Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach
Identifieur interne : 000374 ( Ncbi/Curation ); précédent : 000373; suivant : 000375Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach
Auteurs : Eric S. J. Harris [États-Unis] ; Shugeng Cao [États-Unis] ; Sean D. Schoville [France] ; Chengming Dong [République populaire de Chine] ; Wenquan Wang [République populaire de Chine] ; Zaiyou Jian [République populaire de Chine] ; Zhongzhen Zhao [République populaire de Chine] ; David M. Eisenberg [États-Unis] ; Jon Clardy [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Oridonin is a diterpenoid with anti-cancer activity that occurs in the Chinese medicinal plant
Url:
DOI: 10.1371/journal.pone.0050753
PubMed: 23209822
PubMed Central: 3507737
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000615
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000615
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000381
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000374
Links to Exploration step
PMC:3507737Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Selection for High Oridonin Yield in the Chinese Medicinal Plant <italic>Isodon</italic>
(Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach</title>
<author><name sortKey="Harris, Eric S J" sort="Harris, Eric S J" uniqKey="Harris E" first="Eric S. J." last="Harris">Eric S. J. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Osher Research Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cao, Shugeng" sort="Cao, Shugeng" uniqKey="Cao S" first="Shugeng" last="Cao">Shugeng Cao</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Osher Research Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schoville, Sean D" sort="Schoville, Sean D" uniqKey="Schoville S" first="Sean D." last="Schoville">Sean D. Schoville</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Université Joseph Fourier Grenoble, Centre National de la Recherche Scientifique TIMC-IMAG UMR 5525, Equipe Biologie Computationnelle et Mathématique, Grenoble, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Joseph Fourier Grenoble, Centre National de la Recherche Scientifique TIMC-IMAG UMR 5525, Equipe Biologie Computationnelle et Mathématique, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dong, Chengming" sort="Dong, Chengming" uniqKey="Dong C" first="Chengming" last="Dong">Chengming Dong</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>College of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan</wicri:regionArea>
<wicri:noRegion>Henan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Wenquan" sort="Wang, Wenquan" uniqKey="Wang W" first="Wenquan" last="Wang">Wenquan Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>School of Chinese Pharmacy, Beijing University of Chinese Medicine, Chaoyang District Beijing, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Chinese Pharmacy, Beijing University of Chinese Medicine, Chaoyang District Beijing</wicri:regionArea>
<wicri:noRegion>Chaoyang District Beijing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jian, Zaiyou" sort="Jian, Zaiyou" uniqKey="Jian Z" first="Zaiyou" last="Jian">Zaiyou Jian</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>School of Biological Science and Technology, Henan Institute of Science and Technology, Hualan Dao, Xinxiang City, Henan, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Biological Science and Technology, Henan Institute of Science and Technology, Hualan Dao, Xinxiang City, Henan</wicri:regionArea>
<wicri:noRegion>Henan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Zhongzhen" sort="Zhao, Zhongzhen" uniqKey="Zhao Z" first="Zhongzhen" last="Zhao">Zhongzhen Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eisenberg, David M" sort="Eisenberg, David M" uniqKey="Eisenberg D" first="David M." last="Eisenberg">David M. Eisenberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Osher Research Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clardy, Jon" sort="Clardy, Jon" uniqKey="Clardy J" first="Jon" last="Clardy">Jon Clardy</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23209822</idno>
<idno type="pmc">3507737</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507737</idno>
<idno type="RBID">PMC:3507737</idno>
<idno type="doi">10.1371/journal.pone.0050753</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000615</idno>
