulongne</name>
</author>
<author><name sortKey="Sauvage, V" uniqKey="Sauvage V">V Sauvage</name>
</author>
<author><name sortKey="Hebert, C" uniqKey="Hebert C">C Hebert</name>
</author>
<author><name sortKey="Dereure, O" uniqKey="Dereure O">O Dereure</name>
</author>
<author><name sortKey="Cheval, J" uniqKey="Cheval J">J Cheval</name>
</author>
<author><name sortKey="Gouilh, Ma" uniqKey="Gouilh M">MA Gouilh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name>
</author>
<author><name sortKey="Madupu, R" uniqKey="Madupu R">R Madupu</name>
</author>
<author><name sortKey="Karaoz, U" uniqKey="Karaoz U">U Karaoz</name>
</author>
<author><name sortKey="Nossa, Cw" uniqKey="Nossa C">CW Nossa</name>
</author>
<author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name>
</author>
<author><name sortKey="Yooseph, S" uniqKey="Yooseph S">S Yooseph</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antonsson, A" uniqKey="Antonsson A">A Antonsson</name>
</author>
<author><name sortKey="Erfurt, C" uniqKey="Erfurt C">C Erfurt</name>
</author>
<author><name sortKey="Hazard, K" uniqKey="Hazard K">K Hazard</name>
</author>
<author><name sortKey="Holmgren, V" uniqKey="Holmgren V">V Holmgren</name>
</author>
<author><name sortKey="Simon, M" uniqKey="Simon M">M Simon</name>
</author>
<author><name sortKey="Kataoka, A" uniqKey="Kataoka A">A Kataoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sichero, L" uniqKey="Sichero L">L Sichero</name>
</author>
<author><name sortKey="Pierce Campbell, Cm" uniqKey="Pierce Campbell C">CM Pierce Campbell</name>
</author>
<author><name sortKey="Ferreira, S" uniqKey="Ferreira S">S Ferreira</name>
</author>
<author><name sortKey="Sobrinho, Js" uniqKey="Sobrinho J">JS Sobrinho</name>
</author>
<author><name sortKey="Luiza Baggio, M" uniqKey="Luiza Baggio M">M Luiza Baggio</name>
</author>
<author><name sortKey="Galan, L" uniqKey="Galan L">L Galan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forslund, O" uniqKey="Forslund O">O Forslund</name>
</author>
<author><name sortKey="Johansson, H" uniqKey="Johansson H">H Johansson</name>
</author>
<author><name sortKey="Madsen, Kg" uniqKey="Madsen K">KG Madsen</name>
</author>
<author><name sortKey="Kofoed, K" uniqKey="Kofoed K">K Kofoed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sichero, L" uniqKey="Sichero L">L Sichero</name>
</author>
<author><name sortKey="Nyitray, Ag" uniqKey="Nyitray A">AG Nyitray</name>
</author>
<author><name sortKey="Nunes, Em" uniqKey="Nunes E">EM Nunes</name>
</author>
<author><name sortKey="Nepal, B" uniqKey="Nepal B">B Nepal</name>
</author>
<author><name sortKey="Ferreira, S" uniqKey="Ferreira S">S Ferreira</name>
</author>
<author><name sortKey="Sobrinho, Js" uniqKey="Sobrinho J">JS Sobrinho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Seme, K" uniqKey="Seme K">K Seme</name>
</author>
<author><name sortKey="Poto Nik, M" uniqKey="Poto Nik M">M Potočnik</name>
</author>
<author><name sortKey="Fujs, K" uniqKey="Fujs K">K Fujs</name>
</author>
<author><name sortKey="Babic, Dz" uniqKey="Babic D">DZ Babic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Odar, K" uniqKey="Odar K">K Odar</name>
</author>
<author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Hosnjak, L" uniqKey="Hosnjak L">L Hošnjak</name>
</author>
<author><name sortKey="Gale, N" uniqKey="Gale N">N Gale</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Zidar, N" uniqKey="Zidar N">N Zidar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forslund, O" uniqKey="Forslund O">O Forslund</name>
</author>
<author><name sortKey="Antonsson, A" uniqKey="Antonsson A">A Antonsson</name>
</author>
<author><name sortKey="Nordin, P" uniqKey="Nordin P">P Nordin</name>
</author>
<author><name sortKey="Stenquist, B" uniqKey="Stenquist B">B Stenquist</name>
</author>
<author><name sortKey="Hansson, Bg" uniqKey="Hansson B">BG Hansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forslund, O" uniqKey="Forslund O">O Forslund</name>
