CyberinfraV1, Main, Exploration, bibRecord, 000720

A natural deletion of the HoxC cluster in elasmobranch fishes*

Identifieur interne : 000720 ( Main/Exploration ); précédent : 000719; suivant : 000721

A natural deletion of the HoxC cluster in elasmobranch fishes*

Auteurs : Benjamin L. King [États-Unis] ; J. Andrew Gillis [Royaume-Uni] ; Heather R. Carlisle [États-Unis] ; Randall D. Dahn [États-Unis]

Source :

Science (New York, N.y.) [ 0036-8075 ] ; 2011.

RBID : PMC:3264428

Abstract

Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of Hox genes into four paralogous clusters is a primitive feature of jawed vertebrates. Using high-throughput sequencing, we demonstrate the absence of all HoxC transcripts from embryos of the shark, Scyliorhinus canicula, and the skate, Leucoraja erinacea, and the absence of all HoxC genes and two HoxC-associated miRNAs from the genome of L. erinacea. These data suggest a loss of the entire HoxC cluster in elasmobranch fishes, and represent the evidence for natural deletion of an entire Hox cluster in vertebrates.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264428

DOI: 10.1126/science.1210912
PubMed: 22174244
PubMed Central: 3264428

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P2">Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of <italic>Hox</italic>
 genes into four paralogous clusters is a primitive feature of jawed vertebrates. Using high-throughput sequencing, we demonstrate the absence of all <italic>HoxC</italic>
 transcripts from embryos of the shark, <italic>Scyliorhinus canicula</italic>
, and the skate, <italic>Leucoraja erinacea</italic>
, and the absence of all <italic>HoxC</italic>
 genes and two <italic>HoxC</italic>
-associated miRNAs from the genome of <italic>L. erinacea</italic>
. These data suggest a loss of the entire <italic>HoxC</italic>
 cluster in elasmobranch fishes, and represent the evidence for natural deletion of an entire <italic>Hox</italic>
 cluster in vertebrates.</p>
</div>
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A natural deletion of the HoxC cluster in elasmobranch fishes*

A natural deletion of the HoxC cluster in elasmobranch fishes*

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Abstract

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