<idno type="wicri:Area/Pmc/Curation">000615</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000381</idno>
<idno type="wicri:Area/Ncbi/Merge">000374</idno>
<idno type="wicri:Area/Ncbi/Curation">000374</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Selection for High Oridonin Yield in the Chinese Medicinal Plant <italic>Isodon</italic>
(Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach</title>
<author><name sortKey="Harris, Eric S J" sort="Harris, Eric S J" uniqKey="Harris E" first="Eric S. J." last="Harris">Eric S. J. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Osher Research Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cao, Shugeng" sort="Cao, Shugeng" uniqKey="Cao S" first="Shugeng" last="Cao">Shugeng Cao</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Osher Research Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schoville, Sean D" sort="Schoville, Sean D" uniqKey="Schoville S" first="Sean D." last="Schoville">Sean D. Schoville</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Université Joseph Fourier Grenoble, Centre National de la Recherche Scientifique TIMC-IMAG UMR 5525, Equipe Biologie Computationnelle et Mathématique, Grenoble, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Joseph Fourier Grenoble, Centre National de la Recherche Scientifique TIMC-IMAG UMR 5525, Equipe Biologie Computationnelle et Mathématique, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dong, Chengming" sort="Dong, Chengming" uniqKey="Dong C" first="Chengming" last="Dong">Chengming Dong</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>College of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan</wicri:regionArea>
<wicri:noRegion>Henan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Wenquan" sort="Wang, Wenquan" uniqKey="Wang W" first="Wenquan" last="Wang">Wenquan Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>School of Chinese Pharmacy, Beijing University of Chinese Medicine, Chaoyang District Beijing, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Chinese Pharmacy, Beijing University of Chinese Medicine, Chaoyang District Beijing</wicri:regionArea>
<wicri:noRegion>Chaoyang District Beijing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jian, Zaiyou" sort="Jian, Zaiyou" uniqKey="Jian Z" first="Zaiyou" last="Jian">Zaiyou Jian</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>School of Biological Science and Technology, Henan Institute of Science and Technology, Hualan Dao, Xinxiang City, Henan, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Biological Science and Technology, Henan Institute of Science and Technology, Hualan Dao, Xinxiang City, Henan</wicri:regionArea>
<wicri:noRegion>Henan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Zhongzhen" sort="Zhao, Zhongzhen" uniqKey="Zhao Z" first="Zhongzhen" last="Zhao">Zhongzhen Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, PR China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eisenberg, David M" sort="Eisenberg, David M" uniqKey="Eisenberg D" first="David M." last="Eisenberg">David M. Eisenberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Osher Research Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clardy, Jon" sort="Clardy, Jon" uniqKey="Clardy J" first="Jon" last="Clardy">Jon Clardy</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Oridonin is a diterpenoid with anti-cancer activity that occurs in the Chinese medicinal plant <italic>Isodon rubescens</italic>
and some related species. While the bioactivity of oridonin has been well studied, the extent of natural variation in the production of this compound is poorly known. This study characterizes natural variation in oridonin production in order to guide selection of populations of <italic>Isodon</italic>
with highest oridonin yield. Different populations of <italic>I. rubescens</italic>
and related species were collected in China, and their offspring were grown in a greenhouse. Samples were examined for oridonin content, genotyped using 11 microsatellites, and representatives were sequenced for three phylogenetic markers (ITS, <italic>rps16, trnL-trnF</italic>
). Oridonin production was mapped on a molecular phylogeny of the genus <italic>Isodon</italic>
using samples from each population as well as previously published Genbank sequences. Oridonin has been reported in 12 out of 74 species of <italic>Isodon</italic>