</author>
<author><name sortKey="Ly, H" uniqKey="Ly H">H Ly</name>
</author>
<author><name sortKey="Higgins, G" uniqKey="Higgins G">G Higgins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name>
</author>
<author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Hang, D" uniqKey="Hang D">D Hang</name>
</author>
<author><name sortKey="Shen, N" uniqKey="Shen N">N Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hall, Ta" uniqKey="Hall T">TA Hall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rector, A" uniqKey="Rector A">A Rector</name>
</author>
<author><name sortKey="Tachezy, R" uniqKey="Tachezy R">R Tachezy</name>
</author>
<author><name sortKey="Van Ranst, M" uniqKey="Van Ranst M">M Van Ranst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Platt, Ar" uniqKey="Platt A">AR Platt</name>
</author>
<author><name sortKey="Woodhall, Rw" uniqKey="Woodhall R">RW Woodhall</name>
</author>
<author><name sortKey="George, Al" uniqKey="George A">AL George</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name>
</author>
<author><name sortKey="Filipski, A" uniqKey="Filipski A">A Filipski</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hosnjak, L" uniqKey="Hosnjak L">L Hošnjak</name>
</author>
<author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Pirs, B" uniqKey="Pirs B">B Pirš</name>
</author>
<author><name sortKey="Seme, K" uniqKey="Seme K">K Seme</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Doorslaer, K" uniqKey="Van Doorslaer K">K Van Doorslaer</name>
</author>
<author><name sortKey="Tan, Q" uniqKey="Tan Q">Q Tan</name>
</author>
<author><name sortKey="Xirasagar, S" uniqKey="Xirasagar S">S Xirasagar</name>
</author>
<author><name sortKey="Bandaru, S" uniqKey="Bandaru S">S Bandaru</name>
</author>
<author><name sortKey="Gopalan, V" uniqKey="Gopalan V">V Gopalan</name>
</author>
<author><name sortKey="Mohamoud, Y" uniqKey="Mohamoud Y">Y Mohamoud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Schiffman, M" uniqKey="Schiffman M">M Schiffman</name>
</author>
<author><name sortKey="Herrero, R" uniqKey="Herrero R">R Herrero</name>
</author>
<author><name sortKey="Desalle, R" uniqKey="Desalle R">R Desalle</name>
</author>
<author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bao, Y" uniqKey="Bao Y">Y Bao</name>
</author>
<author><name sortKey="Chetvernin, V" uniqKey="Chetvernin V">V Chetvernin</name>
</author>
<author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Terai, M" uniqKey="Terai M">M Terai</name>
</author>
<author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Schiffman, M" uniqKey="Schiffman M">M Schiffman</name>
</author>
<author><name sortKey="Herrero, R" uniqKey="Herrero R">R Herrero</name>
</author>
<author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Seme, K" uniqKey="Seme K">K Seme</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Milosevi, M" uniqKey="Milosevi M">M Milošević</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Mlakar, B" uniqKey="Mlakar B">B Mlakar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujs Komlos, K" uniqKey="Fujs Komlos K">K Fujs Komloš</name>
</author>
<author><name sortKey="Kosorok, P" uniqKey="Kosorok P">P Košorok</name>
</author>
<author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Ostrbenk, A" uniqKey="Ostrbenk A">A Ostrbenk</name>
</author>
<author><name sortKey="Seme, K" uniqKey="Seme K">K Seme</name>
</author>
<author><name sortKey="Ucakar, V" uniqKey="Ucakar V">V Ucakar</name>
</author>
<author><name sortKey="Hillemanns, P" uniqKey="Hillemanns P">P Hillemanns</name>
</author>
<author><name sortKey="Bokal, Ev" uniqKey="Bokal E">EV Bokal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Duin, M" uniqKey="Van Duin M">M van Duin</name>
</author>
<author><name sortKey="Snijders, Pj" uniqKey="Snijders P">PJ Snijders</name>
</author>
<author><name sortKey="Schrijnemakers, Hf" uniqKey="Schrijnemakers H">HF Schrijnemakers</name>
