HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients
Identifieur interne : 000015 ( Main/Merge ); précédent : 000014; suivant : 000016HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients
Auteurs : Bianca Rivera-Pe A [Porto Rico] ; Francisco J. Ruíz-Fullana [Porto Rico] ; Germán L. Vélez-Reyes [Porto Rico] ; Rosa J. Rodriguez-Benitez [Porto Rico] ; María J. Marcos-Martínez [Porto Rico] ; Juan Trinidad-Pinedo [Porto Rico] ; Adriana Báez [Porto Rico]Source :
- Infectious Agents and Cancer [ 1750-9378 ] ; 2016.
Abstract
HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients.
HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher’s exact test and x2. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis.
OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (
HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.
Url:
DOI: 10.1186/s13027-016-0095-4
PubMed: 27559359
PubMed Central: 4995614
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PMC:4995614Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients</title>
<author><name sortKey="Rivera Pe A, Bianca" sort="Rivera Pe A, Bianca" uniqKey="Rivera Pe A B" first="Bianca" last="Rivera-Pe A">Bianca Rivera-Pe A</name>
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<author><name sortKey="Rodriguez Benitez, Rosa J" sort="Rodriguez Benitez, Rosa J" uniqKey="Rodriguez Benitez R" first="Rosa J." last="Rodriguez-Benitez">Rosa J. Rodriguez-Benitez</name>
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<author><name sortKey="Marcos Martinez, Maria J" sort="Marcos Martinez, Maria J" uniqKey="Marcos Martinez M" first="María J." last="Marcos-Martínez">María J. Marcos-Martínez</name>
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<author><name sortKey="Trinidad Pinedo, Juan" sort="Trinidad Pinedo, Juan" uniqKey="Trinidad Pinedo J" first="Juan" last="Trinidad-Pinedo">Juan Trinidad-Pinedo</name>
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<author><name sortKey="Baez, Adriana" sort="Baez, Adriana" uniqKey="Baez A" first="Adriana" last="Báez">Adriana Báez</name>
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<series><title level="j">Infectious Agents and Cancer</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients.</p>
</sec>
<sec><title>Methods</title>
<p>HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher’s exact test and x<sup>2</sup>
. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis.</p>
</sec>
<sec><title>Results</title>
<p>OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (<italic>P</italic>
= 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival.</p>
</sec>
<sec><title>Conclusions</title>
<p>HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.</p>
</sec>
</div>
</front>
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