examined for diterpenoids, and the phylogeny indicates that oridonin production has arisen at least three times in the genus. Oridonin production was surprisingly consistent between wild-collected parents and greenhouse-grown offspring, despite evidence of gene flow between oridonin-producing and non-producing populations of <italic>Isodon</italic>
. Additionally, microsatellite genetic distance between individuals was significantly correlated with chemical distance in both parents and offspring. Neither heritability nor correlation with genetic distance were significant when the comparison was restricted to only populations of <italic>I. rubescens</italic>
, but this result should be corroborated using additional samples. Based on these results, future screening of <italic>Isodon</italic>
populations for oridonin yield should initially prioritize a broad survey of all species known to produce oridonin, rather than focusing on multiple populations of one species, such as <italic>I. rubescens</italic>
. Of the samples examined here, <italic>I. rubescens</italic>
or <italic>I. japonicus</italic>
from Henan province would provide the best source of oridonin.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ikezoe, T" uniqKey="Ikezoe T">T Ikezoe</name>
</author>
<author><name sortKey="Chen, Ss" uniqKey="Chen S">SS Chen</name>
</author>
<author><name sortKey="Tong, Xj" uniqKey="Tong X">XJ Tong</name>
</author>
<author><name sortKey="Heber, D" uniqKey="Heber D">D Heber</name>
</author>
<author><name sortKey="Taguchi, H" uniqKey="Taguchi H">H Taguchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leung, Ch" uniqKey="Leung C">CH Leung</name>
</author>
<author><name sortKey="Grill, Sp" uniqKey="Grill S">SP Grill</name>
</author>
<author><name sortKey="Lam, W" uniqKey="Lam W">W Lam</name>
</author>
<author><name sortKey="Han, Qb" uniqKey="Han Q">QB Han</name>
</author>
<author><name sortKey="Sun, Hd" uniqKey="Sun H">HD Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bai, Ns" uniqKey="Bai N">NS Bai</name>
</author>
<author><name sortKey="He, K" uniqKey="He K">K He</name>
</author>
<author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name>
</author>
<author><name sortKey="Tsai, Ml" uniqKey="Tsai M">ML Tsai</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Cooper, M" uniqKey="Cooper M">M Cooper</name>
</author>
<author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name>
</author>
<author><name sortKey="Madhuri, Tk" uniqKey="Madhuri T">TK Madhuri</name>
</author>
<author><name sortKey="Wade, J" uniqKey="Wade J">J Wade</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cui, Q" uniqKey="Cui Q">Q Cui</name>
</author>
<author><name sortKey="Tashiro, Si" uniqKey="Tashiro S">SI Tashiro</name>
</author>
<author><name sortKey="Onodera, S" uniqKey="Onodera S">S Onodera</name>
</author>
<author><name sortKey="Minami, M" uniqKey="Minami M">M Minami</name>
</author>
<author><name sortKey="Ikejima, T" uniqKey="Ikejima T">T Ikejima</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, N" uniqKey="Kang N">N Kang</name>
</author>
<author><name sortKey="Zhang, Jh" uniqKey="Zhang J">JH Zhang</name>
</author>
<author><name sortKey="Qiu, F" uniqKey="Qiu F">F Qiu</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Tashiro, Si" uniqKey="Tashiro S">SI Tashiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, Gb" uniqKey="Zhou G">GB Zhou</name>
</author>
<author><name sortKey="Chen, Sj" uniqKey="Chen S">SJ Chen</name>
</author>
<author><name sortKey="Wang, Zy" uniqKey="Wang Z">ZY Wang</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Ye, Y" uniqKey="Ye Y">Y Ye</name>
</author>
<author><name sortKey="Chu, Jh" uniqKey="Chu J">JH Chu</name>
</author>
<author><name sortKey="Zhu, Gy" uniqKey="Zhu G">GY Zhu</name>
</author>
<author><name sortKey="Li, Yw" uniqKey="Li Y">YW Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meade Tollin, Lc" uniqKey="Meade Tollin L">LC Meade-Tollin</name>
</author>
<author><name sortKey="Wijeratne, Emk" uniqKey="Wijeratne E">EMK Wijeratne</name>
</author>
<author><name sortKey="Cooper, D" uniqKey="Cooper D">D Cooper</name>
</author>
<author><name sortKey="Guild, M" uniqKey="Guild M">M Guild</name>
</author>
<author><name sortKey="Jon, E" uniqKey="Jon E">E Jon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujita, E" uniqKey="Fujita E">E Fujita</name>