</author>
<author><name sortKey="Voorhorst, Fj" uniqKey="Voorhorst F">FJ Voorhorst</name>
</author>
<author><name sortKey="Rozendaal, L" uniqKey="Rozendaal L">L Rozendaal</name>
</author>
<author><name sortKey="Nobbenhuis, Ma" uniqKey="Nobbenhuis M">MA Nobbenhuis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poto Nik, M" uniqKey="Poto Nik M">M Potočnik</name>
</author>
<author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Seme, K" uniqKey="Seme K">K Seme</name>
</author>
<author><name sortKey="Luzar, B" uniqKey="Luzar B">B Luzar</name>
</author>
<author><name sortKey="Babi, Dz" uniqKey="Babi D">DZ Babič</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasher, Ms" uniqKey="Kasher M">MS Kasher</name>
</author>
<author><name sortKey="Roman, A" uniqKey="Roman A">A Roman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heinzel, Pa" uniqKey="Heinzel P">PA Heinzel</name>
</author>
<author><name sortKey="Chan, Sy" uniqKey="Chan S">SY Chan</name>
</author>
<author><name sortKey="Ho, L" uniqKey="Ho L">L Ho</name>
</author>
<author><name sortKey="O Connor, M" uniqKey="O Connor M">M O'Connor</name>
</author>
<author><name sortKey="Balaram, P" uniqKey="Balaram P">P Balaram</name>
</author>
<author><name sortKey="Campo, Ms" uniqKey="Campo M">MS Campo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Cimerman, M" uniqKey="Cimerman M">M Cimerman</name>
</author>
<author><name sortKey="Gale, N" uniqKey="Gale N">N Gale</name>
</author>
<author><name sortKey="Potocnik, M" uniqKey="Potocnik M">M Potocnik</name>
</author>
<author><name sortKey="Bogovac, Z" uniqKey="Bogovac Z">Z Bogovac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Venuti, A" uniqKey="Venuti A">A Venuti</name>
</author>
<author><name sortKey="Paolini, F" uniqKey="Paolini F">F Paolini</name>
</author>
<author><name sortKey="Nasir, L" uniqKey="Nasir L">L Nasir</name>
</author>
<author><name sortKey="Corteggio, A" uniqKey="Corteggio A">A Corteggio</name>
</author>
<author><name sortKey="Roperto, S" uniqKey="Roperto S">S Roperto</name>
</author>
<author><name sortKey="Campo, Ms" uniqKey="Campo M">MS Campo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narechania, A" uniqKey="Narechania A">A Narechania</name>
</author>
<author><name sortKey="Terai, M" uniqKey="Terai M">M Terai</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Desalle, R" uniqKey="Desalle R">R DeSalle</name>
</author>
<author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name>
</author>
<author><name sortKey="Tomita, Y" uniqKey="Tomita Y">Y Tomita</name>
</author>
<author><name sortKey="Okada, M" uniqKey="Okada M">M Okada</name>
</author>
<author><name sortKey="Shirasawa, H" uniqKey="Shirasawa H">H Shirasawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roman, A" uniqKey="Roman A">A Roman</name>
</author>
<author><name sortKey="Munger, K" uniqKey="Munger K">K Munger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mclaughlin Drubin, Me" uniqKey="Mclaughlin Drubin M">ME McLaughlin-Drubin</name>
</author>
<author><name sortKey="Munger, K" uniqKey="Munger K">K Münger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitsuishi, T" uniqKey="Mitsuishi T">T Mitsuishi</name>
</author>
<author><name sortKey="Ohsawa, I" uniqKey="Ohsawa I">I Ohsawa</name>
</author>
<author><name sortKey="Kato, T" uniqKey="Kato T">T Kato</name>
</author>
<author><name sortKey="Egawa, N" uniqKey="Egawa N">N Egawa</name>
</author>
<author><name sortKey="Kiyono, T" uniqKey="Kiyono T">T Kiyono</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kohler, A" uniqKey="Kohler A">A Köhler</name>
</author>
<author><name sortKey="Gottschling, M" uniqKey="Gottschling M">M Gottschling</name>
</author>
<author><name sortKey="Manning, K" uniqKey="Manning K">K Manning</name>
</author>
<author><name sortKey="Lehmann, M" uniqKey="Lehmann M">M Lehmann</name>
</author>
<author><name sortKey="Schulz, E" uniqKey="Schulz E">E Schulz</name>
</author>
<author><name sortKey="Kruger Corcoran, D" uniqKey="Kruger Corcoran D">D Krüger-Corcoran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Titolo, S" uniqKey="Titolo S">S Titolo</name>
</author>
<author><name sortKey="Pelletier, A" uniqKey="Pelletier A">A Pelletier</name>
</author>
<author><name sortKey="Sauve, F" uniqKey="Sauve F">F Sauvé</name>
</author>
<author><name sortKey="Brault, K" uniqKey="Brault K">K Brault</name>
</author>
<author><name sortKey="Wardrop, E" uniqKey="Wardrop E">E Wardrop</name>
</author>
<author><name sortKey="White, Pw" uniqKey="White P">PW White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bergvall, M" uniqKey="Bergvall M">M Bergvall</name>
</author>
<author><name sortKey="Melendy, T" uniqKey="Melendy T">T Melendy</name>
</author>
<author><name sortKey="Archambault, J" uniqKey="Archambault J">J Archambault</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, N" uniqKey="Zou N">N Zou</name>
</author>
<author><name sortKey="Lin, By" uniqKey="Lin B">BY Lin</name>
</author>
<author><name sortKey="Duan, F" uniqKey="Duan F">F Duan</name>
</author>
<author><name sortKey="Lee, Ky" uniqKey="Lee K">KY Lee</name>
</author>
<author><name sortKey="Jin, G" uniqKey="Jin G">G Jin</name>
</author>
<author><name sortKey="Guan, R" uniqKey="Guan R">R Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doorbar, J" uniqKey="Doorbar J">J Doorbar</name>
</author>
<author><name sortKey="Myers, G" uniqKey="Myers G">G Myers</name>
</author>
<author><name sortKey="Myers, G" uniqKey="Myers G">G Myers</name>
</author>
<author><name sortKey="Halpern, A" uniqKey="Halpern A">A Halpern</name>
</author>
<author><name sortKey="Baker, C" uniqKey="Baker C">C Baker</name>
</author>
<author><name sortKey="Mcbride, A" uniqKey="Mcbride A">A McBride</name>
</author>
<author><name sortKey="Wheeler, C" uniqKey="Wheeler C">C Wheeler</name>
</author>
<author><name sortKey="Doorbar, J" uniqKey="Doorbar J">J Doorbar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kovanda, A" uniqKey="Kovanda A">A Kovanda</name>
</author>
<author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Poto Nik, M" uniqKey="Poto Nik M">M Potočnik</name>
</author>
<author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Doorbar, J" uniqKey="Doorbar J">J Doorbar</name>
</author>
<author><name sortKey="Sun, Xy" uniqKey="Sun X">XY Sun</name>
</author>
<author><name sortKey="Crawford, Lv" uniqKey="Crawford L">LV Crawford</name>
</author>
<author><name sortKey="Mclean, Cs" uniqKey="Mclean C">CS McLean</name>
</author>
<author><name sortKey="Frazer, Ih" uniqKey="Frazer I">IH Frazer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, Lm" uniqKey="Nelson L">LM Nelson</name>
</author>
<author><name sortKey="Rose, Rc" uniqKey="Rose R">RC Rose</name>
</author>
<author><name sortKey="Leroux, L" uniqKey="Leroux L">L LeRoux</name>
</author>
<author><name sortKey="Lane, C" uniqKey="Lane C">C Lane</name>
</author>
<author><name sortKey="Bruya, K" uniqKey="Bruya K">K Bruya</name>
</author>
<author><name sortKey="Moroianu, J" uniqKey="Moroianu J">J Moroianu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Jw" uniqKey="Wang J">JW Wang</name>
</author>
<author><name sortKey="Roden, Rb" uniqKey="Roden R">RB Roden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buck, Cb" uniqKey="Buck C">CB Buck</name>
</author>
<author><name sortKey="Day, Pm" uniqKey="Day P">PM Day</name>
</author>
<author><name sortKey="Trus, Bl" uniqKey="Trus B">BL Trus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bronnimann, Mp" uniqKey="Bronnimann M">MP Bronnimann</name>
</author>
<author><name sortKey="Chapman, Ja" uniqKey="Chapman J">JA Chapman</name>
</author>
<author><name sortKey="Park, Ck" uniqKey="Park C">CK Park</name>
</author>
<author><name sortKey="Campos, Sk" uniqKey="Campos S">SK Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Onnor, M" uniqKey="O Onnor M">M O’Connor</name>
</author>
<author><name sortKey="Chan, Sy" uniqKey="Chan S">SY Chan</name>
</author>
<author><name sortKey="Bernard, Hu" uniqKey="Bernard H">HU Bernard</name>
</author>
<author><name sortKey="Myers, G" uniqKey="Myers G">G Myers</name>
</author>
<author><name sortKey="Bernard, Hu" uniqKey="Bernard H">HU Bernard</name>
</author>
<author><name sortKey="Delius, H" uniqKey="Delius H">H Delius</name>
</author>
<author><name sortKey="Baker, C" uniqKey="Baker C">C Baker</name>
</author>
<author><name sortKey="Icenogle, J" uniqKey="Icenogle J">J Icenogle</name>
</author>
<author><name sortKey="Halpern, A" uniqKey="Halpern A">A Halpern</name>
</author>
<author><name sortKey="Wheeler, C" uniqKey="Wheeler C">C Wheeler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernard, Hu" uniqKey="Bernard H">HU Bernard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schowalter, Rm" uniqKey="Schowalter R">RM Schowalter</name>
</author>
<author><name sortKey="Pastrana, Dv" uniqKey="Pastrana D">DV Pastrana</name>
</author>
<author><name sortKey="Pumphrey, Ka" uniqKey="Pumphrey K">KA Pumphrey</name>
</author>
<author><name sortKey="Moyer, Al" uniqKey="Moyer A">AL Moyer</name>
</author>
<author><name sortKey="Buck, Cb" uniqKey="Buck C">CB Buck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name>
</author>
<author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Hang, D" uniqKey="Hang D">D Hang</name>
</author>
<author><name sortKey="Shen, N" uniqKey="Shen N">N Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torres, M" uniqKey="Torres M">M Torres</name>
</author>
<author><name sortKey="Gheit, T" uniqKey="Gheit T">T Gheit</name>
</author>
<author><name sortKey="Mckay Chopin, S" uniqKey="Mckay Chopin S">S McKay-Chopin</name>
</author>
<author><name sortKey="Rodriguez, C" uniqKey="Rodriguez C">C Rodríguez</name>
</author>
<author><name sortKey="Romero, Jd" uniqKey="Romero J">JD Romero</name>
</author>
<author><name sortKey="Filotico, R" uniqKey="Filotico R">R Filotico</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nordin, P" uniqKey="Nordin P">P Nordin</name>
</author>
<author><name sortKey="Hansson, Bg" uniqKey="Hansson B">BG Hansson</name>
</author>
<author><name sortKey="Hansson, C" uniqKey="Hansson C">C Hansson</name>
</author>
<author><name sortKey="Blohme, I" uniqKey="Blohme I">I Blohmè</name>
</author>
<author><name sortKey="Larko, O" uniqKey="Larko O">O Larkö</name>
</author>
<author><name sortKey="Andersson, K" uniqKey="Andersson K">K Andersson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antonsson, A" uniqKey="Antonsson A">A Antonsson</name>
</author>
<author><name sortKey="Forslund, O" uniqKey="Forslund O">O Forslund</name>
</author>
<author><name sortKey="Ekberg, H" uniqKey="Ekberg H">H Ekberg</name>
</author>
<author><name sortKey="Sterner, G" uniqKey="Sterner G">G Sterner</name>
</author>
<author><name sortKey="Hansson, Bg" uniqKey="Hansson B">BG Hansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chouhy, D" uniqKey="Chouhy D">D Chouhy</name>
</author>
<author><name sortKey="Bolatti, Em" uniqKey="Bolatti E">EM Bolatti</name>
</author>
<author><name sortKey="Piccirilli, G" uniqKey="Piccirilli G">G Piccirilli</name>
</author>
<author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sánchez</name>
</author>
<author><name sortKey="Fernandez Bussy, R" uniqKey="Fernandez Bussy R">R Fernandez Bussy</name>
</author>
<author><name sortKey="Giri, Aa" uniqKey="Giri A">AA Giri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harwood, Ca" uniqKey="Harwood C">CA Harwood</name>
</author>
<author><name sortKey="Spink, Pj" uniqKey="Spink P">PJ Spink</name>
</author>
<author><name sortKey="Surentheran, T" uniqKey="Surentheran T">T Surentheran</name>
</author>
<author><name sortKey="Leigh, Im" uniqKey="Leigh I">IM Leigh</name>
</author>
<author><name sortKey="De Villiers, Em" uniqKey="De Villiers E">EM de Villiers</name>
</author>
<author><name sortKey="Mcgregor, Jm" uniqKey="Mcgregor J">JM McGregor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kohler, A" uniqKey="Kohler A">A Köhler</name>
</author>
<author><name sortKey="Meyer, T" uniqKey="Meyer T">T Meyer</name>
</author>
<author><name sortKey="Stockfleth, E" uniqKey="Stockfleth E">E Stockfleth</name>
</author>
<author><name sortKey="Nindl, I" uniqKey="Nindl I">I Nindl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Obalek, S" uniqKey="Obalek S">S Obalek</name>
</author>
<author><name sortKey="Favre, M" uniqKey="Favre M">M Favre</name>
</author>
<author><name sortKey="Szymanczyk, J" uniqKey="Szymanczyk J">J Szymanczyk</name>
</author>
<author><name sortKey="Misiewicz, J" uniqKey="Misiewicz J">J Misiewicz</name>
</author>
<author><name sortKey="Jablonska, S" uniqKey="Jablonska S">S Jablonska</name>
</author>
<author><name sortKey="Orth, G" uniqKey="Orth G">G Orth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shamanin, V" uniqKey="Shamanin V">V Shamanin</name>
</author>
<author><name sortKey="Delius, H" uniqKey="Delius H">H Delius</name>
</author>
<author><name sortKey="De Villiers, Em" uniqKey="De Villiers E">EM de Villiers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boxman, Il" uniqKey="Boxman I">IL Boxman</name>
</author>
<author><name sortKey="Berkhout, Rj" uniqKey="Berkhout R">RJ Berkhout</name>
</author>
<author><name sortKey="Mulder, Lh" uniqKey="Mulder L">LH Mulder</name>
</author>
<author><name sortKey="Wolkers, Mc" uniqKey="Wolkers M">MC Wolkers</name>
</author>
<author><name sortKey="Bouwes Bavinck, Jn" uniqKey="Bouwes Bavinck J">JN Bouwes Bavinck</name>
</author>
<author><name sortKey="Vermeer, Bj" uniqKey="Vermeer B">BJ Vermeer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boxman, Il" uniqKey="Boxman I">IL Boxman</name>
</author>
<author><name sortKey="Hogewoning, A" uniqKey="Hogewoning A">A Hogewoning</name>
</author>
<author><name sortKey="Mulder, Lh" uniqKey="Mulder L">LH Mulder</name>
</author>
<author><name sortKey="Bouwes Bavinck, Jn" uniqKey="Bouwes Bavinck J">JN Bouwes Bavinck</name>
</author>
<author><name sortKey="Ter Schegget, J" uniqKey="Ter Schegget J">J ter Schegget</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poljak, M" uniqKey="Poljak M">M Poljak</name>
</author>
<author><name sortKey="Kocjan, Bj" uniqKey="Kocjan B">BJ Kocjan</name>
</author>
<author><name sortKey="Poto Nik, M" uniqKey="Poto Nik M">M Potočnik</name>
</author>
<author><name sortKey="Seme, K" uniqKey="Seme K">K Seme</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nobre, Rj" uniqKey="Nobre R">RJ Nobre</name>
</author>
<author><name sortKey="Herraez Hernandez, E" uniqKey="Herraez Hernandez E">E Herráez-Hernández</name>
</author>
<author><name sortKey="Fei, Jw" uniqKey="Fei J">JW Fei</name>
</author>
<author><name sortKey="Langbein, L" uniqKey="Langbein L">L Langbein</name>
</author>
<author><name sortKey="Kaden, S" uniqKey="Kaden S">S Kaden</name>
</author>
<author><name sortKey="Grone, Hj" uniqKey="Grone H">HJ Gröne</name>
</author>
</analytic>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26375679</article-id>
<article-id pub-id-type="pmc">4574437</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0138628</article-id>
<article-id pub-id-type="publisher-id">PONE-D-15-24087</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Identification of a Novel Human Papillomavirus, Type HPV199, Isolated from a Nasopharynx and Anal Canal, and Complete Genomic Characterization of Papillomavirus Species <italic>Gamma</italic>
-12</article-title>
<alt-title alt-title-type="running-head">Identification of HPV199 and Characterization of <italic>Gamma</italic>
PV-12 Species</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Oštrbenk</surname>
<given-names>Anja</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kocjan</surname>
<given-names>Boštjan J.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hošnjak</surname>
<given-names>Lea</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Jingjing</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deng</surname>
<given-names>Qiuju</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Šterbenc</surname>
<given-names>Anja</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poljak</surname>
<given-names>Mario</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Angeletti</surname>
<given-names>Peter C.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>University of Nebraska-Lincoln, UNITED STATES</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: AO LH BJK MP. Performed the experiments: AO LH AŠ JL QD. Analyzed the data: AO LH AŠ BJK. Contributed reagents/materials/analysis tools: MP JL QD. Wrote the paper: AO AŠ BJK MP.</p>
</fn>
<corresp id="cor001">* E-mail: <email>mario.poljak@mf.uni-lj.si</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>16</day>
<month>9</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>9</issue>
<elocation-id>e0138628</elocation-id>
<history><date date-type="received"><day>3</day>
<month>6</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>31</day>
<month>8</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-year>2015</copyright-year>
<copyright-holder>Oštrbenk et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0138628.pdf"></self-uri>
<abstract><p>The novel human papillomavirus type 199 (HPV199) was initially identified in a nasopharyngeal swab sample obtained from a 25 year-old immunocompetent male. The complete genome of HPV199 is 7,184 bp in length with a GC content of 36.5%. Comparative genomic characterization of HPV199 and its closest relatives showed the classical genomic organization of Gammapapillomaviruses (<italic>Gamma</italic>
-PVs). HPV199 has seven major open reading frames (ORFs), encoding five early (E1, E2, E4, E6, and E7) and two late (L1 and L2) proteins, while lacking the E5 ORF. The long control region (LCR) of 513 bp is located between the L1 and E6 ORFs. Phylogenetic analysis additionally confirmed that HPV-199 clusters into the <italic>Gamma</italic>
-PV genus, species <italic>Gamma</italic>
-12, additionally containing HPV127, HV132, HPV148, HPV165, and three putative HPV types: KC5, CG2 and CG3. HPV199 is most closely related to HPV127 (nucleotide identity 77%). The complete viral genome sequence of additional HPV199 isolate was determined from anal canal swab sample. Two HPV199 complete viral sequences exhibit 99.4% nucleotide identity. To the best of our knowledge, this is the first member of <italic>Gamma</italic>
-PV with complete nucleotide sequences determined from two independent clinical samples. To evaluate the tissue tropism of the novel HPV type, 916 clinical samples were tested using HPV199 type-specific real-time PCR: HPV199 was detected in 2/76 tissue samples of histologically confirmed common warts, 2/108 samples of eyebrow hair follicles, 2/137 anal canal swabs obtained from individuals with clinically evident anal pathology, 4/184 nasopharyngeal swabs and 3/411 cervical swabs obtained from women with normal cervical cytology. Although HPV199 was found in 1.4% of cutaneous and mucosal samples only, it exhibits dual tissue tropism. According to the results of our study and literature data, dual tropism of all <italic>Gamma</italic>
-12 members is highly possible.</p>
</abstract>
<funding-group><funding-statement>This work is the result of PhD research and is financially supported by the Slovenian Research Agency (ARRS), which funded AO through the Young Researcher Training Program, and in part by the CoheaHr Project (European Commission FP7 Program, grant number: 603019) (MP). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="2"></table-count>
<page-count count="18"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
</record>
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