HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients
Identifieur interne : 000015 ( Main/Merge ); précédent : 000014; suivant : 000016HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients
Auteurs : Bianca Rivera-Pe A [Porto Rico] ; Francisco J. Ruíz-Fullana [Porto Rico] ; Germán L. Vélez-Reyes [Porto Rico] ; Rosa J. Rodriguez-Benitez [Porto Rico] ; María J. Marcos-Martínez [Porto Rico] ; Juan Trinidad-Pinedo [Porto Rico] ; Adriana Báez [Porto Rico]Source :
- Infectious Agents and Cancer [ 1750-9378 ] ; 2016.
Abstract
HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients.
HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher’s exact test and x2. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis.
OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (
HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.
Url:
DOI: 10.1186/s13027-016-0095-4
PubMed: 27559359
PubMed Central: 4995614
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients</title><author><name sortKey="Rivera Pe A, Bianca" sort="Rivera Pe A, Bianca" uniqKey="Rivera Pe A B" first="Bianca" last="Rivera-Pe A">Bianca Rivera-Pe A</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biology, Natural Sciences Faculty, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Biology, Natural Sciences Faculty, University of Puerto Rico, Rio Piedras Campus, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Ruiz Fullana, Francisco J" sort="Ruiz Fullana, Francisco J" uniqKey="Ruiz Fullana F" first="Francisco J." last="Ruíz-Fullana">Francisco J. Ruíz-Fullana</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, 00936 Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Velez Reyes, German L" sort="Velez Reyes, German L" uniqKey="Velez Reyes G" first="Germán L." last="Vélez-Reyes">Germán L. 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Ruíz-Fullana</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, 00936 Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Velez Reyes, German L" sort="Velez Reyes, German L" uniqKey="Velez Reyes G" first="Germán L." last="Vélez-Reyes">Germán L. Vélez-Reyes</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biology, Natural Sciences Faculty, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Biology, Natural Sciences Faculty, University of Puerto Rico, Rio Piedras Campus, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Benitez, Rosa J" sort="Rodriguez Benitez, Rosa J" uniqKey="Rodriguez Benitez R" first="Rosa J." last="Rodriguez-Benitez">Rosa J. Rodriguez-Benitez</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of General Social Sciences, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of General Social Sciences, University of Puerto Rico, Rio Piedras Campus, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Marcos Martinez, Maria J" sort="Marcos Martinez, Maria J" uniqKey="Marcos Martinez M" first="María J." last="Marcos-Martínez">María J. Marcos-Martínez</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Pathology and Laboratory Medicine, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Puerto Rico, School of Medicine, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5">Medical Services Administration, San Juan, Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Medical Services Administration, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Trinidad Pinedo, Juan" sort="Trinidad Pinedo, Juan" uniqKey="Trinidad Pinedo J" first="Juan" last="Trinidad-Pinedo">Juan Trinidad-Pinedo</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, 00936 Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Baez, Adriana" sort="Baez, Adriana" uniqKey="Baez A" first="Adriana" last="Báez">Adriana Báez</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, 00936 Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery Section, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Pharmacology and Toxicology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico</nlm:aff><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Department of Pharmacology and Toxicology, University of Puerto Rico, School of Medicine, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infectious Agents and Cancer</title><idno type="eISSN">1750-9378</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients.</p></sec><sec><title>Methods</title><p>HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher’s exact test and x<sup>2</sup>. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis.</p></sec><sec><title>Results</title><p>OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (<italic>P</italic> = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival.</p></sec><sec><title>Conclusions</title><p>HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Orke, Ma" uniqKey="O Orke M">MA O’Rorke</name></author><author><name sortKey="Ellison, Mv" uniqKey="Ellison M">MV Ellison</name></author><author><name sortKey="Murray, Lj" uniqKey="Murray L">LJ Murray</name></author><author><name sortKey="Moran, M" 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Tribius</name></author><author><name sortKey="Grob, Tj" uniqKey="Grob T">TJ Grob</name></author><author><name sortKey="Meyer, F" uniqKey="Meyer F">F Meyer</name></author><author><name sortKey="Busch, Cj" uniqKey="Busch C">CJ Busch</name></author><author><name sortKey="Petersen, C" uniqKey="Petersen C">C Petersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Em" uniqKey="Smith E">EM Smith</name></author><author><name sortKey="Rubenstein, Lm" uniqKey="Rubenstein L">LM Rubenstein</name></author><author><name sortKey="Haugen, Th" uniqKey="Haugen T">TH Haugen</name></author><author><name sortKey="Pawlita, M" uniqKey="Pawlita M">M Pawlita</name></author><author><name sortKey="Turek, Lp" uniqKey="Turek L">LP Turek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Rj" uniqKey="Young R">RJ Young</name></author><author><name sortKey="Rischin, D" uniqKey="Rischin D">D Rischin</name></author><author><name sortKey="Fisher, R" uniqKey="Fisher R">R Fisher</name></author><author><name sortKey="Mcarthur, Ga" uniqKey="Mcarthur G">GA McArthur</name></author><author><name sortKey="Fox, Sb" uniqKey="Fox S">SB Fox</name></author><author><name sortKey="Peters, Lj" uniqKey="Peters L">LJ Peters</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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