</author>
<author><name sortKey="Fujita, T" uniqKey="Fujita T">T Fujita</name>
</author>
<author><name sortKey="Katayama, H" uniqKey="Katayama H">H Katayama</name>
</author>
<author><name sortKey="Shibuya, M" uniqKey="Shibuya M">M Shibuya</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name>
</author>
<author><name sortKey="Chao, J" uniqKey="Chao J">J Chao</name>
</author>
<author><name sortKey="Lin, Z" uniqKey="Lin Z">Z Lin</name>
</author>
<author><name sortKey="Marunaka, T" uniqKey="Marunaka T">T Marunaka</name>
</author>
<author><name sortKey="Minami, Y" uniqKey="Minami Y">Y Minami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name>
</author>
<author><name sortKey="Halicka, Hd" uniqKey="Halicka H">HD Halicka</name>
</author>
<author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name>
</author>
<author><name sortKey="Traganos, F" uniqKey="Traganos F">F Traganos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ikezoe, T" uniqKey="Ikezoe T">T Ikezoe</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Bandobashi, K" uniqKey="Bandobashi K">K Bandobashi</name>
</author>
<author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name>
</author>
<author><name sortKey="Takemoto, S" uniqKey="Takemoto S">S Takemoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Am" uniqKey="Wong A">AM Wong</name>
</author>
<author><name sortKey="Zhang, Yj" uniqKey="Zhang Y">YJ Zhang</name>
</author>
<author><name sortKey="Kesler, K" uniqKey="Kesler K">K Kesler</name>
</author>
<author><name sortKey="Deng, M" uniqKey="Deng M">M Deng</name>
</author>
<author><name sortKey="Burhenn, L" uniqKey="Burhenn L">L Burhenn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Hd" uniqKey="Sun H">HD Sun</name>
</author>
<author><name sortKey="Huang, Sx" uniqKey="Huang S">SX Huang</name>
</author>
<author><name sortKey="Han, Qb" uniqKey="Han Q">QB Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Han, J" uniqKey="Han J">J Han</name>
</author>
<author><name sortKey="Ye, M" uniqKey="Ye M">M Ye</name>
</author>
<author><name sortKey="Chen, Hb" uniqKey="Chen H">HB Chen</name>
</author>
<author><name sortKey="Dai, Sj" uniqKey="Dai S">SJ Dai</name>
</author>
<author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Cy" uniqKey="Li C">CY Li</name>
</author>
<author><name sortKey="Wang, Eq" uniqKey="Wang E">EQ Wang</name>
</author>
<author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name>
</author>
<author><name sortKey="Bao, Jk" uniqKey="Bao J">JK Bao</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Eisenberg, Dm" uniqKey="Eisenberg D">DM Eisenberg</name>
</author>
<author><name sortKey="Harris, Esj" uniqKey="Harris E">ESJ Harris</name>
</author>
<author><name sortKey="Littlefield, Ba" uniqKey="Littlefield B">BA Littlefield</name>
</author>
<author><name sortKey="Cao, Sg" uniqKey="Cao S">SG Cao</name>
</author>
<author><name sortKey="Craycroft, Ja" uniqKey="Craycroft J">JA Craycroft</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Hw" uniqKey="Li H">HW Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zhong, Js" uniqKey="Zhong J">JS Zhong</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Conran, Jg" uniqKey="Conran J">JG Conran</name>
</author>
<author><name sortKey="Li, Hw" uniqKey="Li H">HW Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maki, M" uniqKey="Maki M">M Maki</name>
</author>
<author><name sortKey="Yamashiro, T" uniqKey="Yamashiro T">T Yamashiro</name>
</author>
<author><name sortKey="Dohzono, I" uniqKey="Dohzono I">I Dohzono</name>
</author>
<author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, Qb" uniqKey="Han Q">QB Han</name>
</author>
<author><name sortKey="Li, Ml" uniqKey="Li M">ML Li</name>
</author>
<author><name sortKey="Li, Sh" uniqKey="Li S">SH Li</name>
</author>
<author><name sortKey="Mou, Yk" uniqKey="Mou Y">YK Mou</name>
</author>
<author><name sortKey="Lin, Zw" uniqKey="Lin Z">ZW Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, Qb" uniqKey="Han Q">QB Han</name>
</author>
<author><name sortKey="Xiao, Wl" uniqKey="Xiao W">WL Xiao</name>
</author>
<author><name sortKey="Shen, Yh" uniqKey="Shen Y">YH Shen</name>
</author>
<author><name sortKey="Sun, Hd" uniqKey="Sun H">HD Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Oxelman, B" uniqKey="Oxelman B">B Oxelman</name>
</author>
<author><name sortKey="Liden, M" uniqKey="Liden M">M Liden</name>
</author>
<author><name sortKey="Berglund, D" uniqKey="Berglund D">D Berglund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taberlet, P" uniqKey="Taberlet P">P Taberlet</name>
</author>
<author><name sortKey="Gielly, L" uniqKey="Gielly L">L Gielly</name>
</author>
<author><name sortKey="Pautou, G" uniqKey="Pautou G">G Pautou</name>
</author>
<author><name sortKey="Bouvet, J" uniqKey="Bouvet J">J Bouvet</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clamp, M" uniqKey="Clamp M">M Clamp</name>
</author>
<author><name sortKey="Cuff, J" uniqKey="Cuff J">J Cuff</name>
</author>
<author><name sortKey="Searle, Sm" uniqKey="Searle S">SM Searle</name>
</author>
<author><name sortKey="Barton, Gj" uniqKey="Barton G">GJ Barton</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Farris, Js" uniqKey="Farris J">JS Farris</name>
</author>
<author><name sortKey="Kallersjo, M" uniqKey="Kallersjo M">M Kallersjo</name>
</author>
<author><name sortKey="Kluge, Ag" uniqKey="Kluge A">AG Kluge</name>
</author>
<author><name sortKey="Bult, C" uniqKey="Bult C">C Bult</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S Guindon</name>
</author>
<author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Posada, D" uniqKey="Posada D">D Posada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stamatakis, A" uniqKey="Stamatakis A">A Stamatakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Huelsenbeck, Jp" uniqKey="Huelsenbeck J">JP Huelsenbeck</name>
</author>
<author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F Ronquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F Ronquist</name>
</author>
<author><name sortKey="Huelsenbeck, Jp" uniqKey="Huelsenbeck J">JP Huelsenbeck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harris, Esj" uniqKey="Harris E">ESJ Harris</name>
</author>
<author><name sortKey="Klooster, Mr" uniqKey="Klooster M">MR Klooster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peakall, R" uniqKey="Peakall R">R Peakall</name>
</author>
<author><name sortKey="Smouse, Pe" uniqKey="Smouse P">PE Smouse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ritland, K" uniqKey="Ritland K">K Ritland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Cb" uniqKey="Chen C">CB Chen</name>
</author>
<author><name sortKey="Durand, E" uniqKey="Durand E">E Durand</name>
</author>
<author><name sortKey="Forbes, F" uniqKey="Forbes F">F Forbes</name>
</author>
<author><name sortKey="Francois, O" uniqKey="Francois O">O François</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Durand, E" uniqKey="Durand E">E Durand</name>
</author>
<author><name sortKey="Jay, F" uniqKey="Jay F">F Jay</name>
</author>
<author><name sortKey="Gaggiotti, Oe" uniqKey="Gaggiotti O">OE Gaggiotti</name>
</author>
<author><name sortKey="Francois, O" uniqKey="Francois O">O Francois</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Francois, O" uniqKey="Francois O">O François</name>
</author>
<author><name sortKey="Durand, E" uniqKey="Durand E">E Durand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jakobsson, M" uniqKey="Jakobsson M">M Jakobsson</name>
</author>
<author><name sortKey="Rosenberg, Na" uniqKey="Rosenberg N">NA Rosenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenberg, Na" uniqKey="Rosenberg N">NA Rosenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smouse, Pe" uniqKey="Smouse P">PE Smouse</name>
</author>
<author><name sortKey="Peakall, R" uniqKey="Peakall R">R Peakall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frantz, Ac" uniqKey="Frantz A">AC Frantz</name>
</author>
<author><name sortKey="Cellina, S" uniqKey="Cellina S">S Cellina</name>
</author>
<author><name sortKey="Krier, A" uniqKey="Krier A">A Krier</name>
</author>
<author><name sortKey="Schley, L" uniqKey="Schley L">L Schley</name>
</author>
<author><name sortKey="Burke, T" uniqKey="Burke T">T Burke</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000374 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000374 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= CyberinfraV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:3507737 |texte= Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:23209822" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a CyberinfraV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |